Utilizing an Ex Vivo Skin Penetration Analysis Model for Predicting Ocular Drug Penetration: A Feasibility Study with Curcumin Formulations

Autor: Christian Raab, Stefan Brugger, Jara-Sophie Lechner, Geisa Nascimento Barbalho, Taís Gratieri, Priyanka Agarwal, Ilva D. Rupenthal, Cornelia M. Keck

Publikováno v: Pharmaceutics, Vol 16, Iss 10, p 1302 (2024)

Objective: This study aimed to investigate the feasibility of using the digital image processing technique, developed to semi-quantitatively study dermal penetration, to study corneal penetration in an ex vivo porcine eye model. Here, we investigated

Externí odkaz: https://doaj.org/article/5c53097509c547ed92a8326f193836e6

Associations of Serum Dickkopf‐1 and Sclerostin With Cardiovascular Events: Results From the Prospective Bruneck Study

Autor: Gerhard Klingenschmid, Lena Tschiderer, Gottfried Himmler, Gregorio Rungger, Stefan Brugger, Peter Santer, Johann Willeit, Stefan Kiechl, Peter Willeit

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 6 (2020)

Background Dickkopf‐1 and sclerostin have been implicated in atherosclerosis and vascular calcification. We aimed to quantify the association of their serum levels with incident cardiovascular disease (CVD) in the general population. Methods and Re

Externí odkaz: https://doaj.org/article/36ba538f26124108931c8425a9099b48

Shared and separate patterns in brain morphometry across transdiagnostic dimensions

Autor: Robert A. McCutcheon, Toby Pillinger, Xin Guo, Maria Rogdaki, George Welby, Luke Vano, Connor Cummings, Toni-Ann Heron, Stefan Brugger, David Davies, Mawada Ghanem, Orestis Efthimiou, Andrea Cipriani, Oliver D. Howes

Determining similarities and differences in brain structure across psychiatric disorders is important to determine if psychiatric taxonomy is reflected in distinct brain structural changes. As previous neuroimaging meta-analyses have typically focuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8bf9cbf2d7ccbcf998377dc1a53f77
https://ora.ox.ac.uk/objects/uuid:e3391e03-f3c7-46e7-b712-88e0e0b94bdc

The association between N-methyl-d-aspartate receptor availability and glutamate levels:A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls

Autor: Katherine Beck, Atheeshaan Arumuham, Stefan Brugger, Robert A McCutcheon, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Stephen Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, Teresa Sementa, Radhouene Neji, Sameer Jauhar, Franklin Aigbirhio, Istvan Boros, Federico Turkheimer, Alexander Hammers, David Lythgoe, James Stone, Oliver D Howes

Publikováno v: Beck, K, Arumuham, A, Brugger, S, McCutcheon, R A, Veronese, M, Santangelo, B, McGinnity, C J, Dunn, J, Kaar, S, Singh, N, Pillinger, T, Borgan, F, Sementa, T, Neji, R, Jauhar, S, Aigbirhio, F, Boros, I, Turkheimer, F, Hammers, A, Lythgoe, D, Stone, J & Howes, O D 2022, ' The association between N-methyl-d-aspartate receptor availability and glutamate levels : A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls ', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1051-1060 . https://doi.org/10.1177/02698811221099643

Background: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447a0ee7a2d68ead15c25c3f70e79e7
https://kclpure.kcl.ac.uk/ws/files/184987017/The_association_between_BECK_Publishedonline19September2022_GREEN_AAM.pdf

Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway

Autor: Sarah J Lewis, Claire M Perks, Richard M. Martin, Olympia Dimopoulou, Julian P.T. Higgins, Louise Mathias, Rachel James, Stefan Brugger, Claire Kelly

Publikováno v: Metabolites
Metabolites, Vol 11, Iss 726, p 726 (2021)
James, R, Dimopoulou, O, Martin, R M, Perks, C M, Kelly, C, Mathias, L, Brugger, S, Higgins, J P T & Lewis, S J 2021, ' Could Reducing Body Fatness Reduce the Risk of Aggressive Prostate Cancer via the Insulin Signalling Pathway? A Systematic Review of the Mechanistic Pathway ', Metabolites, vol. 11, no. 11, 726 . https://doi.org/10.3390/metabo11110726

Excess body weight is thought to increase the risk of aggressive prostate cancer (PCa), although the biological mechanism is currently unclear. Body fatness is positively associated with a diminished cellular response to insulin and biomarkers of ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211151ca24fe0c2d765a1a69c5246e0f
http://europepmc.org/articles/PMC8625823