Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Stefan H, Oehlers"'
Autor:
Julia Y. Kam, Elinor Hortle, Elizabeth Krogman, Sherridan E. Warner, Kathryn Wright, Kaiming Luo, Tina Cheng, Pradeep Manuneedhi Cholan, Kazu Kikuchi, James A. Triccas, Warwick J. Britton, Matt D. Johansen, Laurent Kremer, Stefan H. Oehlers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The pathogen Mycobacterium abscessus can switch from a smooth colony form (S) into a highly inflammatory, rough colony form (R) during infection. Here, Kam et al. use an adult zebrafish model of M. abscessus chronic infection to illustrate difference
Externí odkaz:
https://doaj.org/article/21538f5988d2474e8bf1b3bb89145259
Autor:
Hua Yang, Fei Wang, Xinya Guo, Feng Liu, Zhonghua Liu, Xiangyang Wu, Mengmeng Zhao, Mingtong Ma, Haipeng Liu, Lianhua Qin, Lin Wang, Tianqi Tang, Wei Sha, Yang Wang, Jianxia Chen, Xiaochen Huang, Jie Wang, Cheng Peng, Ruijuan Zheng, Fen Tang, Lu Zhang, Chunyan Wu, Stefan H. Oehlers, Zhigang Song, Jialei She, Hua Feng, Xunwei Xie, Baoxue Ge
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-18 (2021)
Abstract Pathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which the immune system contains, but fails to eliminate the mycobacteria. Fatty acid metabolism-related genes are relatively ov
Externí odkaz:
https://doaj.org/article/8926a826463b41a297a8323e451cdda6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Hyperglycaemia damages the microvasculature in part through the reduced recruitment of immune cells and interference with platelet signalling, leading to poor wound healing and accelerated lipid deposition in mammals. We investigated the uti
Externí odkaz:
https://doaj.org/article/2707e23cd20d44468938a193ff98e615
Autor:
Simone Morris, Kathryn Wright, Vamshikrishna Malyla, Warwick J. Britton, Philip M. Hansbro, Pradeep Manuneedhi Cholan, Stefan H. Oehlers
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 229-236 (2021)
Cigarette smoke (CS)-induced inflammation leads to a range of diseases including chronic obstructive pulmonary disease and cancer. The gut microbiota is a major modifying environmental factor that determine the severity of cigarette smoke-induced pat
Externí odkaz:
https://doaj.org/article/ac3940ada4fb4d368e7289d2319cf3b0
Autor:
Kathryn Wright, Kumudika de Silva, Karren M Plain, Auriol C Purdie, Tamika A Blair, Iain G Duggin, Warwick J Britton, Stefan H Oehlers
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009186 (2021)
Pathogenic mycobacteria actively dysregulate protective host immune signalling pathways during infection to drive the formation of permissive granuloma microenvironments. Dynamic regulation of host microRNA (miRNA) expression is a conserved feature o
Externí odkaz:
https://doaj.org/article/ab2479ec6bef4a43a7ab57ae13d447fa
Autor:
Pradeep Manuneedhi Cholan, Alvin Han, Brad R Woodie, Maxinne Watchon, Angela RM Kurz, Angela S Laird, Warwick J Britton, Lihua Ye, Zachary C Holmes, Jessica R McCann, Lawrence A David, John F Rawls, Stefan H Oehlers
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Short-chain fatty acids (SCFAs) are produced by microbial fermentation of dietary fiber in the gut. Butyrate is a particularly important SCFA with anti-inflammatory properties and is generally present at lower levels in inflammatory diseases associat
Externí odkaz:
https://doaj.org/article/2175f10d9d4f41ef94e9d5809bbe0133
BackgroundAccumulation of lipid in the liver is the first hallmark of both alcohol-related liver disease (ALD) and non-alcohol-related fatty liver disease (NAFLD). Recent studies indicate that specific mutations in lipid genes confer risk and might i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa292f856836ecd80968b2095cd3e77
https://doi.org/10.1101/2023.04.14.536511
https://doi.org/10.1101/2023.04.14.536511
Autor:
Kaiming Luo, Masahito Ogawa, Anita Ayer, Warwick J. Britton, Roland Stocker, Kazu Kikuchi, Stefan H. Oehlers
Publikováno v:
Zebrafish. 19:7-17
Autor:
Mark R. Cronan, Allison F. Rosenberg, Stefan H. Oehlers, Joseph W. Saelens, Dana M. Sisk, Kristen L. Jurcic Smith, Sunhee Lee, David M. Tobin
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1643-1650 (2015)
Visualization of infection and the associated host response has been challenging in adult vertebrates. Owing to their transparency, zebrafish larvae have been used to directly observe infection in vivo; however, such larvae have not yet developed a f
Externí odkaz:
https://doaj.org/article/fbc6a047ab644ff0bcd750ed2c5340d0
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s