Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Stefan, Canzar"'
Publikováno v:
Algorithms for Molecular Biology, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Metric multidimensional scaling is one of the classical methods for embedding data into low-dimensional Euclidean space. It creates the low-dimensional embedding by approximately preserving the pairwise distances between the input points. Ho
Externí odkaz:
https://doaj.org/article/1cd6811517a8445d81e32bd86545987e
Autor:
Van Hoan Do, Stefan Canzar
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Emerging single-cell technologies profile multiple types of molecules within individual cells. A fundamental step in the analysis of the produced high-dimensional data is their visualization using dimensionality reduction techniques such as
Externí odkaz:
https://doaj.org/article/2a2b62b8572a4eb2953fc10359f62288
Autor:
Theresa Kaeuferle, Tanja A Stief, Stefan Canzar, Nayad N Kutlu, Semjon Willier, Dana Stenger, Paulina Ferrada‐Ernst, Nicola Habjan, Annika E Peters, Dirk H Busch, Tobias Feuchtinger
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract Objectives Exploiting the forces of human T cells for treatment has led to the current paradigm of emerging immunotherapy strategies. Genetic engineering of the T‐cell receptor (TCR) redirects specificity, ablates alloreactivity and brings
Externí odkaz:
https://doaj.org/article/ab8c3e6d149d403c8001e8a0cca41eae
Autor:
Florian Hoss, James L. Mueller, Francisca Rojas Ringeling, Juan F. Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D. Putnam, Richard D. Kolodner, Stefan Canzar, Matthias Geyer, Hal M. Hoffman, Eicke Latz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 is
Externí odkaz:
https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec
Autor:
Natalia M. Gonzales, Jungkyun Seo, Ana I. Hernandez Cordero, Celine L. St. Pierre, Jennifer S. Gregory, Margaret G. Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A. Palmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis. Here, the authors analyze 1,063 LG x SM AIL mice to identify significant associations for 50 traits
Externí odkaz:
https://doaj.org/article/b9f3f59ed9014b36ad09966559d40fb1
Autor:
Valina L. Dawson, Guo Li Ming, Kimberly M. Christian, Stephanie J. Temme, Weidong Li, Stephen M. Eacker, Kuei Sen Hsu, Stefan Canzar, Ki Jun Yoon, Francisca Rojas Ringeling, Ted M. Dawson, Ha Nam Nguyen, Bo Xiao, Paul F. Worley, Yu Ting Lin, Namshik Kim, Hongjun Song, Ying Zhou
Publikováno v:
Biological Psychiatry. 92:815-826
Background Gene dosage imbalance caused by copy number variations (CNVs) is a prominent contributor to brain disorders. In particular, 15q11.2 CNV duplications and deletions have been associated with autism spectrum disorder and schizophrenia, respec
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101126- (2020)
Summary: The massive size of single-cell RNA sequencing datasets often exceeds the capability of current computational analysis methods to solve routine tasks such as detection of cell types. Recently, geometric sketching was introduced as an alterna
Externí odkaz:
https://doaj.org/article/b43c4b9ada704f55958ff8bc20008f72
Autor:
Taku Ito-Kureha, Cristina Leoni, Kayla Borland, Giulia Cantini, Marian Bataclan, Rebecca N. Metzger, Gregor Ammann, Anne B. Krug, Annalisa Marsico, Stefanie Kaiser, Stefan Canzar, Stefan Feske, Silvia Monticelli, Julian König, Vigo Heissmeyer
Publikováno v:
Nat. Immunol. 23, 1208-1221 (2022)
T cell antigen-receptor (TCR) signaling controls the development, activation and survival of T cells by involving several layers and numerous mechanisms of gene regulation. N6-methyladenosine (m6A) is the most prevalent messenger RNA modification aff
Autor:
Jianfeng Sun, Martin Philpott, Danson Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown Sr, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Unique Molecular Identifiers (UMIs) are random oligonucleotide sequences that remove PCR amplification biases. However, the impact that PCR associated sequencing errors have on the accuracy of generating absolute counts of RNA molecules is underappre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c69b4cdeab4c99eeed128340225ded
https://doi.org/10.1101/2023.04.06.535911
https://doi.org/10.1101/2023.04.06.535911
Publikováno v:
2022 45th Jubilee International Convention on Information, Communication and Electronic Technology (MIPRO).