Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

Autor: Alfonso Urbanucci, Stefan J. Barfeld, Ville Kytölä, Harri M. Itkonen, Ilsa M. Coleman, Daniel Vodák, Liisa Sjöblom, Xia Sheng, Teemu Tolonen, Sarah Minner, Christoph Burdelski, Kati K. Kivinummi, Annika Kohvakka, Steven Kregel, Mandeep Takhar, Mohammed Alshalalfa, Elai Davicioni, Nicholas Erho, Paul Lloyd, R. Jeffrey Karnes, Ashley E. Ross, Edward M. Schaeffer, Donald J. Vander Griend, Stefan Knapp, Eva Corey, Felix Y. Feng, Peter S. Nelson, Fahri Saatcioglu, Karen E. Knudsen, Teuvo L.J. Tammela, Guido Sauter, Thorsten Schlomm, Matti Nykter, Tapio Visakorpi, Ian G. Mills

Publikováno v: Cell Reports, Vol 19, Iss 10, Pp 2045-2059 (2017)

Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been shown to associate with thes

Externí odkaz: https://doaj.org/article/a031c1acff234116bfd1c096aa18acae

Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells

Autor: Jens Preben Morth, Cinzia Progida, Hanne Guldsten, Ian G. Mills, Oddmund Bakke, Stefan J Barfeld, Magnus Ø. Arntzen, Harmonie Perdreau-Dahl, Bernd Thiede, Stefan Krauss

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Perdreau-Dahl, H, Progida, C, Barfeld, S J, Guldsten, H, Thiede, B, Arntzen, M, Bakke, O, Mills, I G, Krauss, S & Morth, J P 2020, ' Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells ', Communications Biology, vol. 3, no. 1, pp. 123 . https://doi.org/10.1038/s42003-020-0851-2
Communications Biology
Communications biology 3(1), 123 (2020). doi:10.1038/s42003-020-0851-2
'Communications Biology ', vol: 3, pages: 123-1-123-11 (2020)
Perdreau-Dahl, H, Progida, C, Barfeld, S J, Guldsten, H, Thiede, B, Arntzen, M, Bakke, O, Mills, I G, Krauss, S & Morth, J P 2020, ' Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells ', Communications Biology, vol. 3, no. 1, 123 . https://doi.org/10.1038/s42003-020-0851-2

Communications biology 3(1), 123 (2020). doi:10.1038/s42003-020-0851-2
Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) was first described as an auto-antigen over-expressed in Sjögren’s syndrome and in scleroderma patients. SSSCA1 has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f58a290bb80cb819b271b7ab8d27a72
http://link.springer.com/article/10.1038/s42003-020-0851-2

c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks

Autor: Srinivasan Yegnasubramanian, Alfonso Urbanucci, Bernd Thiede, Jessica L. Hicks, Ladan Fazli, Angelo M. DeMarzo, Harri M. Itkonen, Ian G. Mills, Stefan J Barfeld, Paul S. Rennie

Publikováno v: EBioMedicine
Barfeld, S J, Urbanucci, A, Itkonen, H M, Fazli, L, Hicks, J L, Thiede, B, Rennie, P S, Yegnasubramanian, S, DeMarzo, A M & Mills, I G 2017, ' c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks ', EBioMedicine, vol. 18, pp. 83-93 . https://doi.org/10.1016/j.ebiom.2017.04.006
EBioMedicine, Vol 18, Iss C, Pp 83-93 (2017)

Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de283a04e7f40f3ab01721f1c8f2c56
http://ora.ox.ac.uk/objects/uuid:

Mapping Protein-DNA Interactions Using ChIP-exo and Illumina-Based Sequencing

Autor: Stefan J, Barfeld, Ian G, Mills

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1443

Chromatin immunoprecipitation (ChIP) provides a means of enriching DNA associated with transcription factors, histone modifications, and indeed any other proteins for which suitably characterized antibodies are available. Over the years, sequence det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49f50c9a719c935a77247cadf11598dd
https://pubmed.ncbi.nlm.nih.gov/27246337

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

Autor: Yvonne Ceder, Andrei Chabes, Paul S. Rennie, Kirsi M. Kaukoniemi, Alfonso Urbanucci, Ian G. Mills, Lisette Marjavaara, Margareta Persson, Tapio Visakorpi, Ladan Fazli, Stefan J Barfeld

Publikováno v: Oncotarget; 6(14), pp 12587-12602 (2015)
Barfeld, S J, Fazli, L, Persson, M, Marjavaara, L, Urbanucci, A, Kaukoniemi, K M, Rennie, P S, Ceder, Y, Chabes, A, Visakorpi, T & Mills, I G 2015, ' Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer ', Oncotarget, vol. 6, no. 14, pp. 12587-602 . https://doi.org/10.18632/oncotarget.3494
Oncotarget

The androgen receptor is a key transcription factor contributing to the development of all stages of prostate cancer (PCa). In addition, other transcription factors have been associated with poor prognosis in PCa, amongst which c-Myc (MYC) is a well-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556bfb3b4e1211c14e5af8beb05e25fb
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101879