Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stefan, Hannus"'
Autor:
Akito Koike, Frank Becker, Peter Sennhenn, Jason Kim, Jenny Zhang, Stefan Hannus, Klaus Brehm
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010483 (2022)
BackgroundThe potentially lethal zoonosis alveolar echinococcosis (AE) is caused by the metacestode larval stage of the tapeworm Echinococcus multilocularis. Current AE treatment options are limited and rely on surgery as well as on chemotherapy invo
Externí odkaz:
https://doaj.org/article/bef4cc4caf2d414cabb863e7acf5e848
Autor:
Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 757 (2021)
Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pe
Externí odkaz:
https://doaj.org/article/5aa87a5ca06b4543a7a20fec80386a82
Autor:
Markus Hutterer, Karin Menhart, Hans-Jürgen Wester, Xin Lu, Dirk Hellwig, Bernhard Polzer, Peter Hau, Jirka Grosse, Daniel Heudobler, Benedikt Pregler, Michaela Bayerlová, Markus J. Riemenschneider, Stefan Hannus, Tim Beißbarth, Tobias Pukrop, Annalen Bleckmann, Saskia Kropf, Jutta Moosbauer, Raquel Blazquez, Florian Lüke, Rezan Fahrioglu Yamaci, Christoph Klein
Publikováno v:
Oncotarget. 9:18844-18857
Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146338f4107dbee1295d36cf05e6c93d
https://doi.org/10.18632/oncotarget.24787
https://doi.org/10.18632/oncotarget.24787
Autor:
Margaret S. Lee, Sharon Shacham, Marsha Crochiere, Frank Becker, Erkan Baloglu, Michael Kauffman, Kerrin Hansen, Stefan Hannus, Yosef Landesman
Publikováno v:
Oncotarget
XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20c36cb8ee7c00a27663ab673a5806
https://doi.org/10.18632/oncotarget.22801
https://doi.org/10.18632/oncotarget.22801
Autor:
Mathias Stotz, Ludwig Wankerl, Gunter Meister, Stefan Hannus, Alexander Gust, Kevin Kramm, Dina Grohmann, Thomas Treiber, Kerrin Hansen, Leonhard Jakob, Franz Herzog, Nora Treiber
Publikováno v:
RNA. 22:383-396
In the microRNA (miRNA) pathway, Dicer processes precursors to mature miRNAs. For efficient processing, double-stranded RNA-binding proteins support Dicer proteins. In flies, Loquacious (Loqs) interacts with Dicer1 (dmDcr1) to facilitate miRNA proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9a41005701ffaa04c36d1c8510f227
https://doi.org/10.1261/rna.055426.115
https://doi.org/10.1261/rna.055426.115
Autor:
Michaela Beitzinger, Stefan Hannus, Stefan Berg, Bettina Ziegelmann, Peter Rosenkranz, Elisabeth Abele
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Honey bees are increasingly important in the pollination of crops and wild plants. Recent reports of the weakening and periodical high losses of managed honey bee colonies have alarmed beekeeper, farmers and scientists. Infestations with the ectopara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faca0592902449d8e83334d65402700
http://europepmc.org/articles/PMC5766531
http://europepmc.org/articles/PMC5766531
Autor:
Florian, Lüke, Raquel, Blazquez, Rezan Fahrioglu, Yamaci, Xin, Lu, Benedikt, Pregler, Stefan, Hannus, Karin, Menhart, Dirk, Hellwig, Hans-Jürgen, Wester, Saskia, Kropf, Daniel, Heudobler, Jirka, Grosse, Jutta, Moosbauer, Markus, Hutterer, Peter, Hau, Markus J, Riemenschneider, Michaela, Bayerlová, Annalen, Bleckmann, Bernhard, Polzer, Tim, Beißbarth, Christoph A, Klein, Tobias, Pukrop
Publikováno v:
Oncotarget
Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8eff885861e87552e1b45e13ba150409
https://pubmed.ncbi.nlm.nih.gov/29721166
https://pubmed.ncbi.nlm.nih.gov/29721166
Autor:
Stefan Berg, Michaela Beitzinger, Elisabeth Abele, Peter Rosenkranz, Bettina Ziegelmann, Stefan Hannus
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297b38129a72ba859b51d6673f2a5134
http://link.springer.com/article/10.1038/s41598-018-21311-2
http://link.springer.com/article/10.1038/s41598-018-21311-2
Autor:
Stefan Hannus, Roland Brock, Heike Glauner, Kerrin Hansen, Frank Becker, Yi-Da Chung, Ben Steemers, Ivo R. Ruttekolk
Publikováno v:
British Journal of Pharmacology. 160:958-970
Background and purpose: In vitro assays that determine activities of drug candidates with isolated targets have only limited predictive value for activities in cellular assays. Poor membrane permeability and off-target binding are major reasons for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5831e9d9db5726809f168caa404ce0
https://doi.org/10.1111/j.1476-5381.2010.00732.x
https://doi.org/10.1111/j.1476-5381.2010.00732.x
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-B09
The quantification of Target Occupancy (TO) in cells after application of an inhibitor is an important parameter to correlate the biochemical features of a drug with its in vivo efficacy. Experimental evidence of TO is a robust support of the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65dbc488d494a3b909d7a3f52a95b4e1
https://doi.org/10.1158/1535-7163.targ-17-lb-b09
https://doi.org/10.1158/1535-7163.targ-17-lb-b09