Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium

Autor: Anita Aperia, Angus C. Nairn, Stefan H. Larsson, Paul Greengard, Natalya U. Fedosova, Ninel S. Logvinenko, Mikael Esmann, Irina Dulubova

Publikováno v: Aarhus University
Logvinenko, N S, Dulubova, I, Fedosova, N, Larsson, S H, Nairn, A C, Esmann, M, Greengard, P & Aperia, A 1996, ' Phosphorylation by protein kinase C of serine-23 of the alpha-1 subunit of rat Na+,K(+)-ATPase affects its conformational equilibrium ', Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 17, pp. 9132-9137 .

Phosphorylation of the alpha-1 subunit of rat Na+,K(+)-ATPase by protein kinase C has been shown previously to decrease the activity of the enzyme in vitro. We have now undertaken an investigation of the mechanism by which this inhibition occurs. Ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302bdbeca6288c72a6c1fbea20810af9
https://doi.org/10.1073/pnas.93.17.9132

Does the Wilms’ tumour suppressor gene, WT1, play roles in both splicing and transcription?

Autor: Jean-Paul Charlieu, Kiyoshi Miyagawa, Veronica van Heyningen, Nicholas D. Hastie, Stefan H Larsson

Publikováno v: Scopus-Elsevier

SUMMARY The Wilms’ tumour suppressor gene (WT1) encodes a protein(s) with 4 zinc fingers that is essential for the development of the genitourinary system. A considerable body of evidence exists to support the idea that WT1 binds DNA and functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ba9c3a3852522d1d4c2b7e47e9aae3
https://doi.org/10.1242/jcs.1995.supplement_19.14

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

Autor: Rachel Davies, Nicholas D. Hastie, Cinzia Calvio, Angus I. Lamond, Stefan H. Larsson, Eva Bratt

WT1 is essential for normal kidney development, and genetic alterations are associated with Wilms’ tumor, Denys Drash (DDS), and Frasier syndromes. Although generally considered a transcription factor this study has revealed that WT1 interacts with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7958876dfb27cd110661737f6912f8b
https://europepmc.org/articles/PMC317218/

Short-term primary cultures in studies of post-natal maturation of the rat proximal tubule-proton and bicarbonate transport

Autor: H. Ekblad, Stefan H. Larsson, Eva Bratt

Publikováno v: Pediatric nephrology (Berlin, Germany). 7(6)

This is a review of recent work based on an in vitro model which has allowed us to investigate the postnatal maturation of renal epithelial cells. Renal proximal tubule cells from 8- to 40-day-old Sprague-Dawley rats were studied after 48 h of primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27092909ee8889c047d66f4fd9f325cf
https://pubmed.ncbi.nlm.nih.gov/8130112

Intracellular pH regulation in cultured renal proximal tubule cells in different stages of maturation

Autor: H. Ekblad, Anita Aperia, Stefan H. Larsson

Publikováno v: The American journal of physiology. 263(4 Pt 2)

This study examines the ontogeny of cellular pH regulation in renal proximal tubule cells (RPTC). RPTC from 8- to 40-day-old Sprague-Dawley rats (RPTC-8 to RPTC-40) were studied after 48 h of primary culture. Intracellular pH (pHi) was measured by qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634a6ccad1f75e3d5822b04266a31895
https://pubmed.ncbi.nlm.nih.gov/1329559