Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Stefan H. Heinemann"'
Autor:
Philipp Rühl, Anagha G. Nair, Namrata Gawande, Sassrika N. C. W. Dehiwalage, Lukas Münster, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Most animal cell types are classified as non‐excitable because they do not generate action potentials observed in excitable cells, such as neurons and muscle cells. Thus, resolving voltage signals in non‐excitable cells demands sensors w
Externí odkaz:
https://doaj.org/article/855ab7dcc8a641398d50a0adff01d055
Autor:
Nirakar Sahoo, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has b
Externí odkaz:
https://doaj.org/article/845788ec9f91486e9f2c2f0cbd2a94fb
Autor:
Philipp Rühl, Johanna M. Langner, Jasmin Reidel, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Rühl et al. report the generation of ratiometric genetically encoded voltage indicators (GEVIs) and establish that they can be used in high-throughput automated imaging to measure compound membrane potential (Vm) in mammalian cells. This method is i
Externí odkaz:
https://doaj.org/article/d8fdccc7299e4650ba56c7bdfa3b227d
Autor:
Harald Prüss, Guido Gessner, Stefan H. Heinemann, Franz Rüschendorf, Ann-Kathrin Ruppert, Herbert Schulz, Thomas Sander, Wilhelm Rimpau
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, a
Externí odkaz:
https://doaj.org/article/3cefa7166a1c4a8eb67dbab21883cf8b
Autor:
Ajay Abisheck Paul George, Pascal Heimer, Enrico Leipold, Thomas Schmitz, Desiree Kaufmann, Daniel Tietze, Stefan H. Heinemann, Diana Imhof
Publikováno v:
Marine Drugs, Vol 17, Iss 7, p 390 (2019)
Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel NaV1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simulations bas
Externí odkaz:
https://doaj.org/article/32742123ecf1403585f3326f2a9638c7
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels
Autor:
Guido Gessner, Mahdi Jamili, Pascal Tomczyk, Dirk Menche, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Biol Chem
Heme (Fe2+-protoporphyrin IX) is a well-known protein prosthetic group; however, heme and hemin (Fe3+-protoporphyrin IX) are also increasingly viewed as signaling molecules. Among the signaling targets are numerous ion channels, with intracellular-fa
Autor:
Wiebke Pirschel, Antonio N. Mestekemper, Bianka Wissuwa, Nadine Krieg, Sarah Kröller, Christoph Daniel, Florian Gunzer, Emanuela Tolosano, Michael Bauer, Kerstin Amann, Stefan H. Heinemann, Sina M. Coldewey
Publikováno v:
Kidney International. 101:1171-1185
Thrombotic microangiopathy, hemolysis and acute kidney injury are typical clinical characteristics of hemolytic-uremic syndrome (HUS), which is predominantly caused by Shiga-toxin-producing Escherichia coli. Free heme aggravates organ damage in life-
Publikováno v:
Free radical biologymedicine. 192
Selenomethionine (SeMet) randomly replaces methionine (Met) in protein translation. Because of strongly differing redox properties of SeMet and Met, SeMet mis-incorporation may have detrimental effects on protein function, possibly compromising the u
Publikováno v:
ACS Chem Biol
Heme catabolism by heme oxygenase (HO) with a decrease in intracellular heme concentration and a concomitant local release of CO and Fe(2+) has potential to regulate BK(Ca) channels. Here we show that the iron-based photolabile CO-releasing molecule
Autor:
Alisa Bernert, Sandip M. Swain, Eric Wiesel, Nirakar Sahoo, Kefan Yang, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann, Ina Coburger
Publikováno v:
Pflugers Archiv
N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inact