Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stefan Eissler"'
Publikováno v:
Organic Process Research & Development. 26:1450-1457
Publikováno v:
Journal of Peptide Science. 23:757-762
In solid-phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important pro
Publikováno v:
Journal of Peptide Science
In solid‐phase peptide synthesis, the nominal batch size is calculated using the starting resin substitution and the mass of the starting resin. The starting resin substitution constitutes the basis for the calculation of a whole set of important p
Publikováno v:
Synlett. 2008:273-277
Unit A of cryptophycin 1 is a delta-hydroxy acid with four stereogenic centres. Our unit A synthesis introduces the first two stereogenic centres by a catalytic, asymmetric dihydroxylation, whereas the remaining two stereogenic centres are establishe
Publikováno v:
Synthesis. 2006:3747-3789
Nature provides a huge reservoir of highly diverse chemical compounds with interesting biological properties. Secondary metabolites continue to represent promising candidates for therapeutic applications and drugs are very often based on natural prod
Publikováno v:
Organic Letters. 9:817-819
[reaction: see text] Two short synthetic approaches toward cryptophycin unit A comprise a catalytic asymmetric dihydroxylation as the sole source of chirality, while all further stereogenic centers are introduced under substrate control. The key step
Publikováno v:
Organic letters. 12(5)
An endocyclic trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the triazole analogue was accomplished by macrolactamization as well as by Cu(I)-
Publikováno v:
ChemInform. 40
Many of today's most efficient anticancer chemotherapeutics interfere with microtubule dynamics. They prevent microtubules from forming correct mitotic spindles, therefore cause an arrest of the cell-division cycle and eventually trigger programmed c
Cryptophycins are a family of highly cytotoxic, cyclic depsipeptides. They display antitumour activity that is largely maintained for multidrug-resistant tumour cells. Cryptophycins are composed of four building blocks (units A-D) that correspond to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e8c4b7da64edd6b053b9a78f562cf2
https://doi.org/10.1002/chem.200901750
https://doi.org/10.1002/chem.200901750
Publikováno v:
Organic Letters; Mar2007, Vol. 9 Issue 5, p817-819, 3p