Výsledky vyhledávání - "Stefan Bauernfried"

Publikováno v: Nature Structural & Molecular Biology. 28:333-336

NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and

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https://doi.org/10.1038/s41594-021-00580-y

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Human NLRP1 is activated by ZAKɑ-driven ribotoxic stress response

Autor: Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Shima Bayat, Zijin Sun, Stefan Bauernfried, Rhea Nadkarni, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Kiat Yi Tan, Carine Bonnard, Radoslaw Sobota, John E. Connolly, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Veit Hornung, Franklin L. Zhong

Human NLRP1 is a multifunctional inflammasome sensor predominantly expressed in skin and airway epithelium; however its function in skin-specific immunity and its mechanisms of activation are not fully understood. Here we report that human NLRP1 is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::528d68a0f807bf495e55628698a44052
https://doi.org/10.1101/2022.01.24.477516

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CARD8 inflammasome activation triggers pyroptosis in human T cells

Autor: Veit Hornung, Yiming Cheng, Andreas Linder, Stefan Bauernfried, Christophe Jung, Oliver T. Keppler, Manuel Albanese

Publikováno v: The EMBO Journal

Inflammasomes execute a unique type of cell death known as pyroptosis. Mostly characterized in myeloid cells, caspase‐1 activation downstream of an inflammasome sensor results in the cleavage and activation of gasdermin D (GSDMD), which then forms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71f3f43dbfe744e9f570acfab59552f
http://europepmc.org/articles/PMC7527815

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C-tag TNF: a reporter system to study TNF shedding

Autor: Francesca Pinci, Gunnar Kuut, Margaret A Jackson, Christophe Jung, Stefan Bauernfried, Veit Hornung, Moritz M. Gaidt

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry

TNF is a highly pro-inflammatory cytokine that contributes not only to the regulation of immune responses but also to the development of severe inflammatory diseases. TNF is synthesized as a transmembrane protein, which is further matured via proteol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15342a6bac1aa2f78cb1ebceb539771
https://pubmed.ncbi.nlm.nih.gov/33082141

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Human NLRP1 is a sensor for double-stranded RNA

Autor: Stefan Bauernfried, Andreas Pichlmair, Matthias J. Scherr, Karl E. Duderstadt, Veit Hornung

Publikováno v: Science

A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers the formation of signaling complexes called inflammasomes. These complexes then initiate pyroptosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4449b1df8d9df190e489340886180b
https://pubmed.ncbi.nlm.nih.gov/33545058

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The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

Autor: Stefan Bauernfried, Veit Hornung, Oliver T. Keppler, Hanna-Mari Baldauf, Oliver T. Fackler, Pedro J. Esteves, Virginia Pierini, Massimo Pizzato, Patrícia de Sousa-Pereira, Joana Abrantes

Publikováno v: J. Gen. Virol. 100, 278-288 (2019)

A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99348f133c6c39080497adcd9939206d
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55452

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Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists

Autor: Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl‐Peter Hopfner, Veit Hornung, Lars M. König, Thomas Carell

Publikováno v: Angewandte Chemie International Edition

2',3'-cGAMP is a cyclic A- and G-containing dinucleotide second messenger, which is formed upon cellular recognition of foreign cytosolic DNA as part of the innate immune response. The molecule binds to the adaptor protein STING, which induces an imm

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