Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Stefan J Erkeland"'
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Autor:
Renée Beekman, Marijke Valkhof, Stefan J Erkeland, Erdogan Taskesen, Veronika Rockova, Justine K Peeters, Peter J M Valk, Bob Löwenberg, Ivo P Touw
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26537 (2011)
Acute myeloid leukemia (AML) results from multiple genetic and epigenetic aberrations, many of which remain unidentified. Frequent loss of large chromosomal regions marks haplo-insufficiency as one of the major mechanisms contributing to leukemogenes
Externí odkaz:
https://doaj.org/article/964aa76b293d4d1f93e7d2fe879265e4
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Jorn L. J. C. Assmann, Leticia G. Leon, Christiaan J. Stavast, Sanne E. van den Bogaerdt, Joyce Schilperoord-Vermeulen, Yorick Sandberg, Mar Bellido, Stefan J. Erkeland, David J. Feith, Thomas P. Loughran Jr, Anton W. Langerak
Publikováno v:
Leukemia, 36. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mut
Autor:
Stefan J. Erkeland
Publikováno v:
British Journal of Haematology. Wiley-Blackwell Publishing Ltd
Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that
Autor:
Ivo P. Touw, Bob Löwenberg, Ruud Delwel, Peter J.M. Valk, Roel G.W. Verhaak, Stefan J. Erkeland
Retroviral insertion mutagenesis is considered a powerful tool to identify cancer genes in mice, but its significance for human cancer has remained elusive. Moreover, it has recently been debated whether common virus integrations are always a hallmar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970f389de61d9838295fb12aaaa9f8b
https://doi.org/10.1158/0008-5472.c.6494151.v1
https://doi.org/10.1158/0008-5472.c.6494151.v1
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Autor:
Giada Dal Collo, Antoinette van Hoven-Beijen, Yu He, Yvonne M Muller, Yuandong Wang, Joe Zhao, Peter D Katsikis, Stefan J Erkeland
Publikováno v:
Blood, 140(Suppl 1). American Society of Hematology
INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) has proven to be effective for the treatment of hematopoietic disorders, including immune deficiencies, bone marrow failure syndromes (BMFS) and leukemia. However, current preparation for H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913ff0c93b84856ae58a1f127957ead7
https://pure.eur.nl/en/publications/3edcadd1-6c0f-4d39-afd6-4e9914295457
https://pure.eur.nl/en/publications/3edcadd1-6c0f-4d39-afd6-4e9914295457
Publikováno v:
Biomedicines. 10(6)
Small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modification of ribosomal RNAs, transfer RNAs and small nuclear RNAs, and thereby have important regulatory functions in mRNA splicing and protein translation. Several studies ha
Autor:
Vincent H.J. van der Velden, Kirsten van Lom, Stefan J. Erkeland, Joyce Schilperoord-Vermeulen, Harmen J.G. van de Werken, Eric M.J. Bindels, Anton W. Langerak, Antoinette van Hoven-Beijen, Giada Dal Collo, Mies C. Kappers-Klunne, Leticia G. Leon, Dick de Ridder, Yvonne M. Mueller, Christiaan J. Stavast, Iris van Zuijen
Publikováno v:
Haematologica 107 (2022) 1
Haematologica
Haematologica, 107(1), 143-153. Ferrata Storti Foundation
Haematologica, 107(1), 143-153
Haematologica
Haematologica, 107(1), 143-153. Ferrata Storti Foundation
Haematologica, 107(1), 143-153
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a49bf6663df046ef631dd27b68efa01