Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stefan F. Pinter"'
Autor:
Moritz Bauer, Enrique Vidal, Eduard Zorita, Nil Üresin, Stefan F. Pinter, Guillaume J. Filion, Bernhard Payer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Both A/B compartments and TADs are thought to be absent from the inactive X chromosome, but to be re-established with transcriptional reactivation and chromatin opening during X-reactivation. Here, the authors characterise gene reactivation, chromati
Externí odkaz:
https://doaj.org/article/d32434f601f34898a745cb1caef82c09
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest
Externí odkaz:
https://doaj.org/article/f77d839a60d344f6adff030162be5749
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Recent efforts in mapping spatial genome organization have revealed three evocative and conserved structural features of the inactive X in female mammals. First, the chromosomal conformation of the inactive X reveals a loss of topologically associate
Externí odkaz:
https://doaj.org/article/aa6e582c4cb1414a928735ce50c9e559
Autor:
Darcy T. Ahern, Prakhar Bansal, Isaac V. Faustino, Heather R. Glatt-Deeley, Yuvabharath Kondaveeti, Erin C. Banda, Stefan F. Pinter
Publikováno v:
bioRxiv
SUMMARYModeling the developmental etiology of viable human aneuploidies can be challenging in rodent models, where synteny with human chromosomes is affected, or primate-specific biology is implicated. In humans, monosomy-X (45,X) causes Turner syndr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6eb39f2faca93764e1857fc6ec2e17
https://doi.org/10.1101/2023.03.08.531747
https://doi.org/10.1101/2023.03.08.531747
Autor:
Darcy T. Ahern, Prakhar Bansal, Maria K. Armillei, Isaac V. Faustino, Yuvabharath Kondaveeti, Heather R. Glatt-Deeley, Erin C. Banda, Stefan F. Pinter
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the Y chromosome in males and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y pair dosage sensitivity, monosomy X is a leading cause of miscar
Autor:
Prakhar Bansal, Erin. C Banda, Heather R. Glatt-Deeley, Christopher E. Stoddard, Darcy T. Ahern, Yuvabharath Kondaveeti, Michael Nicouleau, Stefan F. Pinter
/SUMMARYExcess gene dosage from human chromosome 21 (HSA21), due to trisomy or translocation of HSA21 material, causes Down syndrome (DS). Trisomy 21 (T21) results in a large number of developmental and ongoing cellular phenotypes, raising the critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3691792e575afcb33eb0cb95f631cb1
https://doi.org/10.1101/2022.05.11.491519
https://doi.org/10.1101/2022.05.11.491519
Autor:
Darcy T. Ahern, Prakhar Bansal, Isaac Faustino, Yuvabharath Kondaveeti, Heather R. Glatt-Deeley, Erin C. Banda, Stefan F. Pinter
SUMMARY/ABSTRACTMammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the male Y and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y-pair dosage sensitivity, monosomy X is a leading cause of misca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2173dcbddc4b89598017766b17dec6c
https://doi.org/10.1101/2021.12.13.472325
https://doi.org/10.1101/2021.12.13.472325
Autor:
Stefan F Pinter
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2baab4000be4443db2cc0b8f99a9154d
https://doi.org/10.17504/protocols.io.bydvps66
https://doi.org/10.17504/protocols.io.bydvps66
Autor:
Eduard Zorita, Enrique Vidal, Nil Üresin, Bernhard Payer, Moritz Bauer, Stefan F. Pinter, Guillaume J. Filion
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
A hallmark of chromosome organization is the partition into transcriptionally active A and repressed B compartments, and into topologically associating domains (TADs). Both structures were regarded to be absent from the inactive mouse X chromosome, b
Contiguous erosion of the inactive X in human pluripotency concludes with global DNA hypomethylation
Publikováno v:
Cell reports
SUMMARY Female human pluripotent stem cells (hPSCs) routinely undergo inactive X (Xi) erosion. This progressive loss of key repressive features follows the loss of XIST expression, the long non-coding RNA driving X inactivation, and causes reactivati