Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Stefan, Barghorn"'
Autor:
Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in Alzheimer’s disease (AD). However, the precise relationship be
Externí odkaz:
https://doaj.org/article/78bf1f0ec959455f9e1ccbfb0ccf720b
Autor:
Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/116466ed0c3c4ab5a3caa5ae928acbff
Autor:
Kerstin Schlegel, Khader Awwad, Roland G. Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R. Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparini
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unc
Externí odkaz:
https://doaj.org/article/daa0b3da5ac64eacac47f030b3004bf8
Autor:
Lise I. Loberg, Meha Chhaya, Alexander Ibraghimov, Edit Tarcsa, Andreas Striebinger, Andreas Popp, Lili Huang, Frank Oellien, Stefan Barghorn
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynom
Externí odkaz:
https://doaj.org/article/54871d30e40440c9ae5713239f79f81b
Autor:
Ameya S Kulkarni, Justin Ideozu, Aparna Vasanthakumar, Areej Ammar, Erin Murphy, Elizabeth Asque, Christian Plaas, Corinna Klein, Janina S Ried, Stefan Barghorn, Laura Gasparini
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Elena Demicheva, Yi-Fang Cui, Philip Bardwell, Stefan Barghorn, Martina Kron, Axel H. Meyer, Martin Schmidt, Björn Gerlach, Mary Leddy, Eve Barlow, Elizabeth O’Connor, Chee-Ho Choi, Lili Huang, Geertruida M. Veldman, Horea Rus, Alireza P. Shabanzadeh, Nardos G. Tassew, Philippe P. Monnier, Thomas Müller, Peter A. Calabresi, Hans Schoemaker, Bernhard K. Mueller
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1887-1898 (2015)
Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis (MS). In autopsy material from progressive MS patients, RGMa was found in active and chronic
Externí odkaz:
https://doaj.org/article/fd6bc223076f45f18b655b9a1c010a3d
Autor:
Gerald P. Gellermann, Helga Byrnes, Andreas Striebinger, Kathrin Ullrich, Reinhold Mueller, Heinz Hillen, Stefan Barghorn
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 212-220 (2008)
Soluble Aβ-oligomers are currently discussed as the major causative species for the development of Alzheimer's disease (AD). Consequently, the β-amyloid cascade hypothesis was extended by Aβ-oligomers and their central neuropathogenic role in AD.
Externí odkaz:
https://doaj.org/article/51c2a39a21a648f787f79d80a20ebc29
Autor:
Andreas Popp, Alexander Ibraghimov, Lise I. Loberg, Stefan Barghorn, Lili Huang, Meha Chhaya, Andreas Striebinger, Frank Oellien, Edit Tarcsa
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynom
Autor:
Laura Gasparini, Khader Awwad, Stefan Barghorn, Thomas R. Jahn, Annika Doell, Yulia Mordashova, Kerstin Schlegel, David Holzinger, Roland G. Heym, Michael Schulz, Corinna Klein
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if L
Autor:
Geertruida M. Veldman, Thomas Müller, Leddy Mary R, Yi Fang Cui, Hans Schoemaker, Nardos G. Tassew, Bernhard K. Mueller, Philip D. Bardwell, Horea Rus, Philippe P. Monnier, Peter A. Calabresi, Martin Schmidt, Björn Gerlach, Lili Huang, Elizabeth O'Connor, Eve H. Barlow, Elena Demicheva, Alireza P. Shabanzadeh, Axel Meyer, Chee Ho Choi, Stefan Barghorn, Martina Kron
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1887-1898 (2015)
Summary Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis (MS). In autopsy material from progressive MS patients, RGMa was found in active and