Výsledky vyhledávání - "Stefan, Bentink"

Akademický článek

Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes.

Autor: Melissa A Merritt, Stefan Bentink, Matthew Schwede, Marcin P Iwanicki, John Quackenbush, Terri Woo, Elin S Agoston, Ferenc Reinhardt, Christopher P Crum, Ross S Berkowitz, Samuel C Mok, Abigail E Witt, Michelle A Jones, Bin Wang, Tan A Ince

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80314 (2013)

The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype and outcome. Here we descri

Externí odkaz: https://doaj.org/article/72352486e23d439e8ed96457071ba73e

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Akademický článek

Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis.

Autor: Matthew Schwede, Dimitrios Spentzos, Stefan Bentink, Oliver Hofmann, Benjamin Haibe-Kains, David Harrington, John Quackenbush, Aedín C Culhane

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e57799 (2013)

Although ovarian cancer is often initially chemotherapy-sensitive, the vast majority of tumors eventually relapse and patients die of increasingly aggressive disease. Cancer stem cells are believed to have properties that allow them to survive therap

Externí odkaz: https://doaj.org/article/3ab1014472544bf6b4ab08bcf4ea89cb

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Akademický článek

Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer.

Autor: Stefan Bentink, Benjamin Haibe-Kains, Thomas Risch, Jian-Bing Fan, Michelle S Hirsch, Kristina Holton, Renee Rubio, Craig April, Jing Chen, Eliza Wickham-Garcia, Joyce Liu, Aedin Culhane, Ronny Drapkin, John Quackenbush, Ursula A Matulonis

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30269 (2012)

Ovarian cancer is the fifth leading cause of cancer death for women in the U.S. and the seventh most fatal worldwide. Although ovarian cancer is notable for its initial sensitivity to platinum-based therapies, the vast majority of patients eventually

Externí odkaz: https://doaj.org/article/882777890708423181fff7a4cf12a1ab

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Akademický článek

Therapeutic implications of GIPC1 silencing in cancer.

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15581 (2010)

GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ov

Externí odkaz: https://doaj.org/article/6d1b85371e1d4a2e868189e325035379

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P130 An algorithm to detect and quantify low frequency HLA-genotypes in NGS data

Autor: Kathrin Lang, Alexander H. Schmidt, Stefan Bentink, Luca Vago, Gerhard Schöfl, Vinzenz Lange, Jürgen Sauter, Christine Gnahm, Christina Toffalori, Katharina Fleischhauer, Müberra Ahci

Aim Next-generation sequencing (NGS) provides a cost and time efficient approach for routine HLA typing. Analysis software typically presumes a diploid genotype with counts of sequencing reads from homozygous or heterozygous genotypes. However, chime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ec3b3eebe4a3a3e082112f8bf77d0c

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Abstract 2795: Dissemination score of CD8+ TILs by automated image analysis is a potential marker of immune activity in human cancers

Autor: Stefan Bentink, Andreas Spitzmueller, Tze Heng Tan, Hadassah Sade, Song Wu, Brandon W. Higgs, Keith E. Steele

Publikováno v: Cancer Research. 79:2795-2795

The overall density of CD8+ tumor-infiltrating lymphocytes (TILs) is important for characterizing the level of immune activity in the tumor microenvironment (TME). Beyond the densities of CD8+ TILs, both their location and distributional patterns may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de9f6f0fbf0a4094985a1088ae5726c
https://doi.org/10.1158/1538-7445.am2019-2795

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A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy

Autor: Stefan Bentink, Michael W. Kattan, Vince O'Neill, Mikkel Noerholm, Susan Belzer, Ian M. Thompson, Peter R. Carroll, Johan Skog, Alan W. Partin, Gerald L. Andriole, John T. Wei, James M. McKiernan, Gordon Brown, Michael J. Donovan

Publikováno v: JAMA oncology. 2(7)

Overdiagnosis and overtreatment of indolent prostate cancer (PCA) is a serious health issue in most developed countries. There is an unmet clinical need for noninvasive, easy to administer, diagnostic assays to help assess whether a prostate biopsy i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e91818f5ca1856b384070e6eb262d4
https://pubmed.ncbi.nlm.nih.gov/27032035

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SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients

Autor: Birgit Schif, Peter Möller, Ingo Melzner, Rainer Spang, Markus Kreuz, Lorenz Trümper, Olga Ritz, Markus Loeffler, Jochen K. Lennerz, Christian W. Kohler, Stefan Bentink

Publikováno v: Oncotarget

// Birgit Schif 1,* , Jochen K. Lennerz 1,* , Christian W. Kohler 2 , Stefan Bentink 2 , Markus Kreuz 3 , Ingo Melzner 1 , Olga Ritz 1 , Lorenz Trumper 4 , Markus Loeffler 3 , Rainer Spang 2 , and Peter Moller 1 1 Institute of Pathology, University o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77658159f60cfa49d07632d433154a42
http://europepmc.org/articles/PMC3702206

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