Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stefan Bjelosevic"'
Autor:
Hansen J. Kosasih, Gerry Healey, Margs S. Brennan, Stefan Bjelosevic, Teresa Sadras, Fatimah B. Jalud, Tasnia Ibnat, Ashley P. Ng, Chelsea Mayoh, Jie Mao, Gabor Tax, Louise E. A. Ludlow, Ricky W. Johnstone, Marco J. Herold, Seong L. Khaw, Charles E. deBock, Paul G. Ekert
Publikováno v:
HemaSphere, Vol 8, Iss 2, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/aa411753f44943afbf2d90c36c201409
Autor:
Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El-Ayoubi, Jezrael L. Revalde, Janith A. Seneviratne, Belamy B. Cheung, Laurence C. Cheung, Rishi S. Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M. Arndt, Richard B. Lock, Ricky W. Johnstone, Andrei V. Gudkov, Katerina V. Gurova, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Rearrangements of the Mixed Lineage Leukemia (MLL/KMT2A) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leuke
Externí odkaz:
https://doaj.org/article/030ef39db2a746f68cb7bcf2cf823422
Autor:
Ricky W. Johnstone, Pilar M. Dominguez, Andrew H. Wei, Andrew C. Perkins, Steven W. Lane, Benjamin T. Kile, Sammy Bedoui, Stefanie Scheu, Daniel D. De Carvalho, Stephin J. Vervoort, Lev M. Kats, Paul J. Hertzog, Simon J. Hogg, Madison J. Kelly, Jens Lichte, Nicole A. de Weerd, Elise Gressier, Antony Y. Matthews, Kate McArthur, Eva Vidacs, Veronique Litalien, Peter J. Fraser, Leonie A. Cluse, Stefan Bjelosevic, Michael Bots, Magnus Zethoven, Gisela Mir Arnau, Timothy Semple, Fernando Rossello, Luciano G. Martelotto, Conor J. Kearney, Claudia Bruedigam, Kym L. Stanley, Izabela Todorovski, Jessica M. Salmon
Supplementary Table from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e300e9dab924649a78f87b56e378e4
https://doi.org/10.1158/2159-8290.22541176
https://doi.org/10.1158/2159-8290.22541176
Autor:
Ricky W. Johnstone, Pilar M. Dominguez, Andrew H. Wei, Andrew C. Perkins, Steven W. Lane, Benjamin T. Kile, Sammy Bedoui, Stefanie Scheu, Daniel D. De Carvalho, Stephin J. Vervoort, Lev M. Kats, Paul J. Hertzog, Simon J. Hogg, Madison J. Kelly, Jens Lichte, Nicole A. de Weerd, Elise Gressier, Antony Y. Matthews, Kate McArthur, Eva Vidacs, Veronique Litalien, Peter J. Fraser, Leonie A. Cluse, Stefan Bjelosevic, Michael Bots, Magnus Zethoven, Gisela Mir Arnau, Timothy Semple, Fernando Rossello, Luciano G. Martelotto, Conor J. Kearney, Claudia Bruedigam, Kym L. Stanley, Izabela Todorovski, Jessica M. Salmon
Supplementary Figure from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f605327aef75ec2cfc901c81df1fb6
https://doi.org/10.1158/2159-8290.22541194
https://doi.org/10.1158/2159-8290.22541194
Autor:
Izabela Todorovski, Breon Feran, Zheng Fan, Sreeja Gadipally, David Yoannidis, Isabella Y Kong, Stefan Bjelosevic, Magnus Zethoven, Edwin D Hawkins, Kaylene J Simpson, Gisela Mir Arnau, Anthony T Papenfuss, Ricky W Johnstone, Stephin J Vervoort
Therapeutic targeting of dysregulated transcriptional programs has arisen as a promising strategy for the treatment of leukaemias. The therapeutic response to small molecule inhibitors of Bromodomain-Containing Proteins (BRD), such as BRD2 and BRD4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d24166ee060968f3ff025acbde0431
https://doi.org/10.1101/2022.04.06.487057
https://doi.org/10.1101/2022.04.06.487057
SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia
Autor:
Lauren M. Brown, Soroor Hediyeh-zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J. Sandow, Ray C. Bartolo, Hansen J. Kosasih, Nadia M. Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew I. Webb, Seong L. Khaw, Alicia Oshlack, Melissa J. Davis, Paul G. Ekert
Publikováno v:
Blood advances. 6(7)
Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expression profile resembling Philadelphia chromosome–positive ALL (Ph+ ALL) in the absence of BCR-ABL1. Tyrosine kinase–a
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
Autor:
Magnus Zethoven, Conor J. Kearney, Matteo Costacurta, Izabela Todorovski, Alessandro Gardini, Michael Ohlmeyer, Stefan Bjelosevic, Gareth P. Gregory, Deborah A. Knight, Nathanael S. Gray, Jarrod J. Sandow, Sarah A. Welsh, Elisa Barbieri, Andrea Newbold, Madison J. Kelly, Otto Kauko, Sarah Offley, Joseph H.A. Vissers, Benjamin J. Blyth, Stephin J. Vervoort, Kaylene J. Simpson, Ben P. Martin, Ricky W. Johnstone, Jukka Westermarck, Jennifer R. Devlin, Kieran F. Harvey, Karolina Pavic, Edwin D. Hawkins, Elena Demosthenous, Isabella Y. Kong, Zheng Fan, Victoria McLeod, Simon J. Hogg
Publikováno v:
Cell
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint following transcription initiation is primarily controlled by CDK9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f96a12e3df6259f7ff40c0a9115141a
https://europepmc.org/articles/PMC8567840/
https://europepmc.org/articles/PMC8567840/
Autor:
Seong Lin Khaw, Nadia May Davidson, Ricky W. Johnstone, Gabriela Brumatti, Paul G Ekert, Stefan Bjelosevic, Hansen J. Kosasih, Margs S. Brennan, Emma Morrish, Alicia Oshlack
Publikováno v:
Blood Adv
Key Points A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient. MLL-TFE3 expression produces aggressive leukemia in a mouse model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd94b2818e2154b7cb001e34b331e1
https://europepmc.org/articles/PMC7556123/
https://europepmc.org/articles/PMC7556123/
Autor:
Jessica M. Salmon, Izabela Todorovski, Kym L. Stanley, Claudia Bruedigam, Conor J. Kearney, Luciano G. Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A. Cluse, Peter J. Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y. Matthews, Elise Gressier, Nicole A. de Weerd, Jens Lichte, Madison J. Kelly, Simon J. Hogg, Paul J. Hertzog, Lev M. Kats, Stephin J. Vervoort, Daniel D. De Carvalho, Stefanie Scheu, Sammy Bedoui, Benjamin T. Kile, Steven W. Lane, Andrew C. Perkins, Andrew H. Wei, Pilar M. Dominguez, Ricky W. Johnstone
Publikováno v:
Cancer discovery. 12(6)
Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addition to affecting tumor cell growth and proliferation, these epigenetic agents may induce antitumor immunity. Here, we discovered a n
Autor:
Conor J. Kearney, Joep Vissers, Ben P. Martin, Ricky W. Johnstone, Stefan Bjelosevic, Zheng Fan, Matteo Costacurta, Jennifer R. Devlin, Karolina Pavic, Michael Ohlmeyer, Sarah A. Welsh, Jarrod J. Sandow, Nathanael S. Gray, Otto Kauko, Gareth P. Gregory, Stephin J. Vervoort, Simon J. Hogg, Andrea Newbold, Isabella Y. Kong, Kaylene J. Simpson, Deborah A. Knight, Izabela Todorovski, Elisa Barbieri, Kieran F. Harvey, Madison J. Kelly, Alessandro Gardini, Edwin D. Hawkins, Jukka Westermarck
SUMMARYGene expression is tightly controlled by Cyclin-dependent kinases (CDKs) which regulate the RNA Polymerase II (RNAPII) transcription cycle at discrete checkpoints. RNAPII pausing is a CDK9-controlled rate-limiting process that occurs shortly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb7dc1e286f1dcefae476501fb5a0246
https://doi.org/10.1101/2020.07.12.199372
https://doi.org/10.1101/2020.07.12.199372