Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis

Autor: Mattheus H. E. Wildschut, Julien Mena, Cyril Dördelmann, Marc van Oostrum, Benjamin D. Hale, Jens Settelmeier, Yasmin Festl, Veronika Lysenko, Patrick M. Schürch, Alexander Ring, Yannik Severin, Michael S. Bader, Patrick G. A. Pedrioli, Sandra Goetze, Audrey van Drogen, Stefan Balabanov, Radek C. Skoda, Massimo Lopes, Bernd Wollscheid, Alexandre P. A. Theocharides, Berend Snijder

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. Myelofibrosis patients frequently carry driver mutations in either JAK2 or Calreticulin (CALR) and have limited therapeutic options. Here, we

Externí odkaz: https://doaj.org/article/be42116607d44feb831a5d12924ccd1b

Anticancer Activity of the Marine Triterpene Glycoside Cucumarioside A2-2 in Human Prostate Cancer Cells

Autor: Ekaterina S. Menchinskaya, Sergey A. Dyshlovoy, Simone Venz, Christine Jacobsen, Jessica Hauschild, Tina Rohlfing, Aleksandra S. Silchenko, Sergey A. Avilov, Stefan Balabanov, Carsten Bokemeyer, Dmitry L. Aminin, Gunhild von Amsberg, Friedemann Honecker

Publikováno v: Marine Drugs, Vol 22, Iss 1, p 20 (2023)

Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), treatment is inevitably hampered by the development of drug resistance. Thus, new drugs are urgently needed. We investigated the efficacy, toxicity, a

Externí odkaz: https://doaj.org/article/ef96dfc1e6784c86a537b7ae846cbe5e

BRAF inhibitor treatment of classical hairy cell leukemia allows successful vaccination against SARS-CoV-2

Autor: Judith Konrat, Wiebke Rösler, Michael Roiss, Fabienne Meier-Abt, Corinne C. Widmer, Stefan Balabanov, Markus G. Manz, Thorsten Zenz

Publikováno v: Annals of hematology.

In classical hairy cell leukemia (HCL), standard treatments including purine analogs achieve a durable response (up to 90%), but lead to severe immunosuppression and long-lasting depletion of CD4 + T lymphocytes. The BRAF inhibitor vemurafenib is eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3506d7a426e63addc27bf7ade6978c03
https://pubmed.ncbi.nlm.nih.gov/36494600

PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial

Autor: Josée M. Zijlstra, Stefan Balabanov, Carsten Kobe, Hans Theodor Eich, Richard Greil, Julia Meissner, Alden A. Moccia, Teresa V Halbsguth, Volker Diehl, Paul J Bröckelmann, Judith Dierlamm, Ulrich Keller, Bastian von Tresckow, Christian Baues, Michael Fuchs, Annette Plütschow, Helmut Ostermann, Simone Marnitz, Martin Wilhelm, Sonja Martin, Beate Klimm, Julia Thiemer, Peter Borchmann, Thomas Pabst, Johannes Mohm, Michael Hallek, Andreas Rosenwald, Markus Dietlein, Andreas Hüttmann, Martin Vogelhuber, Max S. Topp, Martin Sökler, Andreas Engert, Andrea Kerkhoff, Miriam Ahlborn, Georg Kuhnert

Publikováno v: The Lancet Oncology, 22(2), 223-234. Lancet Publishing Group
Borchmann, P, Plütschow, A, Kobe, C, Greil, R, Meissner, J, Topp, M S, Ostermann, H, Dierlamm, J, Mohm, J, Thiemer, J, Sökler, M, Kerkhoff, A, Ahlborn, M, Halbsguth, T V, Martin, S, Keller, U, Balabanov, S, Pabst, T, Vogelhuber, M, Hüttmann, A, Wilhelm, M, Zijlstra, J M, Moccia, A, Kuhnert, G, Bröckelmann, P J, von Tresckow, B, Fuchs, M, Klimm, B, Rosenwald, A, Eich, H, Baues, C, Marnitz, S, Hallek, M, Diehl, V, Dietlein, M & Engert, A 2021, ' PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17) : a multicentre, open-label, randomised, phase 3 trial ', The Lancet Oncology, vol. 22, no. 2, pp. 223-234 . https://doi.org/10.1016/S1470-2045(20)30601-X
Strahlentherapie Und Onkologie

Background: Combined-modality treatment consisting of chemotherapy and consolidation radiotherapy is standard of care for patients with early-stage unfavourable Hodgkin lymphoma. However, the use of radiotherapy can have long-term sequelae, which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f13d466acfe65ac8d5c77ff231c4382
https://doi.org/10.1016/s1470-2045(20)30601-x

Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

Autor: Benjamin Werner, Fabian Beier, Sebastian Hummel, Stefan Balabanov, Lisa Lassay, Thorsten Orlikowsky, David Dingli, Tim H Brümmendorf, Arne Traulsen

Publikováno v: eLife, Vol 4 (2015)

We investigate the in vivo patterns of stem cell divisions in the human hematopoietic system throughout life. In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. Our mathematical mode

Externí odkaz: https://doaj.org/article/ee6ccd70808b4901b2cb8518dd1b1514