Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Stefan A. Muljo"'
Publikováno v:
Non-Coding RNA, Vol 9, Iss 6, p 75 (2023)
Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cell
Externí odkaz:
https://doaj.org/article/9c92be9f037e45609ffede837441c24f
Autor:
Anju Singh, Myagmarjav Dashynam, Bryan Chim, Thelma M. Escobar, Xiuhuai Liu, Xin Hu, Samarjit Patnaik, Xin Xu, Noel Southall, Juan Marugan, Ajit Jadhav, Vanja Lazarevic, Stefan A. Muljo, Marc Ferrer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases. Small molecules that can modulate m
Externí odkaz:
https://doaj.org/article/28cf79f1b82146509af8f9f2b2558447
Autor:
Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109911- (2021)
Summary: Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of na
Externí odkaz:
https://doaj.org/article/0c8c5ea249b7400aa1ce379f1a846ac3
Autor:
Yun Ji, Jessica Fioravanti, Wei Zhu, Hongjun Wang, Tuoqi Wu, Jinhui Hu, Neal E. Lacey, Sanjivan Gautam, John B. Le Gall, Xia Yang, James D. Hocker, Thelma M. Escobar, Shan He, Stefania Dell’Orso, Nga V. Hawk, Veena Kapoor, William G. Telford, Luciano Di Croce, Stefan A. Muljo, Yi Zhang, Vittorio Sartorelli, Luca Gattinoni
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD
Externí odkaz:
https://doaj.org/article/f7106871939f484092d79cd389893db3
Autor:
Chryssa Kanellopoulou, Timothy Gilpatrick, Gokhul Kilaru, Patrick Burr, Cuong K. Nguyen, Aaron Morawski, Michael J. Lenardo, Stefan A. Muljo
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 971-978 (2015)
Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of differentiation, pluripotency, and proliferation of ESCs, but the molecular program that they control ha
Externí odkaz:
https://doaj.org/article/9fbba6fedbef453bbdf7719e0ce71e95
Autor:
Chrysi Kanellopoulou, Stefan A. Muljo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
How a single genome can give rise to many different transcriptomes and thus all the different cell lineages in the human body is a fundamental question in biology. While signaling pathways, transcription factors, and chromatin architecture, to name a
Externí odkaz:
https://doaj.org/article/66b87d930804454f9ea74cd2fc8f5c1b
Autor:
Djem U Kissiov, Alexander Ethell, Sean Chen, Natalie K Wolf, Chenyu Zhang, Susanna M Dang, Yeara Jo, Katrine N Madsen, Ishan Paranjpe, Angus Y Lee, Bryan Chim, Stefan A Muljo, David H Raulet
Publikováno v:
eLife, Vol 11 (2022)
Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural kil
Externí odkaz:
https://doaj.org/article/9505cd27acaf469ab8f89ecc6921b8c0
Autor:
Djem U. Kissiov, Alexander Ethell, Sean Chen, Natalie K. Wolf, Chenyu Zhang, Susanna M. Dang, Yeara Jo, Katrine N. Madsen, Ishan D. Paranjpe, Angus Y. Lee, Bryan Chim, Stefan A. Muljo, David H. Raulet
Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural kil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe4fd273b954900c9193ef9f401b76e
https://escholarship.org/uc/item/6wj2k8bw
https://escholarship.org/uc/item/6wj2k8bw
Autor:
Djem U Kissiov, Alexander Ethell, Sean Chen, Natalie K Wolf, Chenyu Zhang, Susanna M Dang, Yeara Jo, Katrine N Madsen, Ishan Paranjpe, Angus Y Lee, Bryan Chim, Stefan A Muljo, David H Raulet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13609246c5b1580a08ccec78b586b98a
https://doi.org/10.7554/elife.74204.sa2
https://doi.org/10.7554/elife.74204.sa2
Autor:
Zhenqiu Liu, Vikash Singh, Qingli Lu, Irina Elcheva, Vladimir S. Spiegelman, Stefan A. Muljo, Markus Hafner, Tyler Wood, Madeline Wong, Chethana P. Gowda, Bryan Chim, Sinisa Dovat, Kathryn Chiarolanzio
Publikováno v:
Leukemia
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating pot