Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stefan J Frohberger"'
Autor:
Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008427 (2020)
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic show
Externí odkaz:
https://doaj.org/article/82f0088c9fe348ba9d0ddb5af5d88a13
Autor:
Stefan J Frohberger, Frederic Fercoq, Anna-Lena Neumann, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Indulekha Karunakaran, Estelle Remion, Thomas Vogl, Achim Hoerauf, Coralie Martin, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0008119 (2020)
Neutrophils are essentially involved in protective immune responses against invading infective larvae of filarial nematodes. The present study investigated the impact of S100A8/S100A9 on protective immune responses against the rodent filarial nematod
Externí odkaz:
https://doaj.org/article/47a96f19ff3c4fe4acb52f8fb69ee0b4
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac
Autor:
Frédéric Fercoq, Estelle Remion, Stefan J Frohberger, Nathaly Vallarino-Lhermitte, Achim Hoerauf, John Le Quesne, Frédéric Landmann, Marc P Hübner, Leo M Carlin, Coralie Martin
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007691 (2019)
Lung disease is regularly reported in human filarial infections but the molecular pathogenesis of pulmonary filariasis is poorly understood. We used Litomosoides sigmodontis, a rodent filaria residing in the pleural cavity responsible for pleural inf
Externí odkaz:
https://doaj.org/article/2bfc6f2c66f34b1884638bed65d71050
Autor:
Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007636 (2019)
Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides s
Externí odkaz:
https://doaj.org/article/938a56b59b9342c292856f5bada424f0
Autor:
Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007159 (2019)
There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substanti
Externí odkaz:
https://doaj.org/article/68bed1add1a349b9b6bff6345f18be14
Autor:
Marc P Hübner, Alexandra Ehrens, Marianne Koschel, Bettina Dubben, Franziska Lenz, Stefan J Frohberger, Sabine Specht, Ludo Quirynen, Sophie Lachau-Durand, Fetene Tekle, Benny Baeten, Marc Engelen, Charles D Mackenzie, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0006320 (2019)
Flubendazole (FBZ) is highly efficacious against filarial nematodes after parenteral administration and presents a promising macrofilaricidal drug candidate for the elimination of onchocerciasis and other filariae. In the present study the efficacy o
Externí odkaz:
https://doaj.org/article/b3ac1e90612a4f61bf8699e5f26adb14
Autor:
Johanna F. Scheunemann, Frederic Risch, Julia J. Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J. Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Vaccines, Vol 11, Iss 5, p 966 (2023)
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated infective
Externí odkaz:
https://doaj.org/article/b87d9cd8fe334b3eaac4ac43de97300f
Autor:
Sabine Specht, Achim Harder, Steffen Hahnel, Ivan Scandale, Marc P. Hübner, Suzanne Gokool, Senyo Tagboto, Daniel Kulke, Achim Hoerauf, Simon Townson, Guilherme G. Verocai, Mary J. Maclean, Stefan J. Frohberger, Adrian J. Wolstenholme, Martin Glenschek-Sieberth
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 27-35 (2021)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 27-35 (2021)
Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori, and onchocerciasis (caused by Onchocerca volvulus) are neglected parasiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9429a47ac78d2ccda2d88d8a977303
http://europepmc.org/articles/PMC8347670
http://europepmc.org/articles/PMC8347670
Autor:
Johanna F. Scheunemann, Frederic Risch, Julia J. Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J. Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Infections with helminths affect more than one billion people worldwide. Despite an urgent need there is no vaccine available that would confer long lasting protection against helminth infections. Previous studies indicated that a vaccination with ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34a091f3e50ae8fcf36e42a8268c005f
https://doi.org/10.1101/2022.07.11.499516
https://doi.org/10.1101/2022.07.11.499516
