Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stefan Ganscha"'
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-11 (2019)
Abstract We introduce TreeTop, an algorithm for single cell data analysis to identify and assign a branching score to branch points in biological processes which may have multi‐level branching hierarchies. We demonstrate branch point identification
Externí odkaz:
https://doaj.org/article/f8f29735831e421bbf04b6695c7d65a8
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005234 (2016)
Stochastic chemical reaction networks constitute a model class to quantitatively describe dynamics and cell-to-cell variability in biological systems. The topology of these networks typically is only partially characterized due to experimental limita
Externí odkaz:
https://doaj.org/article/3ea495a2a5f74e1bb3c82bbdabeade70
The reconstruction of gene regulatory networks from time resolved gene expression measurements is a key challenge in systems biology with applications in health and disease. While the most popular network inference methods are based on unsupervised l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1e29bc166270bce2bf3e64d9ed5ac2
https://doi.org/10.1101/356477
https://doi.org/10.1101/356477
We introduce TreeTop, an algorithm for single-cell data analysis to identify and assess statistical significance of branch points in biological processes with possibly multi-level branching hierarchies. We demonstrate branch point identification for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce29119f79726486ef6e89d2f643483
Autor:
Christian von Mering, Pascal Leuenberger, Paul J. Boersema, Valentina Cappelletti, Paola Picotti, Abdullah Kahraman, Stefan Ganscha, Manfred Claassen
Publikováno v:
Science (New York N.Y.)
How proteomes take the heat Living organisms are very sensitive to temperature, and much of this is attributed to its effect on the structure and function of proteins. Leuenberger et al. explored thermostability on a proteome-wide scale in bacteria,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f975e577ee22ea567bb3e6d984197f6
https://doi.org/10.1126/science.aai7825
https://doi.org/10.1126/science.aai7825
Autor:
Fabian J. Theis, Adam Filipczyk, Carsten Marr, Timm Schroeder, Stefan Ganscha, Simon Hastreiter, Michael Schwarzfischer, Manfred Claassen, Justin Feigelman
The autoregulatory motif of Nanog, a heterogeneously expressed core pluripotency factor in mouse embryonic stem cells, remains debated. Although recent time-lapse microscopy data provide the unparalleled ability to monitor Nanog expression at the sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e683ea6af7ca98a19275610ba6544e
Autor:
Simon Hastreiter, Adam Filipczyk, Manfred Claassen, Justin Feigelman, Michael Schwarzfischer, Carsten Marr, Fabian J. Theis, Stefan Ganscha, Timm Schroeder
Publikováno v:
Cell Syst. 3, 480-490 (2016)
SummaryMany cellular effectors of pluripotency are dynamically regulated. In principle, regulatory mechanisms can be inferred from single-cell observations of effector activity across time. However, rigorous inference techniques suitable for noisy, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d28e989da863ed7a969aa5b9d5b84d6