Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stefan Jaroch"'
Autor:
Markus Berger, Heike Schäcke, Hartmut Rehwinkel, Stefan Jaroch, Ekkehard May, Roland Neuhaus, Thomas M. Zollner, Antje Rottmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(16)
We report on the discovery of the new clinical candidate BAY 1003803 as glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis. In the course of optimizing the amino alcohol series as a highly potent new no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b9f1da763597d6cfc37a5c916d55e0
https://pubmed.ncbi.nlm.nih.gov/32631518
https://pubmed.ncbi.nlm.nih.gov/32631518
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug dis
Autor:
Lisa Wissler, Stefan Jaroch, Norbert Schmees, Andreas Reichel, Heike Schäcke, Hartmut Rehwinkel, Markus Berger, Karl Edman
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
We report on the discovery of two new lead series for the development of glucocorticoid receptor agonists. Firstly, the discovery of tetrahydronaphthalenes led to metabolically stable and dissociated compounds. Their binding mode to the glucocorticoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376ae470ffd5041091493be2417d76a
https://pubmed.ncbi.nlm.nih.gov/28043796
https://pubmed.ncbi.nlm.nih.gov/28043796
Publikováno v:
Handbook of experimental pharmacology. 232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db1de0690f0f61fd1a185a0d39d0c553
https://pubmed.ncbi.nlm.nih.gov/27222905
https://pubmed.ncbi.nlm.nih.gov/27222905
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783319289120
New Approaches to Drug Discovery
New Approaches to Drug Discovery
Preface.- Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis.- Part 3. Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f414de03e301e28ec0ff7e4140112f
https://doi.org/10.1007/978-3-319-28914-4
https://doi.org/10.1007/978-3-319-28914-4
Autor:
Larry E. Overman, Fay Ng, Sheldon Hiebert, Christopher J. Douglas, Robert Downham, Peter Chua, Neil K. Garg, Joy A. Middleton, Richard T. Matsuoka, Stefan Jaroch, Michael Becker
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 15
Author(s): Becker, Michael H; Chua, Peter; Downham, Robert; Douglas, Christopher J; Garg, Neil K; Hiebert, Sheldon; Jaroch, Stefan; Matsuoka, Richard T; Middleton, Joy A; Ng, Fay W; Overman, Larry E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08d1408c399b0cdcdac1a49d8c53cf5
https://doi.org/10.1021/jacs.8b03357
https://doi.org/10.1021/jacs.8b03357
Autor:
Stefan Jaroch, Yoshimitsu Nakano, Perenlei Enkhbaatar, Collette Jonkam, Matthias Lange, Lillian D. Traber, David N. Herndon, Daniel L. Traber, Jianpu Wang, Atsumori Hamahata
Publikováno v:
Shock. 32:253-257
Smoke inhalation injury is often complicated with pneumonia, which frequently leads to subsequent development of sepsis. Excessive NO has been shown to mediate many sepsis-related pathological responses. In the present study, we used our well-establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66b6ecde69f8d7c6465258aca61cf83
https://doi.org/10.1097/shk.0b013e318193e2ba
https://doi.org/10.1097/shk.0b013e318193e2ba
Autor:
Wolf-Dietrich Döcke, Hartmut Rehwinkel, Roland Neuhaus, Werner Skuballa, Khusru Asadullah, U Zügel, Ekkehard May, Stefan Jaroch, Heike Schäcke, Thomas M. Zollner
Publikováno v:
British Journal of Pharmacology. 158:1088-1103
Background and purpose: Glucocorticoids are highly effective in the therapy of inflammatory diseases. Their value, however, is limited by side effects. The discovery of the molecular mechanisms of the glucocorticoid receptor and the recognition that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee0adfb46870e725a8f594379137db1
https://doi.org/10.1111/j.1476-5381.2009.00238.x
https://doi.org/10.1111/j.1476-5381.2009.00238.x
Autor:
Joy A. Middleton, Robert Downham, Neil K. Garg, Sheldon Hiebert, Michael Becker, Peter Chua, Larry E. Overman, Fay W. Ng, Stefan Jaroch, Richard T. Matsuoka, Christopher J. Douglas
Publikováno v:
Journal of the American Chemical Society. 129:11987-12002
This article describes the details of our synthetic studies toward the complex marine alkaloid sarain A. Various strategies were conceived, setbacks encountered, and solutions developed, ultimately leading to a successful enantioselective total synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a308a40aa30119d8dd627fa35dc92d32
https://doi.org/10.1021/ja074300t
https://doi.org/10.1021/ja074300t
Autor:
Dave Davey, Karen May, Shou-Fu Lu, Ming Wei, Jih-Lie Tseng, Laura Dunning, Gary Phillips, Robert G. Wei, Bin Ye, Stefan Jaroch, James Onuffer, Binglong Chen, Babu Subramanyam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1883-1887
The guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde, 1, with an IC50 of 840 nM against the CCR5 receptor was identified using high-throughput screening. Optimization efforts led to the discovery of a novel piperidine series of CCR5 antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3d586f76f46efc9c15cd8d44fe75b6
https://doi.org/10.1016/j.bmcl.2007.01.050
https://doi.org/10.1016/j.bmcl.2007.01.050