Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Stefan, Jentsch"'
Autor:
Matías Capella, Imke K. Mandemaker, Lucía Martín Caballero, Fabian den Brave, Boris Pfander, Andreas G. Ladurner, Stefan Jentsch, Sigurd Braun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering
Externí odkaz:
https://doaj.org/article/7c25cbe4fae14af59e6291014ce9f3bc
Autor:
Fabian den Brave, Lucas V. Cairo, Chandhuru Jagadeesan, Carmen Ruger-Herreros, Axel Mogk, Bernd Bukau, Stefan Jentsch
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the absence of the autophagic machinery, nuclear protein aggrega
Externí odkaz:
https://doaj.org/article/1bce3ea995b94ff6894220e79aaecc63
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1294-1303 (2017)
The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand b
Externí odkaz:
https://doaj.org/article/6e382995778d47c2b6f68def3ce672f9
Autor:
Sigurd Braun, Boris Pfander, Imke K Mandemaker, Andreas G. Ladurner, Matías Capella, Fabian den Brave, Lucía Martín Caballero, Stefan Jentsch
Ribosomal RNA genes (rDNA) are highly unstable and susceptible to rearrangement due to active transcription and their repetitive nature. Compartmentalization of rDNA in the nucleolus suppresses uncontrolled recombination. However, broken repeats must
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b5e90d286ff7a1b3fb64aeac991bdd5
https://doi.org/10.1101/2021.01.05.425376
https://doi.org/10.1101/2021.01.05.425376
Misassembled nuclear pore complexes (NPCs) are removed by sealing off the surrounding nuclear envelope (NE), which is mediated by members of the ESCRT (endosomal sorting complexes required for transport) machinery. Recruitment of ESCRT proteins to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f82aeb39f303260e08b787777044e7
https://doi.org/10.1101/2020.06.25.171694
https://doi.org/10.1101/2020.06.25.171694
Publikováno v:
Journal of cell science. 133(24)
Misassembled nuclear pore complexes (NPCs) are removed by sealing off the surrounding nuclear envelope (NE), which is conducted by the endosomal sorting complexes required for transport (ESCRT) machinery. Recruitment of ESCRT proteins to the NE is me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91c16b1969d1eb3bfeb6711b21c9aa73
https://pubmed.ncbi.nlm.nih.gov/33262311
https://pubmed.ncbi.nlm.nih.gov/33262311
Autor:
Lucas V. Cairo, Carmen Ruger-Herreros, Axel Mogk, Stefan Jentsch, Bernd Bukau, Fabian den Brave, Chandhuru Jagadeesan
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 9, Pp-(2020)
CELL REPORTS
Cell Reports, Vol 31, Iss 9, Pp-(2020)
CELL REPORTS
Summary The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the absence of the autophagic machinery, nuclear protein aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc90f3b38e8a50304ed2b633e182a5b
http://europepmc.org/articles/PMC7273177
http://europepmc.org/articles/PMC7273177
Autor:
Stefan Jentsch, Boris Pfander, Chia-Wei Lee, Philipp Erdmann, Florian Wilfling, Wolfgang Baumeister, Yumei Zheng, Brenda A. Schulman
Publikováno v:
SSRN Electronic Journal.
SummaryAutophagy eliminates cytoplasmic content selected by autophagy receptors, which link cargoes to the membrane bound autophagosomal ubiquitin-like protein Atg8/LC3. Here, we discover a selective autophagy pathway for protein condensates formed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623914c31822b10b438257ba61de56e6
https://doi.org/10.2139/ssrn.3624433
https://doi.org/10.2139/ssrn.3624433
Autor:
Hiroshi Arakawa, George-Lucian Moldovan, Huseyin Saribasak, Nesibe Nur Saribasak, Stefan Jentsch, Jean-Marie Buerstedde
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e366 (2006)
Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replica
Externí odkaz:
https://doaj.org/article/06721dd8b6824b728333a91a571b999a
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
SCIENTIFIC REPORTS
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
SCIENTIFIC REPORTS
RNA polymerase II (RNAPII) is the workhorse of eukaryotic transcription and produces messenger RNAs and small nuclear RNAs. Stalling of RNAPII caused by transcription obstacles such as DNA damage threatens functional gene expression and is linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4025c19063ea9d42eef75d275aec419d
http://europepmc.org/articles/PMC6884465
http://europepmc.org/articles/PMC6884465