Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stefan H.E. Kaufmann"'
Autor:
Youchao Dai, Chuanzhi Zhu, Wei Xiao, Kaisong Huang, Xin Wang, Chenyan Shi, Dachuan Lin, Huihua Zhang, Xiaoqian Liu, Bin Peng, Yi Gao, Cui Hua Liu, Baoxue Ge, Stefan H.E. Kaufmann, Carl G. Feng, Xinchun Chen, Yi Cai
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor coactivator 4 (NCOA4) was recently identified as a cargo receptor in ferritin
Externí odkaz:
https://doaj.org/article/3478bdbf22844e8aa84990870d3c58ed
Autor:
Stefan H.E. Kaufmann
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 11, Pp 2660-2665 (2019)
Infectious diseases remain a major health threat, not only in resource-poor countries but also in pockets of poverty within middle-income and sometimes high-income countries. Whilst strong research and development for novel vaccines are urgently need
Externí odkaz:
https://doaj.org/article/b81947e588b640438351ac4620da2398
Autor:
Anh Thu Dang, Juliane Strietz, Alessandro Zenobi, Hanif J. Khameneh, Simon M. Brandl, Laura Lozza, Gregor Conradt, Stefan H.E. Kaufmann, Walter Reith, Ivo Kwee, Susana Minguet, Sonia T. Chelbi, Greta Guarda
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101900- (2021)
Summary: BTN3A molecules—BTN3A1 in particular—emerged as important mediators of Vγ9Vδ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular me
Externí odkaz:
https://doaj.org/article/de729f8b994f4debb0363e2537507785
Publikováno v:
Expert Review of Vaccines, Vol 16, Iss 8, Pp 845-853 (2017)
Introduction: The most recent estimates on tuberculosis (TB) morbidity and mortality reveal that the global disease burden is even higher than previously assumed. Better drugs, diagnostics and vaccines are major requirements to control the ongoing TB
Externí odkaz:
https://doaj.org/article/d2f3470329424f499a0d6811ec55baff
Autor:
January Weiner, Stefan H.E. Kaufmann
Publikováno v:
International Journal of Infectious Diseases, Vol 56, Iss C, Pp 258-262 (2017)
High-throughput techniques strive to identify new biomarkers that will be useful for the diagnosis, treatment, and prevention of tuberculosis (TB). However, their analysis and interpretation pose considerable challenges. Recent developments in the hi
Externí odkaz:
https://doaj.org/article/1f6a7f460665465297feede5cd454fd9
Publikováno v:
International Journal of Infectious Diseases, Vol 56, Iss C, Pp 263-267 (2017)
Tuberculosis (TB) remains the deadliest infectious disease. The widely used bacille Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine candidates for TB include subunit vaccines and inactivated whole-cell vaccines
Externí odkaz:
https://doaj.org/article/c451dcd1b39944de862062acf01e2428
Autor:
Gerald Voss, Danilo Casimiro, Olivier Neyrolles, Ann Williams, Stefan H.E. Kaufmann, Helen McShane, Mark Hatherill, Helen A Fletcher
Publikováno v:
F1000Research, Vol 7 (2018)
The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine mediated protection against TB is a possibility. A new TB vaccine is, therefore, an inevi
Externí odkaz:
https://doaj.org/article/723c537b85c9408fa2be6c69db3cb93e
Autor:
Bernd Eisele, Martin Gengenbacher, Reginald Kidd, David McCown, Sheldon Morris, Steven Derrick, David Hokey, Dominick Laddy, Rosemary Chang, Megan Fitzpatrick, Leander Grode, Kamalakannan Velmurugan, Stefan H.E. Kaufmann, John Fulkerson, Michael J. Brennan
Publikováno v:
Vaccines, Vol 1, Iss 2, Pp 120-138 (2013)
The failure of current Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating ne
Externí odkaz:
https://doaj.org/article/0faed53a9b714acc8f5dbb8a8015cef0
Autor:
Laura eLozza, Maura eFarinacci, Marina eBechtle, Manuela eStaeber, Ulrike eZedler, Andrea eBaiocchini, Franca edel Nonno, Stefan H.E. Kaufmann
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Human primary dendritic cells (DCs) are heterogeneous by phenotype, function and tissue localization and distinct from inflammatory monocyte-derived DCs. Current information regarding the susceptibility and functional role of primary human DC subsets
Externí odkaz:
https://doaj.org/article/a1d82b8372734cd5b95fb0c19add20b1
Autor:
Anca eDorhoi, Marco eIannaccone, Jeroen eMaertzdorf, Geraldine eNouailles, January eWeiner 3rd, Stefan H.E. Kaufmann
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Tuberculosis (TB) is a major health issue globally. Although typically the disease can be cured by chemotherapy and prevented – at least in part, in newborn by vaccination, general consensus exists that development of novel intervention measures re
Externí odkaz:
https://doaj.org/article/e7b7fae394f14e149c40e104b26daa03