Výsledky vyhledávání - "Stefan, Hamm"

Akademický článek

Preclinical Safety Assessment of the EBS-LASV Vaccine Candidate against Lassa Fever Virus

Autor: Demetrius Matassov, Lisa Evans DeWald, Stefan Hamm, Rebecca M. Nowak, Cheryl S. Gerardi, Theresa E. Latham, Rong Xu, Amara Luckay, Tracy Chen, Marc Tremblay, Jeffry Shearer, Melissa Wynn, John H. Eldridge, Kelly Warfield, Kevin Spurgers

Publikováno v: Vaccines, Vol 12, Iss 8, p 858 (2024)

There are currently no prophylactic vaccines licensed to protect against Lassa fever caused by Lassa virus (LASV) infection. The Emergent BioSolutions (EBS) vaccine candidate, EBS-LASV, is being developed for the prevention of Lassa fever. EBS-LASV i

Externí odkaz: https://doaj.org/article/5ac6e9310ddd44a58999bee90fd7b27a

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Akademický článek

Preclinical Development of Oncolytic Immunovirotherapy for Treatment of HPVPOS Cancers

Autor: Lukkana Suksanpaisan, Rong Xu, Mulu Z. Tesfay, Carolyn Bomidi, Stefan Hamm, Rianna Vandergaast, Nathan Jenks, Michael B. Steele, Ayuko Ota-Setlik, Hinna Akhtar, Amara Luckay, Rebecca Nowak, Kah Whye Peng, John H. Eldridge, David K. Clarke, Stephen J. Russell, Rosa Maria Diaz

Publikováno v: Molecular Therapy: Oncolytics, Vol 10, Iss , Pp 1-13 (2018)

Immunotherapy for HPVPOS malignancies is attractive because well-defined, viral, non-self tumor antigens exist as targets. Several approaches to vaccinate therapeutically against HPV E6 and E7 antigens have been adopted, including viral platforms suc

Externí odkaz: https://doaj.org/article/3396dace4a2548be8e2c17cb86f01e32

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Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Publikováno v: Journal of Clinical Investigation. 130:539-551

Recent occurrences of filoviruses and the arenavirus Lassa virus (LASV) in overlapping endemic areas of Africa highlight the need for a prophylactic vaccine that would confer protection against all of these viruses that cause lethal hemorrhagic fever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff5e32f0f3faea9c6d40d076939d119
https://doi.org/10.1172/jci131958

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A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for a soluble glycoprotein vaccine to prevent disease caused by Nipah or Hendra viruses

Autor: Marc Gurwith, Antony S. Dimitrov, Susan Sciotto-Brown, Stefan Hamm, Robert T. Chen, Emily R. Smith, Rong Xu, Luz Hermida, Tracy Chen, Marc Tremblay, Michael A. Egan, John H. Eldridge, Demetrius Matassov

Publikováno v: Vaccine. 39(38)

Auro Vaccines LLC has developed a protein vaccine to prevent disease from Nipah and Hendra virus infection that employs a recombinant soluble Hendra glycoprotein (HeV-sG) adjuvanted with aluminum phosphate. This vaccine is currently under clinical ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ecdc6cfe2be6345c231309d54bd8de
https://pubmed.ncbi.nlm.nih.gov/34373117

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Recombinant Isfahan Virus and Vesicular Stomatitis Virus Vaccine Vectors Provide Durable, Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge

Autor: Stefan Hamm, Theresa E. Latham, David K. Clarke, John H. Eldridge, Scott C. Weaver, Robert L. Seymour, Grace Leal, Demetrius Matassov, Rebecca M. Nowak, Farooq Nasar, Robert B. Tesh, Rodion Gorchakov

Publikováno v: Journal of Virology

The demonstrated clinical efficacy of a recombinant vesicular stomatitis virus (rVSV) vaccine vector has stimulated the investigation of additional serologically distinct Vesiculovirus vectors as therapeutic and/or prophylactic vaccine vectors to com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4702a44ace3cbaf06fed9f02a06739ba
https://europepmc.org/articles/PMC5375677/

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Corrigendum to 'Phenotypic properties resulting from directed gene segment reassortment between wild-type A/Sydney/5/97 influenza virus and the live attenuated vaccine strain' [Virology 367 (2007) 275–287]

Autor: Gail A. D'Arco, Robert E. O'Neill, Heather Arendt, Adriana Cahill, Theresa E. Latham, Gabriele Neumann, Christopher L. Parks, Jennifer Obregon, Timothy J. Zamb, Joanne DeStefano, Thomas M. Bechert, Deborah A. Buonagurio, Mohinderjit S. Sidhu, Stephen A. Udem, Leonid Shutyak, Christopher J. Passarotti, Stefan Hamm

Publikováno v: Virology. 374(2):535-539

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47900d96d7b4e0f2660d3f77b0fc1798

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Phenotypic properties resulting from directed gene segment reassortment between wild-type A/Sydney/5/97 influenza virus and the live attenuated vaccine strain

Autor: Deborah A. Buonagurio, Stefan Hamm, Leonid Shutyak, Joanne DeStefano, Stephen A. Udem, Gail A. D'Arco, Christopher L. Parks, Thomas M. Bechert, Christopher J. Passarotti, Mohinderjit S. Sidhu, Adriana Cahill, Theresa E. Latham, Timothy J. Zamb, Robert E. O'Neill, Gabriele Neumann, Heather Arendt, Jennifer Obregon

Publikováno v: Virology. 367:275-287

Widespread use of a live-attenuated influenza vaccine (LAIV) in the United States (licensed as FluMist) raises the possibility that vaccine viruses will contribute gene segments to the type A influenza virus gene pool. Progeny viruses possessing new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d754f06807917e9357c16627d6fd52ff
https://doi.org/10.1016/j.virol.2007.05.004

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Vaccination With a Highly Attenuated Recombinant Vesicular Stomatitis Virus Vector Protects Against Challenge With a Lethal Dose of Ebola Virus

Autor: Ayuko Ota-Setlik, Andrea Marzi, John H. Eldridge, Demetrius Matassov, Heinz Feldmann, Michael A. Egan, Friederike Feldmann, Stefan Hamm, Joan B. Geisbert, Becky Nowak, Terri Latham, David K. Clarke, Rong Xu, Thomas W. Geisbert, Chad E. Mire

Publikováno v: Journal of Infectious Diseases

Previously, recombinant vesicular stomatitis virus (rVSV) pseudotypes expressing Ebolavirus glycoproteins (GPs) in place of the VSV G protein demonstrated protection of nonhuman primates from lethal homologous Ebolavirus challenge. Those pseudotype v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480c861cf27b1a31eb9d1bcaa74c8e4f
https://pubmed.ncbi.nlm.nih.gov/26109675

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The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA

Autor: Moshe Szyf, J. David Knox, Nancy Detich, George Just, Stefan Hamm

Publikováno v: Journal of Biological Chemistry. 278:20812-20820

S-Adenosylmethionine (AdoMet) is the methyl donor of numerous methylation reactions. The current model is that an increased concentration of AdoMet stimulates DNA methyltransferase reactions, triggering hypermethylation and protecting the genome agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3fc146a726a5ef6c0de2bf9cd3ed70d
https://doi.org/10.1074/jbc.m211813200

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