Zobrazeno 1 - 10
of 1 113
pro vyhledávání: '"Stefan, M Pfister"'
Autor:
Shweta Godbole, Hannah Voß, Antonia Gocke, Simon Schlumbohm, Yannis Schumann, Bojia Peng, Martin Mynarek, Stefan Rutkowski, Matthias Dottermusch, Mario M. Dorostkar, Andrey Korshunov, Thomas Mair, Stefan M. Pfister, Marcel Kwiatkowski, Madlen Hotze, Philipp Neumann, Christian Hartmann, Joachim Weis, Friederike Liesche-Starnecker, Yudong Guan, Manuela Moritz, Bente Siebels, Nina Struve, Hartmut Schlüter, Ulrich Schüller, Christoph Krisp, Julia E. Neumann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically heterogenous. The application of omics technologies—mainly studying nucleic acids—has significantly improved MB classification and stratifica
Externí odkaz:
https://doaj.org/article/675fc26a61af443188a119d2062987c2
Autor:
Marc Zuckermann, Chen He, Jared Andrews, Aditi Bagchi, Roketa Sloan-Henry, Brandon Bianski, Jia Xie, Yingzhe Wang, Nathaniel Twarog, Arzu Onar-Thomas, Kati J. Ernst, Lei Yang, Yong Li, Xiaoyan Zhu, Jennifer K. Ocasio, Kaitlin M. Budd, James Dalton, Xiaoyu Li, Divyabharathi Chepyala, Junyuan Zhang, Ke Xu, Laura Hover, Jordan T. Roach, Kenneth Chun-Ho Chan, Nina Hofmann, Peter J. McKinnon, Stefan M. Pfister, Anang A. Shelat, Zoran Rankovic, Burgess B. Freeman, Jason Chiang, David T. W. Jones, Christopher L. Tinkle, Suzanne J. Baker
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant
Externí odkaz:
https://doaj.org/article/c4e30eaef7d54080a0db2c1628bcebbf
Autor:
Maria Otth, Katrin Scheinemann, Thankamma Ajithkumar, Kristian Aquilina, Shivaram Avula, Hoong-Wei Gan, Geert O. Janssens, Jurgen Lemiere, Giovanni Morana, Enrico Opocher, Stefan M. Pfister, Giorgio Porro, Felix Sahm, Ulrich-Wilhelm Thomale, Michelle van Egmond-Ebbeling, Hanneke M. van Santen, Barry Pizer, Stefan Rutkowski
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100166- (2024)
Tumours of the central nervous system (CNS) represent the most common group of solid tumours in children and adolescents up to the age of 18 years. They comprise several biological entities, subgroups, and subtypes. These subtypes and additional fact
Externí odkaz:
https://doaj.org/article/725bd3ec24ad47f99a354342f9261167
Autor:
David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T. W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorl
Externí odkaz:
https://doaj.org/article/73c7a67e39074505ad2f97eb63756762
Autor:
David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T. W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/47da4125f4844105ae9c15e274201e59
Autor:
David E. Reuss, Daniel Schrimpf, Asan Cherkezov, Abigail K. Suwala, Tereza Lausová, Matija Snuderl, David Capper, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling
Publikováno v:
Free Neuropathology, Vol 5 (2024)
The morphological patterns leading to the diagnosis of glioblastoma may also commonly be observed in several other distinct tumor entities, which can result in a mixed bag of tumors subsumed under this diagnosis. The 2021 WHO Classification of CNS Tu
Externí odkaz:
https://doaj.org/article/ec08a5df12b84342a99e3ace789f3936
Autor:
Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for pa
Externí odkaz:
https://doaj.org/article/55f18503cc5b446bb5969c8df01fb686
Autor:
Romain Sigaud, Thomas K. Albert, Caroline Hess, Thomas Hielscher, Nadine Winkler, Daniela Kocher, Carolin Walter, Daniel Münter, Florian Selt, Diren Usta, Jonas Ecker, Angela Brentrup, Martin Hasselblatt, Christian Thomas, Julian Varghese, David Capper, Ulrich W. Thomale, Pablo Hernáiz Driever, Michèle Simon, Svea Horn, Nina Annika Herz, Arend Koch, Felix Sahm, Stefan Hamelmann, Augusto Faria-Andrade, Nada Jabado, Martin U. Schuhmann, Antoinette Y. N. Schouten-van Meeteren, Eelco Hoving, Tilman Brummer, Cornelis M. van Tilburg, Stefan M. Pfister, Olaf Witt, David T. W. Jones, Kornelius Kerl, Till Milde
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors (MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify patients likely to benefit from MAPKi therapy. Here, we identi
Externí odkaz:
https://doaj.org/article/87e41da8f9f6492d937e992bb05c9817
Autor:
Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer, Janine Reunert, Barbara Fiedler, Ulrich Schüller, Thorsten Marquardt, Kornelius Kerl
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-4 (2023)
Abstract To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups—WNT, SHH, group 3 (G3) and group 4 (G4). However, there is li
Externí odkaz:
https://doaj.org/article/4d42ac6cc3f343f1a26382b1265c71a1
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract A founder variant is a genetic alteration, that is inherited from a common ancestor together with a surrounding chromosomal segment, and is observed at a high frequency in a defined population. This founder effect occurs as a consequence of
Externí odkaz:
https://doaj.org/article/2e8beb7a97cb49188a540fbbe49c3ea4