Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stefan, von Berg"'
Autor:
Roine I. Olsson, Rikard Pehrson, Rongfeng Chen, Jesper Malmberg, Anna Malmberg, Nafizal Hossain, Hanna Grindebacke, Mia Collins, Matti Lepistö, Yao Xiong, Nina Krutrök, Antonio Llinas, Thomas Hansson, Eva L. Hansson, Elisabeth Bäck, Anna Aagaard, Jane McPheat, Linda Thunberg, Sarah Lever, Agnes Leffler, Yafeng Xue, Stefan von Berg, Petter Svanberg, Frank Narjes, Marie Ramnegård, Glyn Hughes, Johan Jirholt
Publikováno v:
Journal of medicinal chemistry. 64(18)
Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. We have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5abd65b9c67744ef1cfe77ef55392ba
https://pubmed.ncbi.nlm.nih.gov/34464130
https://pubmed.ncbi.nlm.nih.gov/34464130
Autor:
Elke Ericson, Madelene Lindqvist, Ulf Gehrmann, Rajneesh Malhotra, Lena Ripa, Mei Ding, Johan Brengdahl, Stefan von Berg
Publikováno v:
ACS Chemical Biology. 14:543-553
Regulatory T (Treg) cells, expressing the transcription factor forkhead box p3 (FOXP3), are the key cells regulating peripheral autoreactive T lymphocytes by suppressing effector T cells. FOXP3+ Tr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044cf7a8366c5fde221b2d170b641f55
https://doi.org/10.1021/acschembio.9b00075
https://doi.org/10.1021/acschembio.9b00075
Autor:
Hanna Grindebacke, Frank Narjes, Eva L. Hansson, Yao Xiong, Antonio Llinas, Linda Thunberg, Jesper Malmberg, Stefan Tångefjord, Roine I. Olsson, Ge Hongbin, Rongfeng Chen, Yafeng Xue, Agnes Leffler, Hanna Leek, Thomas Hansson, Elisabeth Bäck, Jane McPheat, Nafizal Hossain, Matti Lepistö, Stefan von Berg, Johan Jirholt, Anna Aagaard
Publikováno v:
Journal of Medicinal Chemistry. 61:7796-7813
Retinoic acid receptor related orphan receptor γt (RORγt), has been identified as the master regulator of TH17-cell function and development, making it an attractive target for the treatment of autoimmune diseases by a small-molecule approach. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42539d4567cc086bb6e06886316ba550
https://doi.org/10.1021/acs.jmedchem.8b00783
https://doi.org/10.1021/acs.jmedchem.8b00783
Autor:
Stefan von Berg, Yafeng Xue, Mia Collins, Antonio Llinas, Roine I. Olsson, Torbjörn Halvarsson, Maria Lindskog, Jesper Malmberg, Johan Jirholt, Nina Krutrök, Marie Ramnegård, Marie Brännström, Anders Lundqvist, Matti Lepistö, Anna Aagaard, Jane McPheat, Eva L. Hansson, Rongfeng Chen, Yao Xiong, Thomas G. Hansson, Frank Narjes
Publikováno v:
ACS Med Chem Lett
[Image: see text] The further optimization of a recently disclosed series of inverse agonists of the nuclear receptor RORC2 is described. Investigations into the left-hand side of compound 1, guided by X-ray crystal structures, led to the substitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35560c4673291dc0889ef72ba74bdb91
https://pubmed.ncbi.nlm.nih.gov/31223457
https://pubmed.ncbi.nlm.nih.gov/31223457
Autor:
Rongfeng Chen, Hanna Grindebacke, Pia Hansson, Agnes Leffler, Yafeng Xue, Stefan von Berg, Roine I. Olsson, Hongbin Ge, Eva L. Hansson, Thomas Hansson, Jane McPheat, Johan Jirholt, Yao Xiong, Jenny Bernström, Frank Narjes, Anna Aagaard
Publikováno v:
ChemMedChem. 11:207-216
RORγt, an isoform of the retinoic acid-related orphan receptor gamma (RORc, RORγ), has been identified as the master regulator of T-helper 17 (TH 17) cell function and development, making it an attractive target for the treatment of autoimmune dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce9d845e8eb7130b18341e9259454b0
https://doi.org/10.1002/cmdc.201500432
https://doi.org/10.1002/cmdc.201500432
Autor:
Rebecka Klintenberg, Richard F. Cowburn, Biljana Georgievska, Kia Strömberg, Susanna Eketjäll, Michael Dabrowski, Per I. Arvidsson, Kristina Eliason, Fredrik Olsson, Karin Tunblad, Johanna Fälting, Ann-Cathrin Radesäter, Stefan von Berg
Publikováno v:
FEBS Journal. 282:65-73
A major hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ) peptides in amyloid plaques. Aβ peptides are produced by sequential cleavage of the amyloid precursor protein by the β amyloid cleaving enzyme (BACE) and the γ-secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9eef53c49172c7a7aec1d67ce17d7bc
https://doi.org/10.1111/febs.13103
https://doi.org/10.1111/febs.13103
Autor:
Johan Lundkvist, Biljana Georgievska, Stefan von Berg, Urban Lendahl, Susanne Gustavsson, Tjerk Bueters, Anders Juréus, Johanna Fälting, Samuel P.S. Svensson, Jan A.M. Neelissen, Susanna Eketjäll, Karin Agerman, Veronica Ramberg
Publikováno v:
Journal of Neurochemistry. 132:477-486
Aggregation of amyloid beta (Aβ) peptides and the subsequent neural plaque formation is a central aspect of Alzheimer's disease. Various strategies to reduce Aβ load in the brain are therefore intensely pursued. It has been hypothesized that reduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21da22bd7f9383f7c8df9f07ffec9f31
https://doi.org/10.1111/jnc.12937
https://doi.org/10.1111/jnc.12937
Autor:
Karin Kolmodin, Juliette Janson, Britt-Marie Swahn, Stefan von Berg, Tjerk Bueters, Gvido Cebers, Ann-Cathrine Radesäter, Johanna Fälting, Fredrik Jeppsson, Susanne Gustavsson, Bart Ploeger, Sofia Karlström, Susanna Eketjäll, Lise-Lotte Olsson
Publikováno v:
Journal of Biological Chemistry. 287:41245-41257
β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and formation of amyloid β peptide (Aβ) species. Because cerebral deposition of Aβ species might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be78180b718cc33322fedb5df5eba93
https://doi.org/10.1074/jbc.m112.409110
https://doi.org/10.1074/jbc.m112.409110
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 47:175-180
AR-A000002 is a novel and selective high-affinity 5-HT1B/1D receptor antagonist. The compound has been shown to enhance 5-HT turnover in the guinea pig brain in vivo and to increase the extracellular concentration of 5-HT and the metabolite 5-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1432a842b1691daf5aa403c930ddc653
https://doi.org/10.1002/jlcr.810
https://doi.org/10.1002/jlcr.810
Publikováno v:
Organometallics. 20:4312-4332
(E)-Configurated allylic ligands (S)-6a−f and (S)-8, bearing a leaving group at C(3) (allylic position) and an electron acceptor substituent at C(1), were synthesized from enantiopure (S)-ethyl lactate [(S)-1]. Complexation with Fe2(CO)9 (13) affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f415c1a9cefe28c34a8f7969ce2eb283
https://doi.org/10.1021/om010343l
https://doi.org/10.1021/om010343l