Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Stefan H Oehlers"'
Autor:
Kathryn Wright, Kumudika de Silva, Karren M Plain, Auriol C Purdie, Tamika A Blair, Iain G Duggin, Warwick J Britton, Stefan H Oehlers
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009186 (2021)
Pathogenic mycobacteria actively dysregulate protective host immune signalling pathways during infection to drive the formation of permissive granuloma microenvironments. Dynamic regulation of host microRNA (miRNA) expression is a conserved feature o
Externí odkaz:
https://doaj.org/article/ab2479ec6bef4a43a7ab57ae13d447fa
Autor:
Pradeep Manuneedhi Cholan, Alvin Han, Brad R Woodie, Maxinne Watchon, Angela RM Kurz, Angela S Laird, Warwick J Britton, Lihua Ye, Zachary C Holmes, Jessica R McCann, Lawrence A David, John F Rawls, Stefan H Oehlers
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Short-chain fatty acids (SCFAs) are produced by microbial fermentation of dietary fiber in the gut. Butyrate is a particularly important SCFA with anti-inflammatory properties and is generally present at lower levels in inflammatory diseases associat
Externí odkaz:
https://doaj.org/article/2175f10d9d4f41ef94e9d5809bbe0133
BackgroundAccumulation of lipid in the liver is the first hallmark of both alcohol-related liver disease (ALD) and non-alcohol-related fatty liver disease (NAFLD). Recent studies indicate that specific mutations in lipid genes confer risk and might i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa292f856836ecd80968b2095cd3e77
https://doi.org/10.1101/2023.04.14.536511
https://doi.org/10.1101/2023.04.14.536511
Autor:
Kaiming Luo, Masahito Ogawa, Anita Ayer, Warwick J. Britton, Roland Stocker, Kazu Kikuchi, Stefan H. Oehlers
Publikováno v:
Zebrafish. 19:7-17
Autor:
Mark R. Cronan, Allison F. Rosenberg, Stefan H. Oehlers, Joseph W. Saelens, Dana M. Sisk, Kristen L. Jurcic Smith, Sunhee Lee, David M. Tobin
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1643-1650 (2015)
Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae have not yet developed a f
Externí odkaz:
https://doaj.org/article/fbc6a047ab644ff0bcd750ed2c5340d0
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Autor:
Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 817-829 (2015)
Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretio
Externí odkaz:
https://doaj.org/article/76a40966cdef441c9f341dd421b8e284
Autor:
Danielle C Garland, David M. Tobin, Julia Y Kam, Stefan H. Oehlers, Tina Cheng, Warwick J. Britton
Publikováno v:
Pathog Dis
Mycobacterial granuloma formation involves significant stromal remodeling including the growth of leaky, granuloma-associated vasculature. These permeable blood vessels aid mycobacterial growth, as antiangiogenic or vascular normalizing therapies are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98763789cee9bfd2fac2c4e24fd6226d
https://europepmc.org/articles/PMC9053305/
https://europepmc.org/articles/PMC9053305/
Autor:
Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers
Pathogenic mycobacteria inhibit inflammasome activation to establish infection. Although it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux, and inflammasome a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2d21d783a7bf9d3ed4aa37d022a788
https://hdl.handle.net/10453/158662
https://hdl.handle.net/10453/158662