Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Stefan, Schoenfelder"'
Autor:
Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Larry Melidis, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement of other epigenomic
Externí odkaz:
https://doaj.org/article/64f8f18f52c349d5bcf820beb8d79a27
Autor:
Ioana Olan, Masami Ando-Kuri, Aled J. Parry, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser, Yasuyuki Ohkawa, Hiroshi Kimura, Masako Narita, Masashi Narita
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract HMGA1 is an abundant non-histone chromatin protein that has been implicated in embryonic development, cancer, and cellular senescence, but its specific role remains elusive. Here, we combine functional genomics approaches with graph theory t
Externí odkaz:
https://doaj.org/article/7476e4a7107d49bfbd49a2a4b2b12352
Autor:
Stephen Richer, Yuan Tian, Stefan Schoenfelder, Laurence Hurst, Adele Murrell, Giuseppina Pisignano
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-35 (2023)
Abstract Background There is widespread interest in the three-dimensional chromatin conformation of the genome and its impact on gene expression. However, these studies frequently do not consider parent-of-origin differences, such as genomic imprinti
Externí odkaz:
https://doaj.org/article/82621c9e5c664c34abfd6e15dd050f64
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Genome sequencing has revealed over 300 million genetic variations in human populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the remainder include short deletions or insertions, and small numbers of structural variants. H
Externí odkaz:
https://doaj.org/article/a1a0157e13b7444a9022c9b749de2d9a
Autor:
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromat
Externí odkaz:
https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
Autor:
Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne S. L. Chan, Guy St.C. Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith A. Samarajiwa, Peter Fraser, Masashi Narita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene
Externí odkaz:
https://doaj.org/article/cfcc6e6ce1f94a00978bd38e7e46977b
Autor:
Ian J Groves, Emma L A Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009875 (2021)
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered epigenetic changes at the int
Externí odkaz:
https://doaj.org/article/c2ebaa15d87542a8b9191e3a5a74e587
Autor:
Sebastian Kummer, Marko Hribernik, David M. Herold, Jasmin Mikl, Mario Dobrovnik, Stefan Schoenfelder
Publikováno v:
Transportation Research Interdisciplinary Perspectives, Vol 9, Iss , Pp 100278- (2021)
Current urban city logistics literature often claims that rising e-commerce and the associated courier-, express- and parcel- (CEP) deliveries are inherently responsible for the increase in urban road traffic and the related congestion, disturbances
Externí odkaz:
https://doaj.org/article/f4f974f776b34106a0e7f354c15bf572
Autor:
Gordana Wutz, Rene Ladurner, Brian Glenn St Hilaire, Roman R Stocsits, Kota Nagasaka, Benoit Pignard, Adrian Sanborn, Wen Tang, Csilla Várnai, Miroslav P Ivanov, Stefan Schoenfelder, Petra van der Lelij, Xingfan Huang, Gerhard Dürnberger, Elisabeth Roitinger, Karl Mechtler, Iain Finley Davidson, Peter Fraser, Erez Lieberman-Aiden, Jan-Michael Peters
Publikováno v:
eLife, Vol 9 (2020)
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin
Externí odkaz:
https://doaj.org/article/50f9b518193c4de2ba8e04afd984547d