Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stefan G Krimmer"'
Autor:
Trung Hai Nguyen, Ariën S Rustenburg, Stefan G Krimmer, Hexi Zhang, John D Clark, Paul A Novick, Kim Branson, Vijay S Pande, John D Chodera, David D L Minh
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203224 (2018)
Isothermal titration calorimetry (ITC) is the only technique able to determine both the enthalpy and entropy of noncovalent association in a single experiment. The standard data analysis method based on nonlinear regression, however, provides unreali
Externí odkaz:
https://doaj.org/article/18f5005ec38b4fdb9b413060fb12dc72
Autor:
Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia, gastrointestinal stromal tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8553d50f41cd386bec88d09394d20e3c
https://doi.org/10.1073/pnas.2300054120
https://doi.org/10.1073/pnas.2300054120
Autor:
Sean P. Henry, Maria-Elena Liosi, Joseph A. Ippolito, Kara J. Cutrona, Stefan G. Krimmer, Ana S. Newton, Joseph Schlessinger, William L. Jorgensen
Publikováno v:
ACS Med Chem Lett
[Image: see text] The Janus kinase 2 (JAK2) pseudokinase domain (JH2) is an ATP-binding domain that regulates the activity of the catalytic tyrosine kinase domain (JH1). Dysregulation of JAK2 JH1 signaling caused by the V617F mutation in JH2 is impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a2477b4edebc570513fb94f2dc0c2c
https://doi.org/10.1021/acsmedchemlett.2c00051
https://doi.org/10.1021/acsmedchemlett.2c00051
Autor:
Stefan G. Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Sheng Shu, Sangwon Lee, Irit Lax, Wei Mi, Joseph Schlessinger
The receptor tyrosine kinase KIT and its ligand SCF are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia and mast cell leukemia, are driven by somatic ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b981cded905ea9dc717bb3d8d2127dbe
https://doi.org/10.1101/2022.09.08.506998
https://doi.org/10.1101/2022.09.08.506998
Autor:
Maria-Elena Liosi, Joseph A. Ippolito, Sean P. Henry, Stefan G. Krimmer, Ana S. Newton, Kara J. Cutrona, Rene A. Olivarez, Jyotidarsini Mohanty, Joseph Schlessinger, William L. Jorgensen
Publikováno v:
J Med Chem
JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of the activity of the kinase domain (JH1). V617F mutation in JH2 has been associated with the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd684b9cfa095978eecbe7070dc39fa
https://europepmc.org/articles/PMC9939005/
https://europepmc.org/articles/PMC9939005/
Publikováno v:
Journal of the American Chemical Society. 139(30)
We investigated the hydration state of the deep, well-accessible hydrophobic S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e11b8f87d928d8ee1dac524c2fd44971
https://pubmed.ncbi.nlm.nih.gov/28696673
https://pubmed.ncbi.nlm.nih.gov/28696673
Publikováno v:
ChemMedChem. 9:877-877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1ef4ab5b0549fd9449c4f1447a45ff
https://doi.org/10.1002/cmdc.201400087
https://doi.org/10.1002/cmdc.201400087