Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefan A. Fattinger"'
Autor:
Chantal Ernst, Patrick R Andreassen, Gabriel H Giger, Bidong D Nguyen, Christoph G Gäbelein, Orane Guillaume-Gentil, Stefan A Fattinger, Mikael E Sellin, Wolf-Dietrich Hardt, Julia A Vorholt
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002597 (2024)
Intestinal epithelial cells (IECs) play pivotal roles in nutrient uptake and in the protection against gut microorganisms. However, certain enteric pathogens, such as Salmonella enterica serovar Typhimurium (S. Tm), can invade IECs by employing flage
Externí odkaz:
https://doaj.org/article/be0194b104fc4fb58354f7d0ece570b5
Autor:
Ersin Gül, Erik Bakkeren, Guillem Salazar, Yves Steiger, Andrew Abi Younes, Melanie Clerc, Philipp Christen, Stefan A Fattinger, Bidong D Nguyen, Patrick Kiefer, Emma Slack, Martin Ackermann, Julia A Vorholt, Shinichi Sunagawa, Médéric Diard, Wolf-Dietrich Hardt
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002253 (2023)
Salmonella Typhimurium elicits gut inflammation by the costly expression of HilD-controlled virulence factors. This inflammation alleviates colonization resistance (CR) mediated by the microbiota and thereby promotes pathogen blooms. However, the inf
Externí odkaz:
https://doaj.org/article/0705fa0df8294147aa7c06260a842924
Autor:
Ersin Gül, Ursina Enz, Luca Maurer, Andrew Abi Younes, Stefan A Fattinger, Bidong D Nguyen, Annika Hausmann, Markus Furter, Manja Barthel, Mikael E Sellin, Wolf-Dietrich Hardt
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011235 (2023)
Recruitment of neutrophils into and across the gut mucosa is a cardinal feature of intestinal inflammation in response to enteric infections. Previous work using the model pathogen Salmonella enterica serovar Typhimurium (S.Tm) established that invas
Externí odkaz:
https://doaj.org/article/eba57bd740684b71a7c87e04baa65b1d
Autor:
Stefan A Fattinger, Desirée Böck, Maria Letizia Di Martino, Sabrina Deuring, Pilar Samperio Ventayol, Viktor Ek, Markus Furter, Saskia Kreibich, Francesco Bosia, Anna A Müller-Hauser, Bidong D Nguyen, Manfred Rohde, Martin Pilhofer, Wolf-Dietrich Hardt, Mikael E Sellin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008503 (2020)
Salmonella enterica serovar Typhimurium (S.Tm) infections of cultured cell lines have given rise to the ruffle model for epithelial cell invasion. According to this model, the Type-Three-Secretion-System-1 (TTSS-1) effectors SopB, SopE and SopE2 driv
Externí odkaz:
https://doaj.org/article/5a9d7e06a10540bb8d6ba0e1370f2e5b
Autor:
Ersin Gül, Stefan A. Fattinger, Bidong D. Nguyen, Annika Hausmann, Markus Furter, Manja Barthel, Mikael E. Sellin, Wolf-Dietrich Hardt
SummaryRecruitment of neutrophils into the gut epithelium is a cardinal feature of intestinal inflammation in response to enteric infections. Previous work using the model pathogenSalmonellaTyphimurium (S. Tm) established that invasion of intestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54680d53e9bbf3e8ab3d8b965bbd7c4d
https://doi.org/10.1101/2023.02.23.529832
https://doi.org/10.1101/2023.02.23.529832
Autor:
Stefan A. Fattinger, Luca Maurer, Petra Geiser, Ursina Enz, Suwannee Ganguillet, Ersin Gül, Sanne Kroon, Benjamin Demarco, Markus Furter, Manja Barthel, Pawel Pelczar, Feng Shao, Petr Broz, Mikael E. Sellin, Wolf-Dietrich Hardt
Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores are hallmarks of a specific form of cell death called pyroptosis and mediate the secretion of pro-inflammatory cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afdeb608f0d0a519230fc61f6bd4a9a4
https://doi.org/10.1101/2022.11.24.517575
https://doi.org/10.1101/2022.11.24.517575
Autor:
Verena Lentsch, Aurore Woller, Claudia Moresi, Stefan A. Fattinger, Selma Aslani, Wolf-Dietrich Hardt, Claude Loverdo, Médéric Diard, Emma Slack
Publikováno v:
bioRxiv
Widespread antimicrobial resistance generates an urgent need to develop better disease prophylaxis for intestinal bacterial pathogens. While the first phase of infection with any bacterial pathogen is typically colonization of the mucosal surfaces, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d259dffb636662330d39f61f84221ee8
https://doi.org/10.1101/2022.07.20.498444
https://doi.org/10.1101/2022.07.20.498444
Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
Publikováno v:
Current Opinion in Microbiology, 64
Salmonella Typhimurium (S.Tm) is a major cause of diarrheal disease. The invasion into intestinal epithelial cells (IECs) is a central step in the infection cycle. It is associated with gut inflammation and thought to benefit S.Tm proliferation also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944d9e1253a92232a3ea99516edfa965
https://hdl.handle.net/20.500.11850/505283
https://hdl.handle.net/20.500.11850/505283
Autor:
Katerina Vlantis, Danijela Heide, Boas Felmy, Giverny Ganz, Stefan A. Fattinger, Leo Kunz, Tamas Dolowschiak, Ioana Sandu, Nathan Sébastien Zangger, Mikael E. Sellin, Wolf-Dietrich Hardt, Yang Zhang, Anna A. Müller-Hauser, Annika Hausmann, Luigi Tortola, Jan Kisielow, Manja Barthel, Timm Schroeder, Mathias Heikenwalder, Annette Oxenius, Toshihiro Nakamura, Laurens Wachsmuth, Dorothée L. Berthold, Manfred Kopf, Sanne Kroon, Markus Furter, Manolis Pasparakis
Publikováno v:
Journal of Experimental Medicine, 218 (11)
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Hausmann et al. describe a sentinel intercrypt macrophage population in the intestine, which detects Gram-negative microbes breaching the epithelial barrier and elicits epithelial NF-κB signaling in neighboring crypts. The tunability of this crypt-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cb905c54babb757e47720669dd85f1
https://hdl.handle.net/20.500.11850/506409
https://hdl.handle.net/20.500.11850/506409
Publikováno v:
Current Opinion in Microbiology, 59
The gut epithelium prevents bacterial access to the host's tissues and coordinates a number of mucosal defenses. Here, we review the function of epithelial inflammasomes in the infected host and focus on their role in defense against Salmonella Typhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b66e66607b6006e3b0fedfdad6d344f
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438803
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438803