Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Stefan Höck"'
1
Akademický článek
CyBy2: a strongly typed, purely functional framework for chemical data management
Autor: Stefan Höck, Rainer Riedl
Publikováno v: Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract We present the development of CyBy 2 , a versatile framework for chemical data management written in purely functional style in Scala, a modern multi-paradigm programming language. Together with the core libraries we provide a fully function
Externí odkaz: https://doaj.org/article/a02e3a722bb940f1aeff3db7ed8bdbcc
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2
Akademický článek
CyBy2: A Structure-based Data Management Tool for Chemical and Biological Data
Autor: Stefan Höck, Rainer Riedl
Publikováno v: CHIMIA, Vol 66, Iss 3 (2012)
We report the development of a powerful data management tool for chemical and biological data: CyBy2. CyBy2 is a structure-based information management tool used to store and visualize structural data alongside additional information such as project
Externí odkaz: https://doaj.org/article/27a612c6944a4e97b2c3c283fc09e878
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3
Akademický článek
Thermal Cleavage of the Fmoc Protection Group
Autor: Stefan Höck, Roger Marti, Rainer Riedl, Marina Simeunovic
Publikováno v: CHIMIA, Vol 64, Iss 3 (2010)
The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented.
Externí odkaz: https://doaj.org/article/73a6c7ccb55a4a348a1d9fe66bfa689d
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4
Polysaccharide capsule composition of pneumococcal serotype 19A subtypes: Unaltered among subtypes and independent of the nutritional environment
Autor: Stefan Höck, Susanne Rüfenacht, Stephan Christen, Wolfgang Thormann, Markus Hilty, Lukas J. Troxler, Silvio D. Brugger, Kathrin Mühlemann, Julien Furrer, Brigitte Morand, Rudolf Geyer, Pascal M. Frey
Publikováno v: Infection and immunity
Brugger, Silvio; Troxler, Lukas; Rüfenacht, Susanne; Frey, Pascal Marcel; Morand, Brigitte; Geyer, Rudolf; Mühlemann, Kathrin; Höck, Stefan; Thormann, Wolfgang; Furrer, Julien; Christen, Stephan; Hilty, Markus (2016). Polysaccharide capsule composition of pneumococcal serotype 19A subtypes: Unaltered among subtypes and independent of the nutritional environment. Infection and immunity, 84(11), pp. 3152-3160. American Society for Microbiology 10.1128/IAI.00474-16
Serotype 19A strains have emerged as a cause of invasive pneumococcal disease after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), and serotype 19A has now been included in the recent 13-valent vaccine (PCV13). Genetic analys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e6b1b8fb914117a1b533492ebd1574
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5
High-Temperature Diels–Alder Reactions: Transfer from Batch to Continuous Mode
Autor: Stefan Höck, Stefan Abele, Jacques-Alexis Funel, Roger Marti, Gunther Schmidt
Publikováno v: Organic Process Research & Development. 16:1114-1120
The transfer of a Diels–Alder reaction of (cyclohexa-1,5-dien-1-yloxy)trimethylsilane 1 with α-acetoxyacrylonitrile 2 and acrylonitrile 8, respectively, from batch to continuous mode is presented, using standard and widely available laboratory equ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ade2af74897757797ccfb28fddd2515
https://doi.org/10.1021/op200320w
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6
Chirality transfer in an Ireland–Claisen rearrangement: a new approach toward the Iboga alkaloids
Autor: Hans-Jürg Borschberg, Stefan Höck, Florian M. Koch
Publikováno v: Tetrahedron: Asymmetry. 15:1801-1808
The synthesis of the isoquinuclidine core of the Iboga alkaloid family is described. This building block contains the entire stereochemical information of the targeted natural products. Starting with (S)-4-(hydroxymethyl)-4-butanolide, a derivative a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4e76c83c2f343dc12d0d82cf808503
https://doi.org/10.1016/j.tetasy.2004.04.028
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7
Enantioselective Synthesis of (−)-(19R)-Ibogamin-19-ol
Autor: Hans-Jürg Borschberg, Stefan Höck
The first total synthesis of the natural product (−)-(19R)-ibogamin-19-ol ((−)-1) is reported (biogenetic atom numbering). Starting with L-glutamic acid from the chiral pool and (2S)-but-3-en-2-ol, the crucial aliphatic isoquinuclidine (= 2-azabi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e152298b0b4cb5c627c7f6e6cf454d3
https://hdl.handle.net/11475/11999
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8
Enantioselective synthesis of key intermediates in a novel approach towards the Iboga-alkaloid family
Autor: Hans-Jürg Borschberg, Stefan Höck
Significant improvements in the realm of a recently disclosed, novel synthetic concept towards the Iboga alkaloid family are presented. The key step for the construction of the bicyclic aliphatic core consists of an intramolecular nitrone-olefin 1,3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa72833f70d8730c915bf93776f5c29
https://hdl.handle.net/11475/11997
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9
chemf: A purely functional chemistry toolkit
Autor: Stefan Höck, Rainer Riedl
Publikováno v: Journal of Cheminformatics
Background: Although programming in a type-safe and referentially transparent style offers several advantages over working with mutable data structures and side effects, this style of programming has not seen much use in chemistry-related software. S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b130b3984e22fb644f440b6fcbaa4ca
http://europepmc.org/articles/PMC3660204
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