Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stefan Carle"'
Autor:
Angel J. Castañeda Ruiz, Maryam A. Shetab Boushehri, Tamara Phan, Stefan Carle, Patrick Garidel, Julia Buske, Alf Lamprecht
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2575 (2022)
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports abou
Externí odkaz:
https://doaj.org/article/26eb8014fb0b47a39dabea8f265321b4
Autor:
Manuel Schuster, Leonie Schnell, Peter Feigl, Carina Birkhofer, Katharina Mohr, Maurice Roeder, Stefan Carle, Simon Langer, Franziska Tippel, Johannes Buchner, Gunter Fischer, Felix Hausch, Manfred Frick, Carsten Schwan, Klaus Aktories, Cordelia Schiene-Fischer, Holger Barth
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which
Externí odkaz:
https://doaj.org/article/ae633d2015bd44bcb353d2cd6cd6a608
Publikováno v:
ADMET and DMPK, Vol 3, Iss 3, Pp 190-202 (2015)
The transport of small molecules, peptides and proteins via the olfactory epithelium and along olfactory and trigeminal nerve pathways from the nasal cavity to the brain is very well known and clinically established for central nervous system (CNS) a
Externí odkaz:
https://doaj.org/article/23d89aec7f7b43438f43a68e63cb8326
Publikováno v:
Toxins, Vol 9, Iss 12, p 404 (2017)
The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-2
Externí odkaz:
https://doaj.org/article/331b7f78f1894972a1194ced01a71f17
Publikováno v:
Toxins, Vol 9, Iss 1, p 32 (2017)
The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation
Externí odkaz:
https://doaj.org/article/41038c3822154312845d9d7594c41dcc
Autor:
Tim Diederichs, Judith J. Mittag, James Humphrey, Söhnke Voss, Stefan Carle, Julia Buske, Patrick Garidel
Publikováno v:
International Journal of Pharmaceutics. 635:122660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa1d2d8f56df73574e764f482e3f81e
https://doi.org/10.1016/j.ijpharm.2023.122660
https://doi.org/10.1016/j.ijpharm.2023.122660
Autor:
Jens Michaelis, Manfred Frick, Stefan Carle, Holger Barth, Tanmay Sadhanasatish, Fanny Wondany, Maximilian Fellermann, Julia Nemeth
Publikováno v:
Archives of Toxicology
Diphtheria toxin (DT) efficiently inhibits protein synthesis in human cells, resulting in severe disease diphtheria. The sensitivity towards DT varies between mammalian species. Mice and rats are resistant to DT. However, the reason underlying this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691855bb1d3aeced53350c3a3bf0e3da
http://europepmc.org/articles/PMC7261736
http://europepmc.org/articles/PMC7261736
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 166
Two of the most widely used surfactants to stabilize biologicals against e.g. interfacial stresses are polysorbate 20 (PS20) and polysorbate 80 (PS80). In recent years, numerous cases of hydrolytic polysorbate (PS) degradation in liquid formulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f29bcc75f20447403f9208e03478077
https://pubmed.ncbi.nlm.nih.gov/34419573
https://pubmed.ncbi.nlm.nih.gov/34419573
Publikováno v:
International journal of pharmaceutics. 591
Two of the most widely used surfactants to stabilize biologicals against e.g. interfacial stress are polysorbate 20 (PS20) and polysorbate 80 (PS80). In recent years, polysorbate degradation in biopharmaceutical formulations has been observed. Polyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb937c756f8a743472f87725d817c0d1
https://pubmed.ncbi.nlm.nih.gov/33059015
https://pubmed.ncbi.nlm.nih.gov/33059015
Autor:
Claire Boulogne, Anne Spang, Holger Barth, Julien Barbier, Jean-Christophe Cintrat, Daniel Gillet, Yu Wu, Maria Podinovskaia, Stefan Carle
Publikováno v:
FEBS Journal
FEBS Journal, 2020, ⟨10.1111/febs.15201⟩
FEBS Journal, Wiley, 2020, ⟨10.1111/febs.15201⟩
FEBS Journal, 2020, ⟨10.1111/febs.15201⟩
FEBS Journal, Wiley, 2020, ⟨10.1111/febs.15201⟩
International audience; The endo-lysosome system is involved in endocytosis, protein sorting and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb094a3e399d4027aa68dbb5e46906d
https://hal.science/hal-02445466
https://hal.science/hal-02445466
