Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Stefan E.H. Alexson"'
Autor:
Kristen L. King, Martin E. Young, Janos Kerner, Hazel Huang, Karen M. O'Shea, Stefan E.H. Alexson, Charles L. Hoppel, William C. Stanley
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1511-1517 (2007)
Peroxisome proliferator-activated receptor α (PPARα) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling protein 3 (UCP3), which are induced in the heart at the mRNA level in response to diabetes.
Externí odkaz:
https://doaj.org/article/7f9c757c21214778a1ae087133aa4bc3
Autor:
Mary C. Hunt, Junji Yamada, Lois J. Maltais, Mathew W. Wright, Ernesto J. Podesta, Stefan E.H. Alexson
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 9, Pp 2029-2032 (2005)
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid
Externí odkaz:
https://doaj.org/article/3f1ae3b02bec4246a0967c10fc30eff5
Autor:
Karianne Solaas, B. Frode Kase, Viet Pham, Krister Bamberg, Mary C. Hunt, Stefan E.H. Alexson
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 6, Pp 1051-1060 (2004)
In human liver, unconjugated bile acids can be formed by the action of bile acid-CoA thioesterases (BACTEs), whereas bile acid conjugation with taurine or glycine (amidation) is catalyzed by bile acid-CoA:amino acid N-acyltransferases (BACATs). Both
Externí odkaz:
https://doaj.org/article/ee9730ab01f54a58be993c30a9dd3e52
Autor:
Margareta A. Diczfalusy, Ingemar Björkhem, Curt Einarsson, Carl-Gustaf Hillebrant, Stefan E.H. Alexson
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 7, Pp 1025-1032 (2001)
Elevated fatty acid ethyl ester (FAEE) concentrations have been detected in postmortem organs from alcoholics and patients acutely intoxicated by alcohol, and FAEE have been implicated as mediators of ethanol-induced organ damage. The formation of FA
Externí odkaz:
https://doaj.org/article/3d2f1ddf98684ac08c4e68502782e92d
Autor:
Mary C. Hunt, Per J.G. Lindquist, Jeffrey M. Peters, Frank J. Gonzalez, Ulf Diczfalusy, Stefan E.H. Alexson
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 814-823 (2000)
Long-chain acyl-CoA thioesterases catalyze the hydrolysis of acyl-CoAs to the corresponding free fatty acid and CoA. We recently cloned four members of a novel multigene family of peroxisome proliferator-induced genes encoding cytosolic (CTE-I), mito
Externí odkaz:
https://doaj.org/article/a28da9531d8844a495d928be33cff36a
Publikováno v:
Trends in Endocrinology & Metabolism. 28:473-484
The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A (CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into complex lipids. Acyl-CoA thioesterases constitute a family of enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185af26dad4e1398ad41dc1789f49650
https://doi.org/10.1016/j.tem.2017.03.001
https://doi.org/10.1016/j.tem.2017.03.001
Autor:
Ulrich Bergmann, Patrick Moreau, Rajesh K. Harijan, Frédéric Bringaud, Paul A.M. Michels, Muriel Mazet, Rik K. Wierenga, Tiila R. Kiema, Guillaume Bouyssou, Stefan E.H. Alexson
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:1075-1096
Bioinformatics studies have shown that the genomes of trypanosomatid species each encode one SCP2-thiolase-like protein (SLP), which is characterized by having the YDCF thiolase sequence fingerprint of the Cβ2-Cα2 loop. SLPs are only encoded by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32dd5bcca2fcc4f20e835910c1abd86a
https://doi.org/10.1002/prot.25054
https://doi.org/10.1002/prot.25054
Autor:
Björn Rozell, Chiara Pavanello, Veronika Tillander, Raoul Kuiper, Lena Burri, Jon Skorve, Rolf K. Berge, Matteo Pedrelli, Bodil Bjørndal, Marta Turri, Thomas Lundåsen, Stefan E.H. Alexson
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229322 (2020)
PLOS ONE
e0229322
PLoS ONE
PLOS ONE
e0229322
PLoS ONE
Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including activation of peroxisome p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cf346941d73fd636ac8e66555a453c
https://doi.org/10.1371/journal.pone.0229322
https://doi.org/10.1371/journal.pone.0229322
Autor:
Rita Vik, Kim Ekroos, Veronika Tillander, Rolf K. Berge, Terhi Vihervaara, Stefan E.H. Alexson, Bodil Bjørndal, Jon Skorve
Publikováno v:
Food Chemistry. 183:101-110
This study investigates the effects of salmon peptide fractions, generated using different enzymatic hydrolyzation methods, on hepatic lipid metabolism. Four groups of mice were fed a high-fat diet with 20% casein (control group) or 15% casein and 5%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dc2ced13f86edb4b0ab140732a206
Autor:
Toshiyuki Fukao, Rajesh K. Harijan, Malgorzata Strozyk, Rik K. Wierenga, Tiila Riikka Kiema, Stefan E.H. Alexson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:3212-3225
Crystal structures of human mitochondrial 3-ketoacyl-CoA thiolase (hT1) in the apo form and in complex with CoA have been determined at 2.0 Å resolution. The structures confirm the tetrameric quaternary structure of this degradative thiolase. The ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f5498fe30d8790cbd4d6e90c9b6a54
https://doi.org/10.1107/s1399004714023827
https://doi.org/10.1107/s1399004714023827