Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Stefan, Kehraus"'
Autor:
Tim Becker, Jan Heitkötter, Anna K. Krome, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Miriam Grosse, Birthe Sandargo, Ingo Stammberger, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 386 (2024)
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for or
Externí odkaz:
https://doaj.org/article/67c81d037ce842dc8ccd3f679297af6f
Autor:
Jan H. Voss, Max Crüsemann, Christian R.O. Bartling, Stefan Kehraus, Asuka Inoue, Gabriele M. König, Kristian Strømgaard, Christa E. Müller
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106492- (2023)
Summary: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, tritium-labeled YM and FR derivativ
Externí odkaz:
https://doaj.org/article/2a7281d6a7c5400a9b68ae13982ff5b1
Autor:
Cornelia Hermes, René Richarz, Daniel A. Wirtz, Julian Patt, Wiebke Hanke, Stefan Kehraus, Jan Hendrik Voß, Jim Küppers, Tsubasa Ohbayashi, Vigneshwaran Namasivayam, Judith Alenfelder, Asuka Inoue, Peter Mergaert, Michael Gütschow, Christa E. Müller, Evi Kostenis, Gabriele M. König, Max Crüsemann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
FR900359 (FR) is a Gq protein inhibitor depsipeptide isolated from an uncultivable plant endosymbiont and synthesized by non-ribosomal peptide synthetases. Here, the authors discover a cultivable bacterial FR producer and show that FrsA thioesterase
Externí odkaz:
https://doaj.org/article/2463819dc4b944af9d1f08c6cace66cc
Autor:
Cora Hertzer, Stefan Kehraus, Nils Böhringer, Fontje Kaligis, Robert Bara, Dirk Erpenbeck, Gert Wörheide, Till F. Schäberle, Heike Wägele, Gabriele M. König
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1596-1605 (2020)
Investigations on the biochemical relationship between Doriprismatica stellata (Chromodorididae, Doridoidea) nudibranchs, their egg ribbons, and the associated dietary sponge Spongia cf. agaricina (Demospongiae, Porifera) led to the isolation of the
Externí odkaz:
https://doaj.org/article/cd68ba7be878403191815957dc90020c
Autor:
Cora Hertzer, Nani Ingrid Jacquline Undap, Adelfia Papu, Dhaka Ram Bhandari, Stefan Aatz, Stefan Kehraus, Fontje Kaligis, Robert Bara, Till F. Schäberle, Heike Wägele, Gabriele M. König
Publikováno v:
Diversity, Vol 15, Iss 2, p 304 (2023)
Five Chromodoris species from North Sulawesi, Indonesia, were investigated for their sequestration of marine natural products. The cytotoxic 2-thiazolidinone macrolide latrunculin A (LatA) was the major metabolite in all examined Chromodoris species,
Externí odkaz:
https://doaj.org/article/311e9b5cea7c4d7c8d661618df594ec4
Autor:
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 57 (2022)
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., as
Externí odkaz:
https://doaj.org/article/ab51b259cd79400aa01e768efdd94017
Autor:
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. König, Anna K. Krome, Marc P. Hübner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 131 (2022)
Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths worldwide in 2019. Thus, there is an unmet medical need for novel and resistance-breaking anti-i
Externí odkaz:
https://doaj.org/article/edb4852a2b3245799a4221b686948f81
Autor:
Benjamin Libor, Henrik Harms, Stefan Kehraus, Ekaterina Egereva, Max Crüsemann, Gabriele M. König
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2191-2203 (2019)
Fungi are an important source of bioactive metabolites. The Fungal one-step IsolatioN Device (FIND) technology allows the isolation of rare fungi from terrestrial and marine samples. The FIND comprises a multi-chambered micro agar plate, where initia
Externí odkaz:
https://doaj.org/article/027fbf07503b4836ac97030075d8c6a3
Autor:
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluatio
Externí odkaz:
https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b
Autor:
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 920 (2022)
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S. aureus using fluctuat
Externí odkaz:
https://doaj.org/article/f755728120db4450ac61d370364e0082