Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Stefan Düsterhöft"'
Autor:
Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL). We noted that a disintegrin and metalloproteinase (ADAM) 10 and AD
Externí odkaz:
https://doaj.org/article/75cc414e38db4c68b7887fc90fb16ffa
Autor:
Silvia Detro-Dassen, Anna Sternberg, Sonja Maria Lehmann, Katharina Schwandt, Stefan Düsterhöft, Walter Becker
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-4 (2024)
Abstract Background Two new missense variants (K68Q and R252H) of the protein kinase DYRK1B were recently reported to cause a monogenetic form of metabolic syndrome with autosomal dominant inheritance (AOMS3). Results Our in vitro functional analysis
Externí odkaz:
https://doaj.org/article/d5f16cd29b764a5f864270908a86ca21
Autor:
Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Gross, Pavel Strnad, Stefan Düsterhöft, Andreas Ludwig
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The metalloproteinase ADAM17 contributes to inflammatory and proliferative responses by shedding of cell-surface molecules. By this ADAM17 is implicated in inflammation, regeneration, and permeability regulation of epithelial cells in the co
Externí odkaz:
https://doaj.org/article/c7d103e642b14b5ca8e1c1bf8369154f
Autor:
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor
Externí odkaz:
https://doaj.org/article/5fcbad4a86ec408db5a8eceac4164627
Autor:
Aaron Babendreyer, Diana M. Rojas-González, Anja Adelina Giese, Sandra Fellendorf, Stefan Düsterhöft, Petra Mela, Andreas Ludwig
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Background: Endothelial function significantly depends on the proteolytic release of surface expressed signal molecules, their receptors and adhesion molecules via the metalloproteinase ADAM17. The pseudoproteases iRhom1 and 2 independently function
Externí odkaz:
https://doaj.org/article/85baebc2f6064f8a8b8605b7ce08238c
Autor:
Marianne Zaruba, Hann-Wei Chen, Ole Frithjof Pietsch, Kati Szakmary-Braendle, Angelika Auer, Marlene Mötz, Kerstin Seitz, Stefan Düsterhöft, Aspen M. Workman, Till Rümenapf, Christiane Riedel
Publikováno v:
Viruses, Vol 14, Iss 2, p 381 (2022)
The entry of BVDV into bovine cells was studied using CRIB cells (cells resistant to infection with bovine viral diarrhea virus [BVDV]) that have evolved from MDBK cells by a spontaneous loss of susceptibility to BVDV. Recently, larger genetic deleti
Externí odkaz:
https://doaj.org/article/458e964a836b468a8098c0b73694a755
Autor:
Christopher Platen, Stephan Dreschers, Jessica Wappler, Andreas Ludwig, Stefan Düsterhöft, Lucy Kathleen Reiss, Thorsten W. Orlikowsky
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the i
Externí odkaz:
https://doaj.org/article/6a42732b3fa249fda8395aa22f34e8ee
Autor:
Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi, Karina Reiss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase
Externí odkaz:
https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f
Autor:
Anke Seifert, Justyna Wozniak, Stefan Düsterhöft, Petr Kasparek, Radislav Sedlacek, Stephan Dreschers, Thorsten W. Orlikowsky, Daniela Yildiz, Andreas Ludwig
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 5978 (2020)
Uptake of bacteria by phagocytes is a crucial step in innate immune defence. Members of the disintegrin and metalloproteinase (ADAM) family critically control the immune response by limited proteolysis of surface expressed mediator molecules. Here, w
Externí odkaz:
https://doaj.org/article/96067ddf0b0344a9bad264ed6bbff2bc
Autor:
Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Publikováno v:
PLoS Biology, Vol 15, Iss 1, p e2000080 (2017)
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely
Externí odkaz:
https://doaj.org/article/0de46d7cf5e847c6bf5e71b31996514a