Výsledky vyhledávání - "Stefan I, McDonough"

Akademický článek

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.

Autor: David J Matson, Darryl T Hamamoto, Howard Bregman, Melanie Cooke, Erin F DiMauro, Liyue Huang, Danielle Johnson, Xingwen Li, Jeff McDermott, Carrie Morgan, Ben Wilenkin, Annika B Malmberg, Stefan I McDonough, Donald A Simone

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138140 (2015)

While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological N

Externí odkaz: https://doaj.org/article/0837a210c9304876b8143a23aa472839

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Akademický článek

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Autor: Jacinthe Gingras, Sarah Smith, David J Matson, Danielle Johnson, Kim Nye, Lauren Couture, Elma Feric, Ruoyuan Yin, Bryan D Moyer, Matthew L Peterson, James B Rottman, Rudolph J Beiler, Annika B Malmberg, Stefan I McDonough

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e105895 (2014)

Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggest

Externí odkaz: https://doaj.org/article/49c66d94391141b6b07f7e6d7d29e53b

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Rare germline variants in individuals diagnosed with schizophrenia within multiplex families

Autor: Stefan I. McDonough, Lynn E DeLisi, Shangzhong Li

Publikováno v: Psychiatry research. 303

An extensive catalog of common and rare genetic variants contributes to overall risk for schizophrenia and related disorders. As a complement to population genetics efforts, here we present whole genome sequences of multiple affected probands within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af17430a1b817040caadc8472a2fc33b
https://pubmed.ncbi.nlm.nih.gov/34174581

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Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Autor: Shuyan Yi, Sonya G. Lehto, Stefan I. McDonough, Klaus Michelsen, Erin F. DiMauro, Hao Chen, Maosheng Zhang, Stephen Schneider, Shawn Ayube, Jason A. Luther, Matthew H. Plant, Xin Huang, David J. Matson, Jeffrey R. Simard, Howard Bregman, Jacinthe Gingras, Paul L. Shaffer, Yohannes Teffera

Publikováno v: Nature Structural & Molecular Biology. 24:108-113

Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective, central nervous system (CNS)-penetrant potentiators of glycine recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4d3f9eaf357c8330409b932db69a7e
https://doi.org/10.1038/nsmb.3329

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Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness

Autor: Robert W Sandrock, Oliver Homann, Edwin Lamas, Paul Nelson, Kira Misura, Lynn E. DeLisi, Stefan I. McDonough

Publikováno v: Molecular psychiatry

A current focus in psychiatric genetics is detection of multiple common risk alleles through very large genome-wide association study analyses. Yet families do exist, albeit rare, that have multiple affected members who are presumed to have a similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952e065a8640fff522af75024e1ea284
http://europepmc.org/articles/PMC5033653

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Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Autor: Joseph Ligutti, Les P. Miranda, Fen-Fen Lin, Shi-Yuan Meng, Anruo Zou, Stefan I. McDonough, Kaustav Biswas, Dong Liu, Kristin L. Andrews, Bryan D. Moyer, J. Ryan Holder, Justin K. Murray, Leszek Poppe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:4866-4871

Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel Na V 1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8eefd5b7362c35832a0347862bf39f
https://doi.org/10.1016/j.bmcl.2015.06.033

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Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Autor: Stefan I. McDonough, Joseph Ligutti, Hongyan Li, Reto Stöcklin, Les P. Miranda, Dong Liu, Justin K. Murray, Leszek Poppe, Philippe Favreau, Bryan D. Moyer, Kristin L. Andrews, Anruo Zou

Publikováno v: Journal of Medicinal Chemistry. 58:2299-2314

NaV1.7 is a voltage-gated sodium ion channel implicated by human genetic evidence as a therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula Grammostola porteri led to the identification of a 34-residue peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d924184b3ce6d78205b74b35e2df71df
https://doi.org/10.1021/jm501765v

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