Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Stefan, Hüttelmaier"'
Autor:
Sven Hagemann, Danny Misiak, Jessica L. Bell, Tommy Fuchs, Marcell I. Lederer, Nadine Bley, Monika Hämmerle, Ehab Ghazy, Wolfgang Sippl, Johannes H. Schulte, Stefan Hüttelmaier
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)
Abstract Background Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strateg
Externí odkaz:
https://doaj.org/article/ca683df65b6941eab6938839b5d6ab26
Autor:
Ulrike Zinnall, Miha Milek, Igor Minia, Carlos H. Vieira-Vieira, Simon Müller, Guido Mastrobuoni, Orsalia-Georgia Hazapis, Simone Del Giudice, David Schwefel, Nadine Bley, Franka Voigt, Jeffrey A. Chao, Stefan Kempa, Stefan Hüttelmaier, Matthias Selbach, Markus Landthaler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.
Externí odkaz:
https://doaj.org/article/540eabd8ef794660a1b89d9588fee403
Autor:
Dirk Tänzler, Marc Kipping, Marcell Lederer, Wiebke F Günther, Christian Arlt, Stefan Hüttelmaier, Andreas Merkenschlager, Andrea Sinz
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282593 (2023)
We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5 (ADCY5)-overexpressing cell lines. A comparison of cAMP levels was performed for ADCY5 wild-type and R418W mutan
Externí odkaz:
https://doaj.org/article/d16a4df4aa604f6ba62636605f082237
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/fa3ce391f1f44f98982d03725da51593
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumor
Externí odkaz:
https://doaj.org/article/2fab5abc84ca4a3daabdfded742fbe0b
Autor:
Markus Glaß, Stefan Hüttelmaier
Publikováno v:
Viruses, Vol 15, Iss 7, p 1431 (2023)
The oncofetal RNA-binding protein IGF2BP1 has been reported to be a driver of tumor progression in a multitude of cancer entities. Its main function is the stabilization of target transcripts by shielding these from miRNA-mediated degradation. Howeve
Externí odkaz:
https://doaj.org/article/a2211a040a6348fe9a8683dd1a7fc0cb
Autor:
Matthew Wong, Yuting Sun, Zhichao Xi, Giorgio Milazzo, Rebecca C. Poulos, Christoph Bartenhagen, Jessica L. Bell, Chelsea Mayoh, Nicholas Ho, Andrew E. Tee, Xiaoqiong Chen, Yang Li, Roberto Ciaccio, Pei Y. Liu, Chen C. Jiang, Qing Lan, Nisitha Jayatilleke, Belamy B. Cheung, Michelle Haber, Murray D. Norris, Xu D. Zhang, Glenn M. Marshall, Jenny Y. Wang, Stefan Hüttelmaier, Matthias Fischer, Jason W. H. Wong, Hongxi Xu, Giovanni Perini, Qihan Dong, Rani E. George, Tao Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorige
Externí odkaz:
https://doaj.org/article/a673d07528164588b51a22500785ed47
Autor:
Tim Schneider, Lee-Hsueh Hung, Masood Aziz, Anna Wilmen, Stephanie Thaum, Jacqueline Wagner, Robert Janowski, Simon Müller, Silke Schreiner, Peter Friedhoff, Stefan Hüttelmaier, Dierk Niessing, Michael Sattler, Andreas Schlundt, Albrecht Bindereif
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis
Externí odkaz:
https://doaj.org/article/cc6cce93f90546a49171482eb793687f
Autor:
Danny Misiak, Sven Hagemann, Jessica L. Bell, Bianca Busch, Marcell Lederer, Nadine Bley, Johannes H. Schulte, Stefan Hüttelmaier
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
MYCN gene amplification and upregulated expression are major hallmarks in the progression of high-risk neuroblastoma. MYCN expression and function in modulating gene synthesis in neuroblastoma is controlled at virtually every level, including poorly
Externí odkaz:
https://doaj.org/article/9e16d521f31e40e880ef13446d59b3db
Autor:
Markus Glaß, Danny Misiak, Nadine Bley, Simon Müller, Sven Hagemann, Bianca Busch, Alexander Rausch, Stefan Hüttelmaier
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) promotes tumor progression in a variety of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs enco
Externí odkaz:
https://doaj.org/article/17426e720dde440d8583b4cf2a497a13