Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Stefan Handtke"'
Autor:
Caroline Vayne, Raghavendra Palankar, Sandra Billy, Stefan Handtke, Thomas Thiele, Charlotte Cordonnier, Claire Pouplard, Andreas Greinacher, Yves Gruel, Jérôme Rollin
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
In order to improve the safety of COVID-19 vaccines, there is an urgent need to unravel the pathogenesis of vaccineinduced immune thrombotic thrombocytopenia (VITT), a severe complication of recombinant adenoviral vector vaccines used to prevent COVI
Externí odkaz:
https://doaj.org/article/9a0e205ed2294cf6a05bc0f0661eae37
Autor:
Stefan Handtke, Dirk Albrecht, Daniela Zühlke, Andreas Otto, Dörte Becher, Thomas Schweder, Kathrin Riedel, Michael Hecker, Birgit Voigt
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Background Bacillus pumilus cells exhibit a significantly higher resistance to hydrogen peroxide compared to closely related Bacilli like Bacillus subtilis. Results In this study we analyzed features of the catalase KatX2 of B. pumilus as on
Externí odkaz:
https://doaj.org/article/589fbc5fcfb94202ac6c22de22fea671
Autor:
Kristin Jahn, Stefan Handtke, Raghavendra Palankar, Thomas P. Kohler, Jan Wesche, Martina Wolff, Janina Bayer, Christiane Wolz, Andreas Greinacher, Sven Hammerschmidt
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:1464-1475
Toxins are key virulence determinants of pathogens and can impair the function of host immune cells, including platelets. Insights into pathogen toxin interference with platelets will be pivotal to improve treatment of patients with bacterial bloodst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9268c284a67adc596237d9e99c3e30fe
https://doi.org/10.1111/jth.15703
https://doi.org/10.1111/jth.15703
Autor:
Andreas Greinacher, Linda Schönborn, Florian Siegerist, Leif Steil, Raghavendra Palankar, Stefan Handtke, Alexander Reder, Thomas Thiele, Konstanze Aurich, Karen Methling, Michael Lalk, Uwe Völker, Nicole Endlich
Publikováno v:
Seminars in Hematology. 59:97-107
Vaccine-induced immune thrombotic thrombocytopenia (VITT; synonym, thrombosis with thrombocytopenia syndrome, is associated with high-titer immunoglobulin G antibodies directed against platelet factor 4 (PF4). These antibodies activate platelets via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4188e2936646775b96c1d346a305ab3
https://doi.org/10.1053/j.seminhematol.2022.02.004
https://doi.org/10.1053/j.seminhematol.2022.02.004
Autor:
Friederike Wiebe, Stefan Handtke, Jan Wesche, Annabel Schnarre, Raghavendra Palankar, Martina Wolff, Kristin Jahn, Franziska Voß, Sabrina Weißmüller, Jörg Schüttrumpf, Andreas Greinacher, Sven Hammerschmidt
Publikováno v:
Thrombosis and Haemostasis. 122:1147-1158
Platelets play an important role in the development and progression of respiratory distress. Functional platelets are known to seal inflammatory endothelial gaps and loss of platelet function has been shown to result in loss of integrity of pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0f4fb5093bff17086db35b1264c234
https://doi.org/10.1055/a-1723-1880
https://doi.org/10.1055/a-1723-1880
Autor:
Andreas Büttner, Michael Lalk, Raghavendra Palankar, Stefan Kochanek, Reiner K. Mailer, Evi X. Stavrou, Uwe Völker, Karen Methling, Thomas Renné, Konstanze Aurich, Leif Steil, Thomas Thiele, Lea Krutzke, Martin Beer, Maike Frye, Kathleen Selleng, Theodore E. Warkentin, Chandini Rangaswamy, Hanna Englert, Martina Wolff, Stephan Michalik, Linda Schönborn, Nicole Endlich, Florian Siegerist, Alexander Reder, Boris Fehse, Christian Hentschker, Jan Wesche, Stefan Handtke, Andreas Greinacher, Kati Franzke
Publikováno v:
Blood
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76a4e442ab525d6120a2decf8805622
https://doi.org/10.1182/blood.2021013231
https://doi.org/10.1182/blood.2021013231
Publikováno v:
Frontiers in Medicine, Vol 5 (2018)
Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations inclu
Externí odkaz:
https://doaj.org/article/225fa1c70006400ebddf878e6aec35da
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:818-820
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4835a5d3c03218cf25b8150de6c883
https://doi.org/10.1111/jth.15659
https://doi.org/10.1111/jth.15659
Autor:
Martina Wolff, Andreas Greinacher, N.-O. Hübner, Carlo Zaninetti, Jan Wesche, Stefan Handtke, Karsten Becker, Lena Ulm, Konstanze Aurich, Thomas Thiele, Linda Schönborn
Publikováno v:
Blood
Vaccination is crucial in combatting the severe acute respiratory syndrome coronavirus 2 pandemic. The rare complication of thrombocytopenia and thrombotic complications at unusual sites after ChAdOx1 nCov-19 vaccination is caused by platelet-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50180dad8e0b37a85ccec9e219a04f68
https://doi.org/10.1182/blood.2021012064
https://doi.org/10.1182/blood.2021012064
Autor:
Thomas Thiele, Stefan Handtke
Publikováno v:
Journal of Thrombosis and Haemostasis. 18:1256-1267
Platelets are most important in providing cellular hemostasis but also take part in inflammation and immune processes. Increased platelet size has been regarded as a feature describing a young and more reactive subpopulation until studies were publis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce68df9609c4da0d64f60d4049078d71
https://doi.org/10.1111/jth.14788
https://doi.org/10.1111/jth.14788