Adverse outcome pathways: opportunities, limitations and open questions

Autor: Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung

Publikováno v: Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f557dd7872bdda32c94a20832dbd6
https://doi.org/10.1007/s00204-017-2045-3

Individual-based approaches to birth and death in avascu1ar tumors

Autor: Stefan Höhme, Dirk Drasdo

Publikováno v: Mathematical and Computer Modelling. 37:1163-1175

The understanding of the principles and the dominant mechanisms underlying tumor growth is an essential precondition in order to optimize treatment strategies. Mathematical and computer-based models can contribute to this since they allow testing of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd17b55a79602a8abf32629e13245e6
https://doi.org/10.1016/s0895-7177(03)00128-6

Stickstoff-Stoffwechsel während der Leber-Regeneration – Modellierung und Visualisierung

Autor: Rolf Gebhardt, Stefan Höhme, Reinhard Guthke, A. Bauer, S. Toepfer, Jan G. Hengstler, A. Krinner, M. Pfaff, J Böttger, F. Schließ, Dirk Drasdo, M. Brulport, Dieter Häussinger, Sebastian Zellmer

Publikováno v: Zeitschrift für Gastroenterologie. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc622eaed9e966261b911e51477634cb
https://doi.org/10.1055/s-0029-1191845

Mathematical modelling of liver regeneration after intoxication with CCl(4)

Autor: Alexander Bauer, Jan G. Hengstler, Rolf Gebhardt, Dirk Drasdo, Marc Brulport, Stefan Höhme, Marc Schäfer

Publikováno v: Chemico-biological interactions. 168(1)

Liver regeneration is a complex process, having evolved to protect animals from the consequences of liver loss caused by food toxins. In this study, we established a mathematical spatial-temporal model of the liver lobule regenerating after CCl(4) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29437607c9bb35b35fbef1edae448ff1
https://pubmed.ncbi.nlm.nih.gov/17442287