Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Stefan Senger"'
Autor:
Stefan Senger
Publikováno v:
Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-8 (2017)
Abstract Background Patents are an important source of information for effective decision making in drug discovery. Encouragingly, freely accessible patent-chemistry databases are now in the public domain. However, at present there is still a wide ga
Externí odkaz:
https://doaj.org/article/9b5ceb4f79804a14aa84558181810b06
Autor:
Ryan A. Miller, Peter Woollard, Egon L. Willighagen, Daniela Digles, Martina Kutmon, Antonis Loizou, Andra Waagmeester, Stefan Senger, Chris T. Evelo
Publikováno v:
F1000Research, Vol 7 (2018)
Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathw
Externí odkaz:
https://doaj.org/article/3037cd61029b4da4a0e7b7123443baa6
Autor:
Darren V. S. Green, David Brett, David Marcus, Stephen D. Pickett, Adam Powell, Jamel Meslamani, Jonathan Masson, Stefan Senger, Christopher N. Luscombe
Publikováno v:
J Comput Aided Mol Des
Journal of Computer-Aided Molecular Design
Journal of Computer-Aided Molecular Design
This paper introduces BRADSHAW (BiologicalResponseAnalysis andDesignSystem using anHeterogenous,AutomatedWorkflow), a system for automated molecular design which integrates methods for chemical structure generation, experimental design, active learni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e366049c253c407dca94b77b2e8f6
https://doi.org/10.1007/s10822-019-00234-8
https://doi.org/10.1007/s10822-019-00234-8
Autor:
Joseline Ratnam, Barbara Zdrazil, Daniela Digles, Emiliano Cuadrado-Rodriguez, Jean-Marc Neefs, Hannah Tipney, Ronald Siebes, Andra Waagmeester, Glyn Bradley, Chau Han Chau, Lars Richter, Jose Brea, Chris T Evelo, Edgar Jacoby, Stefan Senger, Maria Isabel Loza, Gerhard F Ecker, Christine Chichester
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115460 (2014)
Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidde
Externí odkaz:
https://doaj.org/article/c1affc6cc2544706bec5f96b4cf53af7
Autor:
Stefan Senger, Núria Queralt-Rosinach, L. Bartek, B. Roibás, Andrei Caracoti, N. I. Franklin, Daniela Digles, Jean-Marc Neefs, C. Herhaus, José Brea, Anna Gaulton, D. Marren, Chris T. Evelo, Ola Engkvist, Edgar Jacoby, Christine Chichester, Barbara Zdrazil, Gerhard F. Ecker, María Isabel Loza, Laura I. Furlong, H.W.T. (Herman) van Vlijmen
Publikováno v:
Medchemcomm, 7(6), 1237-1244. Royal Society of Chemistry
Med. Chem. Commun.
Recercat. Dipósit de la Recerca de Catalunya
instname
Med. Chem. Commun.
Recercat. Dipósit de la Recerca de Catalunya
instname
Phenotypic screening is in a renaissance phase and is expected by many academic and industry leaders to accelerate the discovery of new drugs for new biology. Given that phenotypic screening is per definition target agnostic, the emphasis of in silic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa604f5fc023ca090763d72f3802c484
https://cris.maastrichtuniversity.nl/en/publications/d9ac40ee-f19e-42c7-b930-a6408d398d5b
https://cris.maastrichtuniversity.nl/en/publications/d9ac40ee-f19e-42c7-b930-a6408d398d5b
Autor:
David Marcus, Jamel Meslamani, Stephen D. Pickett, Stefan Senger, Darren V. S. Green, Christopher N. Luscombe, Adam Powell, David Brett, Jonathan Masson
Publikováno v:
Journal of Computer-Aided Molecular Design. 34:767-767
The original version of this article unfortunately contained some mistakes in the references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d34d37e476b1a9470edb5532f0fb197
https://doi.org/10.1007/s10822-019-00243-7
https://doi.org/10.1007/s10822-019-00243-7
Publikováno v:
Journal of Chemical Information and Modeling. 52:757-769
Molecular interaction fields provide a useful description of ligand binding propensity and have found widespread use in computer-aided drug design, for example, to characterize protein binding sites and in small molecular applications, such as three-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551f04dad87ca0e7487bf3c5ffa6420e
https://doi.org/10.1021/ci200348h
https://doi.org/10.1021/ci200348h
Autor:
Stefan Senger, Máire A. Convery, Robert J. Young, Stephanie Irvine, Iain M. McLay, Robert I. West, David J. Belton, Savvas Kleanthous, Carl Adams, John R. Toomey, Anne M. Exall, Anthony J. Pateman, Theresa J. Roethke, Caroline M. Whittaker, Laiq Chaudry, David E. Davies, Angela Patikis, Cynthia L. Burns-Kurtis, Nigel S. Watson, Gary J. Stelman, David W. Brown, John D. Harling, Wendy R. Irving, Chuen Chan, Ping Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1588-1592
The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff85f937ce4e89e1a2bcffaac9ddca4
https://doi.org/10.1016/j.bmcl.2011.01.129
https://doi.org/10.1016/j.bmcl.2011.01.129
Publikováno v:
Psychiatrie und Psychotherapie up2date. 5:113-128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637c4f96bddd8eba5ee9162229a9e83e
https://doi.org/10.1055/s-0030-1266014
https://doi.org/10.1055/s-0030-1266014
Autor:
Stefan Senger, Chris T. Evelo, Ryan A. Miller, Peter Woollard, Daniela Digles, Egon Willighagen, Antonis Loizou, Martina Kutmon, Andra Waagmeester
Publikováno v:
F1000Research
Open PHACTS is a pre-competitive project to answer scientific questions developed recently by the pharmaceutical industry. Having high quality biological interaction information in the Open PHACTS Discovery Platform is needed to answer multiple pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871e29690ddd99b060ace7629d338e6f
https://doi.org/10.12688/f1000research.13197.2
https://doi.org/10.12688/f1000research.13197.2