Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stefan Gerstenecker"'
Autor:
Valentin Wydra, Stefan Gerstenecker, Dieter Schollmeyer, Stanislav Andreev, Teodor Dimitrov, Ricardo Augusto Massarico Serafim, Stefan Laufer, Matthias Gehringer
Publikováno v:
Molbank, Vol 2021, Iss 1, p M1181 (2021)
Here we describe the synthesis of N-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic
Externí odkaz:
https://doaj.org/article/34bf14f260074d1bafe06b47476f421b
Autor:
Ricardo A. M. Serafim, André da Silva Santiago, Martin P. Schwalm, Zexi Hu, Caio V. dos Reis, Jessica E. Takarada, Priscila Mezzomo, Katlin B. Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan Laufer, Rafael M. Couñago, Matthias Gehringer
Publikováno v:
Journal of Medicinal Chemistry. 65:3173-3192
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint and clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative breast cancer. While long drug-target residence times have been sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f487f2c8d895ec56739c4e762882757
https://doi.org/10.1021/acs.jmedchem.1c01165
https://doi.org/10.1021/acs.jmedchem.1c01165
Autor:
Stefan Laufer, Mark Kudolo, Ricardo A. M. Serafim, Martin Schröder, Apirat Chaikuad, Valentin Wydra, Stefan Gerstenecker, Stefan Knapp, Martin P. Schwalm, Lisa Haarer, Matthias Gehringer
Publikováno v:
Cancers, Vol 13, Iss 5133, p 5133 (2021)
Cancers
Volume 13
Issue 20
Cancers
Volume 13
Issue 20
Simple Summary The two human p70 ribosomal S6 kinases, S6K1 and S6K2, have been associated with a variety of cellular processes and human pathologies, especially cancer. Thus far, only S6K1 was thoroughly studied and selectively addressed by small mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507eb9e9129a0d0c4760d1a96230fa96
https://www.mdpi.com/2072-6694/13/20/5133
https://www.mdpi.com/2072-6694/13/20/5133
Autor:
Katlin B. Massirer, Priscila Mezzomo, Mark Kudolo, A.S. Santiago, Apirat Chaikuad, Caio V. dos Reis, Matthias Gehringer, Rafael M. Couñago, Jessica Takarada, Ricardo A. M. Serafim, Stefan Knapp, Martin P. Schwalm, Stefan Laufer, Stefan Gerstenecker
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint securing proper chromosome segregation. It is being evaluated as a target in the treatment of aggressive tumors such as triple-negative breast cancer with several revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b037609509dc018037dcddecb4ee07df
https://doi.org/10.26434/chemrxiv.14601264
https://doi.org/10.26434/chemrxiv.14601264
Autor:
Ricardo A. M. Serafim, Matthias Gehringer, Stanislav Andreev, Teodor Dimitrov, Stefan Gerstenecker, Valentin Wydra, Dieter Schollmeyer, Stefan Laufer
Publikováno v:
Molbank, Vol 2021, Iss M1181, p M1181 (2021)
Here we describe the synthesis of N-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd9e42da8b481d208bc1647b157d315
https://www.mdpi.com/1422-8599/2021/1/M1181
https://www.mdpi.com/1422-8599/2021/1/M1181
Autor:
Chelsey Collins-Kautz, Gerhard Klebe, Stefan Gerstenecker, Björn Wagner, Andreas Heine, K. Ngo
Publikováno v:
Journal of medicinal chemistry. 63(6)
Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg. Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket. By cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab1f8e068c99b6ccbceeb6c09336fe7
https://pubmed.ncbi.nlm.nih.gov/32011145
https://pubmed.ncbi.nlm.nih.gov/32011145
Publikováno v:
International Journal of Molecular Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::c1337d2149f0a1113c60b6e843e0f217