Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Stefan D. Knight"'
Autor:
Femke Beiroth, Tomas Koudelka, Thorsten Overath, Stefan D. Knight, Andreas Tholey, Thisbe K. Lindhorst
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1890-1900 (2018)
Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, cru
Externí odkaz:
https://doaj.org/article/b8edb137bf5e4efea7550a8f90888308
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 810-822 (2010)
Mannose-specific adhesion of Escherichia coli bacteria to cell surfaces, the cause of various infections, is mediated by a fimbrial lectin, called FimH. X-ray studies have revealed a carbohydrate recognition domain (CRD) on FimH that can complex α-D
Externí odkaz:
https://doaj.org/article/2a80bfb54ff2403080a2547d1d06c86f
Autor:
Tobias Dahlberg, Magnus Andersson, N. A. Pakharukova, Grant J. Jensen, Minna Tuittila, Si Lhyam Myint, Bernt Eric Uhlin, Yi-Wei Chang, Urpo Lamminmäki, Stefan D. Knight, Sari Paavilainen, Anton V. Zavialov, Henri Malmi, Debnath Ghosal
Adhesive pili are hair-like appendages assembled via the chaperone-usher pathway (CUP) that mediate host tissue colonization and biofilm formation of Gram-negative bacteria 1-3. Archaic CUP pili, the most diverse and widespread CUP adhesins, are prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c8d6b2e4812930632f10b82791fc6a
https://doi.org/10.21203/rs.3.rs-936177/v1
https://doi.org/10.21203/rs.3.rs-936177/v1
Publikováno v:
Acta Crystallographica Section D Structural Biology. 75:618-627
Spider silk is a biomaterial with exceptional mechanical toughness, and there is great interest in developing biomimetic methods to produce engineered spider silk-based materials. However, the mechanisms that regulate the conversion of spider silk pr
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:1053-1062
The important uropathogenProteus mirabilisencodes a record number of chaperone/usher-pathway adhesive fimbriae. Such fimbriae, which are used for adhesion to cell surfaces/tissues and for biofilm formation, are typically important virulence factors i
Autor:
Allison N. Norsworthy, Wimal Ubhayasekera, Melanie M. Pearson, Nina Serr, Harry L. T. Mobley, Stefan D. Knight, Michael C. Breed, Wangshu Jiang
Publikováno v:
'PLoS Pathogens ', vol: 16, pages: e1008707-1-e1008707-38 (2020)
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 8, p e1008707 (2020)
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 8, p e1008707 (2020)
Proteus mirabilis, a Gram-negative uropathogen, is a major causative agent in catheter-associated urinary tract infections (CAUTI). Mannose-resistant Proteus-like fimbriae (MR/P) are crucially important for P. mirabilis infectivity and are required f
Autor:
Natalia, Pakharukova, Minna, Tuittila, Sari, Paavilainen, Henri, Malmi, Olena, Parilova, Susann, Teneberg, Stefan D, Knight, Anton V, Zavialov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(21)
Publikováno v:
Biochemistry. 52:7523-7531
Amyloid diseases are defined by tissue deposition of insoluble, fibrillar beta-sheet polymers of specific proteins, but it appears that toxic oligomeric species rather than the fibrils are the main cause of tissue degeneration. Many proteins can form
Autor:
Stefan D. Knight, Anton V. Zavialov, Sheila MacIntyre, Xiaodi Yu, Anatoly Dubnovitsky, Alex F. Pudney
Publikováno v:
Structure. 20(11):1861-1871
Summary Many virulence organelles of Gram-negative bacterial pathogens are assembled via the chaperone/usher pathway. The chaperone transports organelle subunits across the periplasm to the outer membrane usher, where they are released and incorporat
Publikováno v:
Microbiology (Reading, England). 162(4)
A Myxococcus xanthus gene, MXAN3487, was identified by transposon mutagenesis to be required for the expression of mcuABC, an operon coding for part of the chaperone–usher (CU) system in this bacterium. The MXAN3487 protein displays sequence and st