Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefan, Kavanagh"'
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7b92fc3cedccfdd23559470f0ac18
https://doi.org/10.1021/acsmedchemlett.1c00216
https://doi.org/10.1021/acsmedchemlett.1c00216
Autor:
Paul, McGillan, Neil G, Berry, Gemma L, Nixon, Suet C, Leung, Peter J H, Webborn, Mark C, Wenlock, Stefan, Kavanagh, Andrew, Cassidy, Rachel H, Clare, Darren A, Cook, Kelly L, Johnston, Louise, Ford, Stephen A, Ward, Mark J, Taylor, W David, Hong, Paul M, O'Neill
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::263d745f9f3d148738e23c20f3fefc76
https://pubmed.ncbi.nlm.nih.gov/34527179
https://pubmed.ncbi.nlm.nih.gov/34527179
Autor:
Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo
Publikováno v:
Journal of medicinal chemistry. 63(23)
Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER+ breast cancer. Structure based design together with systematic investigation of each region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a07ad198923d95942c131a39083de
https://pubmed.ncbi.nlm.nih.gov/32910656
https://pubmed.ncbi.nlm.nih.gov/32910656
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a67afcb9d9f3a9d55bf8c9a97e46c9a1
https://pubmed.ncbi.nlm.nih.gov/30617067
https://pubmed.ncbi.nlm.nih.gov/30617067
Autor:
Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
Publikováno v:
MedChemComm. 7:1022-1032
The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9536266d79924c4362a14dae6582a0
https://doi.org/10.1039/c5md00589b
https://doi.org/10.1039/c5md00589b
Autor:
Stefan Kavanagh, Julian A. Hudson, David S. Clarke, Alison Easter, Paul Schofield, Anne Ertan, Darren Mckerrecher, Hayley S. Brown, Suzanne S. Bowker, James S. Scott, Elizabeth A. Martin, David Laber, Philip A. MacFaul, Per H. Svensson, Joanne Teague, Andrew G. Leach, Kristin Goldberg, Katy J. Brocklehurst
Publikováno v:
Journal of Medicinal Chemistry. 57:8984-8998
Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment of type II diabetes and other elements of metabolic syndrome. During progression of a previously disclosed candidate 1 through mice toxicity studies, we observed tonic-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b741924ba4d25d89fbb217e9b9132a04
https://doi.org/10.1021/jm5011012
https://doi.org/10.1021/jm5011012
Publikováno v:
Toxicology Letters. 295:S250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1ff7441f10d9fc2129875c6f6b68d1
https://doi.org/10.1016/j.toxlet.2018.06.1026
https://doi.org/10.1016/j.toxlet.2018.06.1026
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039caecc0852bb3bd72abf0265b59ccf
https://doi.org/10.1038/ncomms7715
https://doi.org/10.1038/ncomms7715