Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Stefan DÜBEL"'
Autor:
Stefan Dübel
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
There is no doubt that today’s life sciences would look very different without the availability of millions of research antibody products. Nevertheless, the use of antibody reagents that are poorly characterized has led to the publication of false
Externí odkaz:
https://doaj.org/article/86f5d6d3461e48e79af986cb8b1ea094
Autor:
Maximilian Ruschig, Jana Nerlich, Marlies Becker, Doris Meier, Saskia Polten, Karla Cervantes-Luevano, Philipp Kuhn, Alexei Fedorovish Licea-Navarro, Stefan Hallermann, Stefan Dübel, Maren Schubert, Jeffrey Brown, Michael Hust
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Poisoning by widow-spider (genus Latrodectus) bites occurs worldwide. The illness, termed latrodectism, can cause severe and persistent pain and can lead to muscle rigidity, respiratory complications, and cardiac problems. It is a global health chall
Externí odkaz:
https://doaj.org/article/acca250bd1834b6da56848fc6ab9dcb0
Autor:
Gertrudis Rojas, Ernesto Relova-Hernández, Annia Pérez-Riverón, Camila Castro-Martínez, Osmany Diaz-Bravo, Yanelys Cabrera Infante, Tania Gómez, Joaquín Solozábal, Ana Beatriz DíazBravo, Maren Schubert, Marlies Becker, Beatriz Pérez-Massón, Dayana Pérez-Martínez, Rydell Alvarez-Arzola, Osmany Guirola, Glay Chinea, Luis Graca, Stefan Dübel, Kalet León, Tania Carmenate
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-20 (2023)
Abstract Interleukin-2 (IL-2) engineered versions, with biased immunological functions, have emerged from yeast display and rational design. Here we reshaped the human IL-2 interface with the IL-2 receptor beta chain through the screening of phage-di
Externí odkaz:
https://doaj.org/article/fc54223928184a9ab56c2dddb4e1f03a
Autor:
Sebastian Lutz, Katja Klausz, Anca-Maria Albici, Lea Ebinger, Lea Sellmer, Hannah Teipel, André Frenzel, Anna Langner, Dorothee Winterberg, Steffen Krohn, Michael Hust, Thomas Schirrmann, Stefan Dübel, Regina Scherließ, Andreas Humpe, Martin Gramatzki, Christian Kellner, Matthias Peipp
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The activating receptor natural killer group 2, member D (NKG2D) represents an attractive target for immunotherapy as it exerts a crucial role in cancer immunosurveillance by regulating the activity of cytotoxic lymphocytes. In this study, a panel of
Externí odkaz:
https://doaj.org/article/7c5953b3bdb248e2bc422fe95902d787
Autor:
Nora Langreder, Dorina Schäckermann, Doris Meier, Marlies Becker, Maren Schubert, Stefan Dübel, Thomas Reinard, Stefanie Figge-Wegener, Kristine Roßbach, Wolfgang Bäumer, Simone Ladel, Michael Hust
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Insect bite hypersensitivity (IBH) is the most common allergic skin disease of horses. It is caused by insect bites of the Culicoides spp. which mediate a type I/IVb allergy with strong involvement of eosinophil cells. No specific treatment
Externí odkaz:
https://doaj.org/article/6ff4edd772434189b50b3655420751c3
Autor:
Leila Abassi, Federico Bertoglio, Željka Mačak Šafranko, Thomas Schirrmann, Marina Greweling-Pils, Oliver Seifert, Fawad Khan, Maeva Katzmarzyk, Henning Jacobsen, Natascha Gödecke, Philip Alexander Heine, André Frenzel, Helena Nowack, Stefan Dübel, Ivan-Christian Kurolt, Roland E. Kontermann, Alemka Markotić, Maren Schubert, Michael Hust, Luka Čičin-Šain
Publikováno v:
Viruses, Vol 15, Iss 11, p 2153 (2023)
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and caused approximately 7 million deaths. While several vaccines and monoclonal antibodies (mAb) have been developed and deployed, natural selection against immune recog
Externí odkaz:
https://doaj.org/article/077b33dc2676465b9909db3b22cbe422
Autor:
Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić, Ilija Brizić, Fausto Baldanti, Lennart Hammarström, Stefan Dübel, Alan Šustić, Harold Marcotte, Monika Strengert, Alen Protić, Antonio Piralla, Qiang Pan-Hammarström, Luka Čičin-Šain, Michael Hust
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background The COVID-19 pandemic is caused by the betacoronavirus SARS-CoV-2. In November 2021, the Omicron variant was discovered and immediately classified as a variant of concern (VOC), since it shows substantially more mutations in the s
Externí odkaz:
https://doaj.org/article/17cb75193cfc490592a6d9de927249e9
Autor:
Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff, Esther Veronika Wenzel, Giulio Russo, Andrea Kröger, Linda Brunotte, Stephan Ludwig, Viola Fühner, Stefan Daniel Krämer, Stefan Dübel, Luca Varani, Günter Roth, Luka Čičin-Šain, Maren Schubert, Michael Hust
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Antibodies targeting the spike protein of coronaviruses are potential candidates for therapeutic development. Here, Bertoglio et al. use phage display to select anti-SARS-CoV-2 spike antibodies from the human naïve universal antibody gene libraries
Externí odkaz:
https://doaj.org/article/0dc5d5dbf361487e9f729846cf72c808
Autor:
Janin Korn, Dorina Schäckermann, Toni Kirmann, Federico Bertoglio, Stephan Steinke, Janyn Heisig, Maximilian Ruschig, Gertrudis Rojas, Nora Langreder, Esther Veronika Wenzel, Kristian Daniel Ralph Roth, Marlies Becker, Doris Meier, Joop van den Heuvel, Michael Hust, Stefan Dübel, Maren Schubert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Antibodies are essential tools for therapy and diagnostics. Yet, production remains expensive as it is mostly done in mammalian expression systems. As most therapeutic IgG require mammalian glycosylation to interact with the human immune sys
Externí odkaz:
https://doaj.org/article/58d50e96dc5f45bcb3f271b3937cc6e0
Autor:
Gustavo Marçal Schmidt Garcia Moreira, Sabine Gronow, Stefan Dübel, Marcelo Mendonça, Ângela Nunes Moreira, Fabricio Rochedo Conceição, Michael Hust
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Listeria monocytogenes is the causative agent of listeriosis, a highly lethal disease initiated after the ingestion of Listeria-contaminated food. This species comprises different serovars, from which 4b, 1/2a, and 1/2b cause most of the infections.
Externí odkaz:
https://doaj.org/article/686d2106314c421f85a8c4fad84822d5