Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stefan Bartoschek"'
Autor:
Geoffrey Férir, Mariya I Petrova, Graciela Andrei, Dana Huskens, Bart Hoorelbeke, Robert Snoeck, Jos Vanderleyden, Jan Balzarini, Stefan Bartoschek, Mark Brönstrup, Roderich D Süssmuth, Dominique Schols
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64010 (2013)
Lantibiotics are peptides, produced by bacteria, that contain the noncanonical amino acid lanthionine and many of them exhibit antibacterial activities. The labyrinthopeptin A1 (LabyA1) is a prototype peptide of a novel class of carbacyclic lantibiot
Externí odkaz:
https://doaj.org/article/872bea6f6dfd45b8b8ca202f5c18c5d9
Publikováno v:
Business Planning im Gesundheitswesen ISBN: 9783658081850
Das dritte Kapitel widmet sich der Frage, wie man die Attraktivitat eines neuen Produktes bzw. einer neuen Dienstleistung fur den, der sie nutzen (und bezahlen) soll erkennt. Zudem geht es naher darauf ein, welche Art von Nutzen am wichtigsten im Ges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e099c0585bd84196558820dbbfc8dd7
https://doi.org/10.1007/978-3-658-08186-7_3
https://doi.org/10.1007/978-3-658-08186-7_3
Publikováno v:
Future Medicinal Chemistry. 4:869-875
Drug discovery on membrane proteins is still a difficult task, despite the recognized importance of membrane proteins as drug targets. Here, we present an overview of NMR methods available for structure-based drug design on membrane proteins. NMR spe
Publikováno v:
Journal of Biomolecular Nmr
Journal of Biomolecular NMR
Journal of Biomolecular NMR
Low-affinity ligands can be efficiently optimized into high-affinity drug leads by structure based drug design when atomic-resolution structural information on the protein/ligand complexes is available. In this work we show that the use of a few, eas
Autor:
Bettina Elshorst, Gerhard Hessler, Alexander Schiffer, Isabelle Krimm, Thomas Langer, Donghan Lee, Stefan Bartoschek, Adam Mazur, Peter Monecke, Christian Griesinger, Jens Pilger, Herman Schreuder, K-Ulrich Wendt, Stefan Becker, Melanie Wegstroth
Publikováno v:
Angewandte Chemie
Angewandte Chemie, Wiley-VCH Verlag, 2015, 54 (22), pp.6511-6515. ⟨10.1002/anie.201500671⟩
Angewandte Chemie International Edition
Angewandte Chemie, Wiley-VCH Verlag, 2015, 54 (22), pp.6511-6515. ⟨10.1002/anie.201500671⟩
Angewandte Chemie International Edition
We thank Sandra Schimanski-Breves and Alexander Liesum for crystallization, Dirk Bossemeyer and Michael Gassel for protein production of PKA.; International audience; Structure-based drug design (SBDD) is a powerful and widely used approach to optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4722c0ab9ba3f3847d29d0db92064d
https://hal.archives-ouvertes.fr/hal-01165216
https://hal.archives-ouvertes.fr/hal-01165216
Autor:
Stefan Bartoschek, Christian Griesinger, Bernhard H. Geierstanger, Rudolf K. Thauer, Gerrit Buurman, Michael Nilges, Jan P. Weyrauch, Volkhard Helms, Michael C. Hutter
Publikováno v:
ChemBioChem. 2:530-541
Four different dehydrogenases are known that catalyse the reversible dehydrogenation of N5,N10-methylenetetrahydromethanopterin (methylene-H4MPT) or N5,N10-methylenetetrahydrofolate (methylene-H4F) to the respective N5,N10-methenyl compounds. Sequenc
Autor:
Julia A. Vorholt, Christian Griesinger, Stefan Bartoschek, Rudolf K. Thauer, Christoph H. Hagemeier
Publikováno v:
FEBS Letters. 494:95-98
MtdA catalyzes the dehydrogenation of N 5 , N 10 -methylenetetrahydromethanopterin (methylene-H 4 MPT) with NADP + as electron acceptor. In the reaction two prochiral centers are involved, C14a of methylene-H 4 MPT and C4 of NADP + , between which a
Autor:
Pierre-Loïc Saaidi, Florent Di Meo, Hans-Peter Fiedler, Stefan Bartoschek, Vivien Schubert, P. Trouillas, Roderich D. Süssmuth
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 20(17)
Skyllamycin is a non-ribosomally synthesized cyclic depsipeptide from Streptomyces sp. Acta 2897 that inhibits PDGF-signaling. The peptide scaffold contains an N-terminal cinnamoyl moiety, a β-methylation of aspartic acid, three β-hydroxylated amin
Autor:
Julia A. Vorholt, Rudolf K. Thauer, Bernhard H. Geierstanger, Christian Griesinger, Stefan Bartoschek
Publikováno v:
European Journal of Biochemistry. 267:3130-3138
N-carboxymethanofuran (carbamate) formation from unprotonated methanofuran (MFR) and CO2 is the first reaction in the reduction of CO2 to methane in methanogenic archaea. The reaction proceeds spontaneously. We address here the question whether the r
Autor:
Stefan Bartoschek, Siegfried Stengelin, Christian Griesinger, K. Ulrich Wendt, Teresa Carlomagno, Viktoria Dietrich, Thomas Klabunde, Ingo Focken, Elisabeth Defossa
Publikováno v:
Angewandte Chemie (International ed. in English). 49(8)