Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stefan Grudzielanek"'
Autor:
Marianna Tatarek-Nossol, Stefan Grudzielanek, Anuj Shukla, Heinz Rehage, Aleksandra Velkova, Aphrodite Kapurniotu, Vytautas Smirnovas, Roland Winter
Publikováno v:
Journal of Molecular Biology. 370:372-384
Solvational perturbations were employed to selectively tune the aggregational preferences of insulin at 60 degrees C in vitro in purely aqueous acidic solution and in the presence of the model co-solvent ethanol (EtOH) (at 40%(w/w)). Dynamic light sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97def307b7682cafd98740eef3e83dfb
https://doi.org/10.1016/j.jmb.2007.04.053
https://doi.org/10.1016/j.jmb.2007.04.053
Publikováno v:
Advanced Synthesis & Catalysis
The first report of a fluorescence-based assay for the direct measurement of the regioselectivity of a reaction is described herein, developed from the desire to construct a quicker analytical method for the determination of the ratio of regioisomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871c153054e626aabaeaa33427f4f83e
https://doi.org/10.1002/adsc.200606047
https://doi.org/10.1002/adsc.200606047
Autor:
Roland Winter, Smirnovas, Stefan Grudzielanek, Revanur Ravindra, Nicolini C, Anna Loksztejn, Wojciech Dzwolak, Ralf Jansen, Sylwester Porowski
Publikováno v:
Biochemistry. 44:8948-8958
A model cosolvent, ethanol, has profound and diversified effects on the amyloidogenic self-assembly of insulin, yielding spectroscopically and morphologically distinguishable forms of beta-aggregates. The alcohol reduces hydrodynamic radii of insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecb8b77ef088e1cb0f7a19e4c210ecc
https://doi.org/10.1021/bi050281t
https://doi.org/10.1021/bi050281t
Publikováno v:
Chemistry and physics of lipids. 149(1-2)
In a simplified approach to the in vivo situation, where pathogenic fibrillar protein deposits are often found associated with cellular membranes, the aggregation kinetics of insulin in the presence of various model biomembranes were investigated usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bee1087ee6eca248e60799ad8cd3a2a
https://pubmed.ncbi.nlm.nih.gov/17603032
https://pubmed.ncbi.nlm.nih.gov/17603032
Publikováno v:
Journal of Non-Equilibrium Thermodynamics. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721fc14f0a5598ee76bb434df396ed5c
https://doi.org/10.1515/jnetdy.2007.003
https://doi.org/10.1515/jnetdy.2007.003
Publikováno v:
Journal of molecular biology. 356(2)
Solvation-assisted pressure tuning has been employed to unravel unknown structural and kinetic aspects of the insulin aggregation and fibrillation process. Our approach, using fluorescence, Fourier transform infrared and atomic force microscopy techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0809560f15a334fb72a502f164f75925
https://pubmed.ncbi.nlm.nih.gov/16376376
https://pubmed.ncbi.nlm.nih.gov/16376376