Zobrazeno 1 - 10
of 541
pro vyhledávání: '"Stefan Ambs"'
Autor:
Godfrey Wagutu, John Gitau, Kennedy Mwangi, Mary Murithi, Elias Melly, Alexandra R. Harris, Shahin Sayed, Stefan Ambs, Francis Makokha
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe immune response against tumors relies on distinguishing between self and non-self, the basis of cancer immunotherapy. Neoantigens from somatic mutations are central to many immunotherapeutic strategies and understanding their landscape
Externí odkaz:
https://doaj.org/article/e10c13d1c1a4429d876119692daf217c
Autor:
Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Ran Tao, Christine Ambrosone, Dezheng Huo, Stefan Ambs, Mollie E. Barnard, Yu Chen, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Esther M. John, Christopher I. Li, Katherine Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Toshio Yoshimatsu, Prisca O. Adejumo, Thomas Ahearn, Abenaa M. Brewster, Anselm J. M. Hennis, Timothy Makumbi, Paul Ndom, Katie M. O’Brien, Andrew F. Olshan, Mojisola M. Oluwasanu, Sonya Reid, Song Yao, Ebonee N. Butler, Maosheng Huang, Atara Ntekim, Bingshan Li, Melissa A. Troester, Julie R. Palmer, Christopher A. Haiman, Jirong Long, Wei Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes. We built geneti
Externí odkaz:
https://doaj.org/article/b9834eb3a0344dc2a7b7b629b0f35afc
Autor:
Tsion Zewdu Minas, Brittany D. Lord, Amy L. Zhang, Julián Candia, Tiffany H. Dorsey, Francine S. Baker, Wei Tang, Maeve Bailey-Whyte, Cheryl J. Smith, Obadi M. Obadi, Anuoluwapo Ajao, Symone V. Jordan, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Ann W. Hsing, Jia Liu, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from G
Externí odkaz:
https://doaj.org/article/84681ad62d1b40c89393fc3917165d7f
Autor:
Catherine M. Pichardo, Adaora Ezeani, Margaret S. Pichardo, Tanya Agurs‐Collins, Tiffany M. Powell‐Wiley, Brid Ryan, Tsion Zewdu Minas, Maeve Bailey‐Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Christopher A. Loffredo, Stefan Ambs
Publikováno v:
Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Background Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined th
Externí odkaz:
https://doaj.org/article/93de936fb0c243989fcdf89a6ac867ed
Autor:
Robert Y. S. Cheng, Lisa A. Ridnour, Adelaide L. Wink, Ana L. Gonzalez, Elise L. Femino, Helene Rittscher, Veena Somasundaram, William F. Heinz, Leandro Coutinho, M. Cristina Rangel, Elijah F. Edmondson, Donna Butcher, Robert J. Kinders, Xiaoxian Li, Stephen T. C. Wong, Daniel W. McVicar, Stephen K. Anderson, Milind Pore, Stephen M. Hewitt, Timothy R. Billiar, Sharon A. Glynn, Jenny C. Chang, Stephen J. Lockett, Stefan Ambs, David A. Wink
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)
Abstract A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TC
Externí odkaz:
https://doaj.org/article/5046eefbdac54f9198343a6b6f842146
Autor:
Yuuki Ohara, Wei Tang, Huaitian Liu, Shouhui Yang, Tiffany H. Dorsey, Helen Cawley, Paloma Moreno, Raj Chari, Mary R. Guest, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, Stefan Ambs, S. Perwez Hussain
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113434- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes contributing to the development of the basal-like/squamous subtype, known for its a
Externí odkaz:
https://doaj.org/article/de1d8a8b6bbd4daaa1ee9af22b193d83
Autor:
Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday, Anastasia Varvarigou, Antonios Chatzigeorgiou, Anders Nordström, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Jonathan D. Gilthorpe, Teresa Frisan
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic
Externí odkaz:
https://doaj.org/article/664873a7a747491ba70f6612076606eb
Autor:
Thomas J. Velenosi, Kristopher W. Krausz, Keisuke Hamada, Tiffany H. Dorsey, Stefan Ambs, Shogo Takahashi, Frank J. Gonzalez
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract Triple-negative breast cancer (TNBC) patients receive chemotherapy treatment, including doxorubicin, due to the lack of targeted therapies. Drug resistance is a major cause of treatment failure in TNBC and therefore, there is a need to ident
Externí odkaz:
https://doaj.org/article/25dda64b91734e499386bd331a57f043
Autor:
Tsion Zewdu Minas, Julián Candia, Tiffany H. Dorsey, Francine Baker, Wei Tang, Maeve Kiely, Cheryl J. Smith, Amy L. Zhang, Symone V. Jordan, Obadi M. Obadi, Anuoluwapo Ajao, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Frank J. Jenkins, Rick Kittles, Ann W. Hsing, Xin W. Wang, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here
Externí odkaz:
https://doaj.org/article/f21f5f4f98864f069e8d90ba4528ffb4
Autor:
Kuppusamy Balamurugan, Dipak K. Poria, Saadiya W. Sehareen, Savitri Krishnamurthy, Wei Tang, Lois McKennett, Veena Padmanaban, Kelli Czarra, Andrew J. Ewald, Naoto T. Ueno, Stefan Ambs, Shikha Sharan, Esta Sterneck
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Metastatic progression of epithelial cancers can be associated with epithelial-mesenchymal transition (EMT) including transcriptional inhibition of E-cadherin (CDH1) expression. Recently, EM plasticity (EMP) and E-cadherin–mediated, cluster-based m
Externí odkaz:
https://doaj.org/article/502009f78c0b40278ce52d20abc8b4b1