Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Stefan, Dröse"'
Autor:
Andreas Trojan, Christian Kühne, Michael Kiessling, Johannes Schumacher, Stefan Dröse, Christian Singer, Christian Jackisch, Christoph Thomssen, Gerd A Kullak-Ublick
Publikováno v:
JMIR Formative Research, Vol 8, p e55917 (2024)
BackgroundThe evaluation of electronic patient-reported outcomes (ePROs) is increasingly being used in clinical studies of patients with cancer and enables structured and standardized data collection in patients’ everyday lives. So far, few studies
Externí odkaz:
https://doaj.org/article/869aa6dfcdec43b9ab44d038d3dac136
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 176-191 (2017)
Cyclic GMP-dependent protein kinase 1 (PKG1) mediates presynaptic nociceptive long-term potentiation (LTP) in the spinal cord and contributes to inflammatory pain in rodents but the present study revealed opposite effects in the context of neuropathi
Externí odkaz:
https://doaj.org/article/cefce92198ae42588e311dc9d7b04951
Autor:
Markus Müller, Kai Zacharowski, Sarah Kübel, Stefan Dröse, Elisabeth H Adam, Stephanie Böhmert, Dania Fischer, Christian F Weber
Publikováno v:
Transfusion. 61:1258-1265
BACKGROUND Conditions during blood product storage and transportation should maintain quality. The aim of this in vitro study was to investigate the effect of interruption of agitation, temporary cooling (TC), and pneumatic tube system transportation
Autor:
Hans-Hermann Hoepken, Suzana Gispert, Blas Morales, Oliver Wingerter, Domenico Del Turco, Alexander Mülsch, Robert L. Nussbaum, Klaus Müller, Stefan Dröse, Ulrich Brandt, Thomas Deller, Brunhilde Wirth, Alexei P. Kudin, Wolfram S. Kunz, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 2, Pp 401-411 (2007)
Oxidative stress and protein aggregation are biochemical hallmarks of Parkinson’s disease (PD), a frequent sporadic late-onset degenerative disorder particularly of dopaminergic neurons in the substantia nigra, resulting in impaired spontaneous mov
Externí odkaz:
https://doaj.org/article/13394e1023644fa291cb79c68e130fa8
Autor:
Dajana Parganlija, Michael Klinkenberg, Jorge Domínguez-Bautista, Miriam Hetzel, Suzana Gispert, Marthe A Chimi, Stefan Dröse, Sören Mai, Ulrich Brandt, Georg Auburger, Marina Jendrach
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95288 (2014)
The mitochondrial kinase PINK1 and the ubiquitin ligase Parkin are participating in quality control after CCCP- or ROS-induced mitochondrial damage, and their dysfunction is associated with the development and progression of Parkinson's disease. Furt
Externí odkaz:
https://doaj.org/article/2babc727b13d4a70af9e4685b395312f
Autor:
Bernhard Brüne, Dominik C. Fuhrmann, Stefan Dröse, Ilka Wittig, Tobias Schmid, Nathalie Dehne
Publikováno v:
Cellular and Molecular Life Sciences. 75:3051-3067
Cell stress such as hypoxia elicits adaptive responses, also on the level of mitochondria, and in part is mediated by the hypoxia-inducible factor (HIF) 1α. Adaptation of mitochondria towards acute hypoxic conditions is reasonably well understood, w
Autor:
Stefan Dröse, Stephanie Krack, Lucie Sokolova, Klaus Zwicker, Hans-Dieter Barth, Nina Morgner, Heinrich Heide, Mirco Steger, Esther Nübel, Volker Zickermann, Stefan Kerscher, Bernhard Brutschy, Michael Radermacher, Ulrich Brandt
Publikováno v:
PLoS Biology, Vol 9, Iss 8, p e1001128 (2011)
Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in com
Externí odkaz:
https://doaj.org/article/0c7b2c6cd91b4b7aa58153adf4b3d4a5
Publikováno v:
MedChemComm. 8:657-661
By probing the quinone substrate binding site of mitochondrial complex I with a focused set of quinazoline-based compounds, we identified substitution patterns as being critical for the observed inhibition. The structure activity relationship study a
Autor:
Simone Fulda, Lara Kleinesudeik, Stefan Dröse, Katharina Rohde, Katrin Schröder, Juliana Heidler, Stefanie Roesler, Oliver Löwe, Ilka Wittig
Publikováno v:
Cell Death & Differentiation. 24:83-97
Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a
Publikováno v:
Free Radical Biology and Medicine. 99:43-53
Manganese-induced toxicity has been linked to mitochondrial dysfunction and an increased generation of reactive oxygen species (ROS). We could recently show in mechanistic studies that Mn2+ ions induce hydrogen peroxide (H2O2) production from the ubi