Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Stefan J, Erkeland"'
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Corina A. Ghebes, Jess Morhayim, Marion Kleijer, Merve Koroglu, Stefan J. Erkeland, Remco Hoogenboezem, Eric Bindels, Floris P. J. van Alphen, Maartje van den Biggelaar, Martijn A. Nolte, Bram C. J. van der Eerden, Eric Braakman, Carlijn Voermans, Jeroen van de Peppel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Recently, we and others have illustrated that extracellular vesicles (EVs) have the potential to support hematopoietic stem and progenitor cell (HSPC) expansion; however, the mechanism and processes responsible for the intercellular communication by
Externí odkaz:
https://doaj.org/article/f63912cbb2284cb18223a36ce8f0da38
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1229 (2022)
Small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modification of ribosomal RNAs, transfer RNAs and small nuclear RNAs, and thereby have important regulatory functions in mRNA splicing and protein translation. Several studies ha
Externí odkaz:
https://doaj.org/article/30ccc90d01a946d582dad4bcae94ad2d
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Publikováno v:
Cells, Vol 11, Iss 5, p 769 (2022)
Mounting data show that MIR139 is commonly silenced in solid cancer and hematological malignancies. MIR139 acts as a critical tumor suppressor by tuning the cellular response to different types of stress, including DNA damage, and by repressing oncog
Externí odkaz:
https://doaj.org/article/656cf7badba14b6b995aeee0a8a57c9d
Autor:
Stefan J. Erkeland
Publikováno v:
British Journal of Haematology. Wiley-Blackwell Publishing Ltd
Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcfa66f6c9a4c6a628c0b54e0c6a790
https://doi.org/10.1111/bjh.18780
https://doi.org/10.1111/bjh.18780
Autor:
Ivo P. Touw, Bob Löwenberg, Ruud Delwel, Peter J.M. Valk, Roel G.W. Verhaak, Stefan J. Erkeland
Retroviral insertion mutagenesis is considered a powerful tool to identify cancer genes in mice, but its significance for human cancer has remained elusive. Moreover, it has recently been debated whether common virus integrations are always a hallmar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970f389de61d9838295fb12aaaa9f8b
https://doi.org/10.1158/0008-5472.c.6494151.v1
https://doi.org/10.1158/0008-5472.c.6494151.v1
Autor:
Jorn L. J. C. Assmann, Leticia G. Leon, Christiaan J. Stavast, Sanne E. van den Bogaerdt, Joyce Schilperoord-Vermeulen, Yorick Sandberg, Mar Bellido, Stefan J. Erkeland, David J. Feith, Thomas P. Loughran Jr, Anton W. Langerak
Publikováno v:
Leukemia, 36. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbe792e0080c94f752304297c31470b
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f2bca13f38066d8dc8b044c3fbbe6
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
Autor:
Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importan
Externí odkaz:
https://doaj.org/article/045e79ae899f4457b4050ae3c4bfc370