Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stefan F H Neys"'
Publikováno v:
Cells, Vol 11, Iss 21, p 3391 (2022)
Aberrant B cell signaling plays a critical in role in various systemic and organ-specific autoimmune diseases. This is supported by genetic evidence by many functional studies in B cells from patients or specific animal models and by the observed eff
Externí odkaz:
https://doaj.org/article/7bd98d60ca34492584c509ef1087de45
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Bruton’s tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR). Targeting of BTK with small molecule inhibitors has proven to be e
Externí odkaz:
https://doaj.org/article/7147d38717af4d67b662d1b1c1d11485
Autor:
Peter Heukels, Jennifer A. C. van Hulst, Menno van Nimwegen, Carian E. Boorsma, Barbro N. Melgert, Jan H. von der Thusen, Bernt van den Blink, Rogier A. S. Hoek, Jelle R. Miedema, Stefan F. H. Neys, Odilia B. J. Corneth, Rudi W. Hendriks, Marlies S. Wijsenbeek, Mirjam Kool
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains un
Externí odkaz:
https://doaj.org/article/13715e292aad4ffcbe1f2d8589b1faa4
Autor:
Stefan F. H. Neys, Gwenny M. Verstappen, Hendrika Bootsma, Frans G. M. Kroese, Rudi W. Hendriks, Odilia B. J. Corneth
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5101 (2022)
Animal models of autoimmunity and human genetic association studies indicate that the dysregulation of B-cell receptor (BCR) signaling is an important driver of autoimmunity. We previously showed that in circulating B cells from primary Sjögren’s
Externí odkaz:
https://doaj.org/article/897ad00e58d048d6937ccdcc5668bdb9
Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis
Autor:
Stefan F. H. Neys, Peter Heukels, Jennifer A. C. van Hulst, Jasper Rip, Marlies S. Wijsenbeek, Rudi W. Hendriks, Odilia B. J. Corneth
Publikováno v:
Cells, Vol 10, Iss 6, p 1321 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease in which an impaired healing response to recurrent micro-injuries is thought to lead to fibrosis. Recent findings hint at a role for B cells and autoimmunity in IPF pathoge
Externí odkaz:
https://doaj.org/article/fa45eff5b9444030877a295a4126064e
Publikováno v:
Drugs, 81(14), 1605-1626. Adis
Drugs
Drugs
Systemic autoimmune disorders are complex heterogeneous chronic diseases involving many different immune cells. A significant proportion of patients respond poorly to therapy. In addition, the high burden of adverse effects caused by “classical”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ea1626e14e6222c1bb052f2a3690d8
https://doi.org/10.1007/s40265-021-01592-0
https://doi.org/10.1007/s40265-021-01592-0
Autor:
Marlies S. Wijsenbeek, Odilia B. J. Corneth, Menno van Nimwegen, Barbro N. Melgert, Carian E. Boorsma, Stefan F H Neys, Mirjam Kool, Jan H. von der Thüsen, Rogier A.S. Hoek, Bernt van den Blink, Jennifer A C van Hulst, Jelle R. Miedema, Peter Heukels, Rudi W. Hendriks
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019)
Respiratory Research
Respiratory Research, 20(1):232. BioMed Central Ltd.
Respiratory Research
Respiratory Research, 20(1):232. BioMed Central Ltd.
Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains unclear. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99b5f70c72f54b212d5e175859d105
http://link.springer.com/article/10.1186/s12931-019-1195-7
http://link.springer.com/article/10.1186/s12931-019-1195-7
Autor:
Simar Pal Singh, Jonas Willar, Jasper Rip, Stefan F H Neys, Marjolein J. W. de Bruijn, Jennifer A. C. Hulst, Rudi W. Hendriks, Odilia B. J. Corneth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df99a288b95c457fdcb7c47a1cf95a0
https://doi.org/10.1002/eji.202048968/v2/response1
https://doi.org/10.1002/eji.202048968/v2/response1
Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis
Autor:
Jennifer A C van Hulst, Jasper Rip, Odilia B. J. Corneth, Marlies S. Wijsenbeek, Peter Heukels, Rudi W. Hendriks, Stefan F H Neys
Publikováno v:
Cells
Volume 10
Issue 6
Cells, 10(6):1321. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 10, Iss 1321, p 1321 (2021)
Volume 10
Issue 6
Cells, 10(6):1321. Multidisciplinary Digital Publishing Institute (MDPI)
Cells, Vol 10, Iss 1321, p 1321 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease in which an impaired healing response to recurrent micro-injuries is thought to lead to fibrosis. Recent findings hint at a role for B cells and autoimmunity in IPF pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd0aac186eb71874085deeb626bbc33
https://pubmed.ncbi.nlm.nih.gov/34073225
https://pubmed.ncbi.nlm.nih.gov/34073225
Autor:
Rudi W. Hendriks, Marjolein J. W. de Bruijn, Simar Pal Singh, Odilia B. J. Corneth, Jennifer A C van Hulst, Jasper Rip, Stefan F H Neys, Jonas Willar
Publikováno v:
European Journal of Immunology, 51(9), 2251-2265. Wiley-VCH
Bruton's tyrosine kinase (Btk) is a crucial signaling molecule in B-cell receptor (BCR) signaling and a key regulator of B cell differentiation and function. Btk inhibition has shown impressive clinical efficacy in various B cell malignancies. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341cdb4bba6de0f3208c38fe45d0c4f4
https://pubmed.ncbi.nlm.nih.gov/34323286
https://pubmed.ncbi.nlm.nih.gov/34323286