First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

Autor: Taco Metelerkamp Cappenberg, Stijn De Schepper, Christel Vangestel, Stef De Lombaerde, Leonie wyffels, Tim Van den Wyngaert, Jeffrey Mattis, Brian Gray, Koon Pak, Sigrid Stroobants, Filipe Elvas

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-15 (2023)

Abstract Background Imaging of cell death can provide an early indication of treatment response in cancer. [99mTc]Tc-Duramycin is a small-peptide SPECT tracer that recognizes both apoptotic and necrotic cells by binding to phosphatidylethanolamine pr

Externí odkaz: https://doaj.org/article/5e5aa09daddc4fbdbefd750b6971e189

Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators

Autor: Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, Vasko Kramer, Steven Staelens, Ingrid De Meester, Pieter Van der Veken, Frank Rösch

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-20 (2020)

Abstract Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibit

Externí odkaz: https://doaj.org/article/6eef6de76ec3424eabc82ef799f24e24

Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [11C]ABP688 and [18F]FPEB Positron Emission Tomography in the Sapap3 Knockout Mouse Model for Obsessive-Compulsive–like Behavior

Autor: Sigrid Stroobants, Dorien Glorie, Steven Staelens, Alan Miranda, Stef De Lombaerde, Jeroen Verhaeghe

Publikováno v: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:607-615

This study provides a first direct comparison between positron emission tomography (PET) radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [11C]ABP688 and [18F]FPEB. A blocking paradigm was set up to substa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::298fb7620dd559e6e7c6aea8b26f1bfa
https://doi.org/10.1016/j.bpsc.2021.11.010

SV2A PET Imaging Is a Noninvasive Marker for the Detection of Spinal Damage in Experimental Models of Spinal Cord Injury

Autor: Daniele Bertoglio, Nicolas Halloin, Stef De Lombaerde, Aleksandar Jankovski, Jeroen Verhaeghe, Charles Nicaise, Steven Staelens

Publikováno v: The Journal of nuclear medicine
J Nucl Med
Bertoglio, D, Halloin, N, De Lombaerde, S, Jankovski, A, Verhaeghe, J, Nicaise, C & Staelens, S 2022, ' SV2A PET imaging is a non-invasive marker for the detection of spinal damages in experimental models of spinal cord injury ', Journal of nuclear medicine, vol. 63, no. 8, pp. 1245-1251 . https://doi.org/10.2967/jnumed.121.263222
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 63, no.8, p. 1245-1251 (2022)

Traumatic spinal cord injury (SCI) is a neurological condition characterized by long-term motor and sensory neurological deficits as a consequence of an external physical impact damaging the spinal cord. Anatomical magnetic resonance imaging (MRI) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54545a2d2510697a61422c9360b3b5a
https://doi.org/10.2967/jnumed.121.263222

Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [

Autor: Dorien, Glorie, Jeroen, Verhaeghe, Alan, Miranda, Stef, De Lombaerde, Sigrid, Stroobants, Steven, Staelens

Publikováno v: Biological psychiatry. Cognitive neuroscience and neuroimaging. 7(6)

This study provides a first direct comparison between positron emission tomography radioligands targeting the allosteric site of the metabotropic glutamate receptor 5 (mGluR5): [First, wild-type mice (n = 7) received four position emission tomography

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc098a2752584524d4af9b14eac06fda
https://pubmed.ncbi.nlm.nih.gov/34856382