Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Stefan G. Sarafianos"'
Autor:
Dar-Yin Li, Matthew G. Donadu, Taylor Shue, Georgios Dangas, Antonis Athanasiadis, Shuiyun Lan, Xin Wen, Basem Battah, Stefania Zanetti, Vittorio Mazzarello, Stefan G. Sarafianos, Marco Ferrari, Eleftherios Michailidis
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1189 (2024)
Human coronaviruses are a continuous threat to the human population and have limited antiviral treatments, and the recent COVID-19 pandemic sparked interest in finding new antiviral strategies, such as natural products, to combat emerging coronavirus
Externí odkaz:
https://doaj.org/article/dc9924e25e554907a7b6b8305f4fe6af
Autor:
Anna T. Gres, Karen A. Kirby, William M. McFadden, Haijuan Du, Dandan Liu, Chaoyi Xu, Alexander J. Bryer, Juan R. Perilla, Jiong Shi, Christopher Aiken, Xiaofeng Fu, Peijun Zhang, Ashwanth C. Francis, Gregory B. Melikyan, Stefan G. Sarafianos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract HIV-1 capsid (CA) stability is important for viral replication. E45A and P38A mutations enhance and reduce core stability, thus impairing infectivity. Second-site mutations R132T and T216I rescue infectivity. Capsid lattice stability was stu
Externí odkaz:
https://doaj.org/article/6fc3ded6264445bc83e52d0bb630d90c
Autor:
Guangai Xue, Hyun Jae Yu, Cindy Buffone, Szu-Wei Huang, KyeongEun Lee, Shih Lin Goh, Anna T. Gres, Mehmet Hakan Guney, Stefan G. Sarafianos, Jeremy Luban, Felipe Diaz-Griffero, Vineet N. KewalRamani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The movement of viruses and other large macromolecular cargo through nuclear pore complexes (NPCs) is poorly understood. The human immunodeficiency virus type 1 (HIV-1) provides an attractive model to interrogate this process. HIV-1 capsid (
Externí odkaz:
https://doaj.org/article/b5c0d59bc5e54f7c8f940895d1b03f4a
Autor:
Maria E. Cilento, Xin Wen, Aaron B. Reeve, Obiaara B. Ukah, Alexa A. Snyder, Ciro M. Carrillo, Cole P. Smith, Kristin Edwards, Claudia C. Wahoski, Deborah R. Kitzler, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, Philip R. Tedbury, Stefan G. Sarafianos
Publikováno v:
Viruses, Vol 15, Iss 10, p 1990 (2023)
Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4′-ethynyl-2-fluoro-2′-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furt
Externí odkaz:
https://doaj.org/article/f8179306a49c4f7ea7367c95413a0d0c
Autor:
William M. McFadden, Alexa A. Snyder, Karen A. Kirby, Philip R. Tedbury, Monika Raj, Zhengqiang Wang, Stefan G. Sarafianos
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral genome and is an essential component of the infectious virus. In addition to its multiple roles throughout the viral life cycle, the capsid interacts with m
Externí odkaz:
https://doaj.org/article/643d8e60442642368bed50228dfd80e6
Autor:
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Jennifer A. Yoo, Xayathed Somoulay, Matthew A. Brown, Franck S. Mbuntcha Bogni, Vinay K. Pathak, Ferri Soheilian, Ryan L. Slack, Stefan G. Sarafianos, Wei-Shau Hu
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health. These recom
Externí odkaz:
https://doaj.org/article/86bec7df75394f38ab143fb2a046a35d
Autor:
Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 810-822 (2021)
Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replicati
Externí odkaz:
https://doaj.org/article/940cfa197a8a4055956585ef6fa096c7
Autor:
Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury, Stefan G. Sarafianos
Publikováno v:
Viruses, Vol 15, Iss 4, p 981 (2023)
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cyc
Externí odkaz:
https://doaj.org/article/4d194be6b0514626b0df621f63046235
Publikováno v:
Viruses, Vol 15, Iss 4, p 896 (2023)
Not many structures are common among all viruses: only nucleic acid and a protein coat [...]
Externí odkaz:
https://doaj.org/article/4587f177920a43b2b1ea3074126feadd
Autor:
Ashwanth C. Francis, Mariana Marin, Parmit K. Singh, Vasudevan Achuthan, Mathew J. Prellberg, Kristina Palermino-Rowland, Shuiyun Lan, Philip R. Tedbury, Stefan G. Sarafianos, Alan N. Engelman, Gregory B. Melikyan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially
Externí odkaz:
https://doaj.org/article/32dd990260c242f794d380d0f1625892